研究领域
Analytical/Biochemistry & Chemical Biology
Analytical Sensors, Surface Chemistry, Array Fabrication, 3D Cell Culture Systems, Molecular Recognition, Protein-DNA interactions, Synthetic Biology
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J.M. Fox, K. Kang, W. Sherman, A. Heroux, M. Sastry, M. Baghbanzadeh, M.R. Lockett, and G.M. Whitesides (2015) Interactions between Hofmeister anions and the binding pocket of a protein, accepted.
B. Mosadegh,* M.R. Lockett,* K.T. Minn, K.A. Simon, K. Gilbert, S. Hillier, D. Newsome, H. Li, A.B. Hall, D.M. Boucher, B.K. Eustace, and G.M. Whitesides (2015) A Paper-based invasion assay: Assessing the metastatic potential of cancer cells in gradients of oxygen, Biomaterials, 52 (1). 262-271.
H.J. Yoon, K.C. Liao, M.R. Lockett, S.W. Kwok, M. Baghbanzadeh, and G.M. Whitesides (2014) Rectification in tunneling junctions: 2,2'-bipyridyl-terminated n-alkanethiolates, J. Am. Chem. Soc., 136 (49). 17155-17162.
B. Mosadegh, B.E. Dabiri, M.R. Lockett, R. Derda, P. Campbell, K.K. Parker, and G.M. Whitesides (2014) Three-dimensional paper-based model for cardiac ischemia, Adv. Healthcare Mat., 3. 1036-1043.
P.W. Snyder,* M.R. Lockett,* D.T. Moustakas, and G.M. Whitesides (2014) Is it the shape of the pocket, or the shape of water within the pocket?, Eur. J. Phys. Spec. Top., 223 (5). 853-891.
B. Breiten,* M.R. Lockett,* W. Sherman, M. Al-Sayah, S. Fujita, H. Lange, C.M. Bowers, A. Heroux, G. Krilov, and G.M. Whitesides (2013) Water networks contribute to enthalpy/entropy compensation in protein-ligand binding, J. Am. Chem. Soc., 135 (41). 15579–15584.
R. Derda,* M.R. Lockett,* S.K.Y. Tang, R.C. Fuller, E.J. Maxwell, B. Breiten, C.A. Cuddemi, A. Ozdogan, and G.M. Whitesides (2013) Filter-based assay for E. coli in aqueous samples using bacteriophage-based amplification. Anal. Chem., 85 (15). 7213-7220.
M.R. Lockett,* H. Lange,* B. Breiten,* A. Heroux, W. Sherman, D. Rappoport, P.O. Yau, P.W. Snyder, and G.M. Whitesides (2013) The binding of benzoarylsulfonamide ligands to human carbonic anhydrase is insensitive to formal fluorination of the ligand, Angew. Chem., Int. Ed., 52 (30). 7714-7717.
M.R. Lockett, K.M. Mirica, C.R. Mace, R. Blackledge, and G.M. Whitesides (2013) Analysis of forensic evidence based on density with magnetic levitation, J. Forens. Sci., 58 (1). 40-45.
A.H. Broderick, M.C.D. Carter, M.R. Lockett, L.M. Smith, and D.M. Lynn (2013) Fabrication of oligonucleotide and protein arrays on rigid and flexible surfaces coated with reactive polymer multilayers, ACS Appl. Mater. Interfaces, 5 (2). 351-359.
K.A. Mirica, M.R. Lockett, P.W. Snyder, N.D. Shapiro, and G.M. Whitesides (2012) Selective precipitation and purification of monovalent proteins using oligovalent ligands and ammonium sulfate, Bioconj. Chem., 23 (2). 293-299.
C.H. Wu, M.R. Lockett, L.M. Smith (2012) RNA gene assembly from DNA arrays, Angew. Chem., Int. Ed., 51 (19). 4628-4632.
A.H. Broderick,* M.R. Lockett,* M.E. Buck, Y. Yuan, L.M. Smith, and D.M. Lynn (2012) Layer-by-layer assembled films for the in-situ synthesis of oligonucleotide arrays, Chem. Mater., 24 (5). 938-945.
P.W. Snyder, J. Mecinovic, D.T. Moustakas, S.W. Thomas, M. Harder, E.T. Mack, M.R. Lockett, A. Heroux, W. Sherman, and G.M. Whitesides (2011) The origin of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase, Proc. Natl. Acad. Sci.U.S.A., 108 (44). 17889-17894.
C.N. Olson, M.M. Galloway, G. Yu, C.J. Hedman, M.R. Lockett, T.P. Yoon, E.A. Stone, L.M. Smith,C.N. Olson, M.M. Galloway, G. Yu, C.J. Hedman, M.R. Lockett, T.P. Yoon, E.A. Stone, L.M. Smith, and F.N. Keutsch (2011) Hydroxycarboxylic acid-derived organosulfates: synthesis, stability and quantification in ambient aerosol, Environ. Sci. Technol., 45 (15). 6468-6474.
M.R. Lockett and L.M. Smith (2010) Halogenation of carbon substrates for increased reactivity with alkenes, Langmuir, 26 (22). 16642-16646.
M.R. Lockett and L.M. Smith (2010) The formation and stability of alkyl thiol monolayers on carbon substrates, J. Phys. Chem. C, 114 (29). 12635-12641.
J.B. Mandir,* M.R. Lockett,* M.F. Phillips, H.T. Allawi, V.I. Lyamichev, and L.M. Smith (2009) Rapid Detection of RNA accessible sites by surface plasmon resonance detection of hybridization to DNA arrays, Anal. Chem., 81 (21). 8949-8956.
M.R. Lockett and L.M. Smith (2009) Fabrication and Characterization of DNA Arrays Prepared on Carbon-on-Metal Substrates, Anal. Chem., 81 (15). 6429-64037.
M.R. Lockett, D.V. Le, J.C. Carlisle, and L.M. Smith (2009) Acyl chloride-modified amorphous carbon substrates for the attachment of alcohol-, thiol-, and amine-containing molecules, Langmuir, 25 (9). 5120-5126.
M.R. Lockett and L.M. Smith (2009) Attaching molecules to chlorinated and brominated amorphous carbon substrates via Grignard reactions, Langmuir, 29 (6). 3340-3343.
M.R. Lockett, M.R. Shortreed, and L.M. Smith (2008) Aldehyde terminated amorphous carbon surfaces for the fabrication of biomolecule arrays, Langmuir, 24 (17). 9198-9203.