个人简介

Dr. Hicks received her B.S. in Chemistry at Marshall University (summa cum laude) and Ph.D. in Analytical Chemistry at the University of Illinois, Urbana-Champaign where she was the recipient of an NSF Graduate Research Fellowship. She was an Assistant Member and Principal Investigator at the Donald Danforth Plant Science Center and an adjunct professor in the Department of Biology at Washington University in St. Louis prior to assuming her current role as an assistant professor in the Department of Chemistry at UNC.

研究领域

Analytical/Biochemistry & Chemical Biology

Research in the Hicks lab focuses on development and implementation of mass spectrometric approaches for protein characterization including post-translational modifications, as well as the identification of bioactive peptides/proteins from plants.

近期论文

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W. O. Slade, E. G. Werth, E. W. McConnell, S. Alvarez, L. M. Hicks, Quantifying Reversible Oxidation of Protein Thiols in Photosynthetic Organisms. J Am Soc Mass Spectrom, 2015. [Epub] Wang, H., B. Gau, W.O. Slade, M. Jeurgens, P. Li, L.M. Hicks, The global phosphoproteome of Chlamydomonas reinhardtii reveals complex organellar phosphorylation in the flagella and thylakoid membrane. Mol Cell Proteomics, 2014. 13(9): 2337-53. Slade, W.O., E.G. Werth, A. Chao, L.M. Hicks, Phosphoproteomics in photosynthetic organisms. Electrophoresis, 2014. 35(24): 3441-51. Deng, X., E. Weerapana, O. Ulanovskaya, F. Sun, H. Liang, Q. Ji, Y. Ye, Y. Fu, L. Zhou, J. Li, H. Zhang, C. Wang, S. Alvarez, L.M. Hicks, L. Lan, M. Wu, B.F. Cravatt, and C. He, Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria. Cell Host Microbe, 2013. 13(3): 358-70. Alvarez, S., S. Roy Choudhury, L.M. Hicks, and S. Pandey, Quantitative proteomics-based analysis supports a significant role of GTG proteins in regulation of ABA response in Arabidopsis roots. J Proteome Res, 2013. 12(3): 1487-501. Zhang, M., G.E. Ravilious, L.M. Hicks, J.M. Jez, and R.D. McCulla, Redox switching of adenosine-5′-phosphosulfate kinase with photoactivatable atomic oxygen precursors. J Am Chem Soc, 2012. 134(41): 16979-82. Wang, H., S. Wang, Y. Lu, S. Alvarez, L.M. Hicks, X. Ge, and Y. Xia, Proteomic analysis of early-responsive redox-sensitive proteins in Arabidopsis. J Proteome Res, 2012. 11(1): 412-24. Wang, H., S. Alvarez, and L.M. Hicks, Comprehensive comparison of iTRAQ and label-free LC-based quantitative proteomics approaches using two Chlamydomonas reinhardtii strains of interest for biofuels engineering. J Proteome Res, 2012. 11(1): 487-501. Sun, F., H. Liang, X. Kong, S. Xie, H. Cho, X. Deng, Q. Ji, H. Zhang, S. Alvarez, L.M. Hicks, T. Bae, C. Luo, H. Jiang, and C. He, Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA. Proc Natl Acad Sci U S A, 2012. 109(23): 9095-100. Sun, F., Y. Ding, Q. Ji, Z. Liang, X. Deng, C.C. Wong, C. Yi, L. Zhang, S. Xie, S. Alvarez, L.M. Hicks, C. Luo, H. Jiang, L. Lan, and C. He, Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance. Proc Natl Acad Sci U S A, 2012. 109(38): 15461-6. Galant, A., R.P. Koester, E.A. Ainsworth, L.M. Hicks, and J.M. Jez, From climate change to molecular response: redox proteomics of ozone-induced responses in soybean. New Phytol, 2012. 194(1): 220-9. Zhang, Y., B. Zhang, D. Yan, W. Dong, W. Yang, Q. Li, L. Zeng, J. Wang, L. Wang, L.M. Hicks, and Z. He, Two Arabidopsis cytochrome P450 monooxygenases, CYP714A1 and CYP714A2, function redundantly in plant development through gibberellin deactivation. Plant J, 2011. 67(2): 342-53. Zhang, B., K.M. Watts, D. Hodge, L.M. Kemp, D.A. Hunstad, L.M. Hicks, and A.R. Odom, A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. Biochemistry, 2011. 50(17): 3570-7. Song, C.X., K.E. Szulwach, Y. Fu, Q. Dai, C. Yi, X. Li, Y. Li, C.H. Chen, W. Zhang, X. Jian, J. Wang, L. Zhang, T.J. Looney, B. Zhang, L.A. Godley, L.M. Hicks, B.T. Lahn, P. Jin, and C. He, Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol, 2011. 29(1): 68-72. Chen, H., B. Zhang, L.M. Hicks, and L. Xiong, A nucleotide metabolite controls stress-responsive gene expression and plant development. PLoS One, 2011. 6(10): e26661. Alvarez, S., L.M. Hicks, and S. Pandey, ABA-dependent and -independent G-protein signaling in Arabidopsis roots revealed through an iTRAQ proteomics approach. J Proteome Res, 2011. 10(7): 3107-22. Alvarez, S. and L.M. Hicks, Survey in plant root proteomics: to know the unknown, in Sustainable Agriculture and New Biotechnologies, N. Benkeblia, Editor. 2011, CRC Press: Boca Raton, FL. p. 215-256. Alvarez, S., A. Galant, J.M. Jez, and L.M. Hicks, Redox-regulatory mechanisms induced by oxidative stress in Brassica juncea roots monitored by 2-DE proteomics. Proteomics, 2011. 11(7): 1346-50. Zhang, B., V. Tolstikov, C. Turnbull, L.M. Hicks, and O. Fiehn, Divergent metabolome and proteome suggest functional independence of dual phloem transport systems in cucurbits. Proc Natl Acad Sci U S A, 2010. 107(30): 13532-7. Wu, B., B. Zhang, X. Feng, J.R. Rubens, R. Huang, L.M. Hicks, H.B. Pakrasi, and Y.J. Tang, Alternative isoleucine synthesis pathway in cyanobacterial species. Microbiology, 2010. 156(Pt 2): 596-602.