杨震 - 北京大学 - 化学生物学与生物技术学院

个人简介

EDUCATION B.S. in Medicinal Chemistry The Chinese University of Hong Kong (1989-1992) Shenyang College of Pharmacy, P. R. China (1983-1986) Shenyang College of Pharmacy, P. R. China (1978-1982) EXPERIENCE 2006.1-present Dean of School of Chemical Biology and Biotechnology, PKUSZ 2003.1-present Director of Key Laboratory of Chemical Genomics, PKUSZ 2001.9-present Changjiang Professor College of Chemistry, Peking University, Beijing, China Research Interest:Total Synthesis of Natural Product and Organometallic Chemistry Diversity Oriented Synthesis and Chemical Biology 2005.9-present Director of Chemistry XTL Biophamaceutical, New York, USA Research Interest:Medicinal Chemistry and Combinatorial Chemistry 2001.5-2005.9 Co-Founder and Director of Chemistry VivoQuest. Inc. New York, USA Research Interest:Anti-Viral Drug Discovery 1998.5-2001.5 Institute fellow Harvard Institute of Chemistry and Cell Biology,Harvard University Research Interest:Diversity Oriented Synthesis 1995.6-1998.5 Assistant Professor The Scripps Research Institute Research Interest: Total Synthesis of Complex Natural Products 1992.5-1995.5 Postdoctoral Fellow The Scripps Research Institute Topic: Total Syntheses of Taxol, Brevetoxin A and Epothilone A

研究领域

Natural product exists in an infinite range of complexity and diversity, and often presents dazzling biological activities. The total synthesis of complex natural product s involves distinct synthetic problems which require not only ingenuity and skills, but also the unique strategies and tactics for their solution. The research program in our group aimed for the development of novel synthetic methodologies and strategies, then applied them to the syntheses of complex natural products, which is highly attractive, valuable, and rewarding in both chemical embodiments and medicinal demand. To those who enjoy challenges and aspire the awesome power of creating new molecules; And to those who also treasure the tremendous medicinal potencial of natural product-likes compounds, our approach provides potent chemical tools and physiological insight may be invaluable for the treatment of diseases and utilized as probes to regulate the importantly biological targets.

近期论文

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Hao-Yuan Liu, Zhen-Yu Zhang, Yi-Ke Zhou, Jia-Hua Chen, Zhen Yang,* and Yuan-He Li*Chem Asian J.2023,18, e20230062 Shu-Min Lu, Chao Chen, Chang Liu, Rudong Liu, Jia-Hua Chen,* Zhongchao Zhang,* and Zhen Yang*Org. Lett. 2023, 25(13), 2264–2269 Yuan-He Li, Su-Lei Zhang, Yong Lu, Bo Xiao, Tian-Yu Sun, Qian-Qian Xu, Jia-Hua Chen,* Zhen Yang*Angew. Chem. Int. Ed. 2023, e202303075 Zhiming Yan, Chunbo Zhao, Zhen Yang*, Jianxian Gong*Tetrahedron Letters 2023, 117 (2023), 154361-154363 Zhongchao Zhang, Zhen Yang *SCIENTIA SINICA Chimica 2023, 53(3), 277-288 Hai-Xin Yu, Nan Zheng, Chi-Tai Yeh, Chien-Ming Lee, Qi Zhang, Wen-Lv Zheng, Qing Chang, Yuan-He Li, Yu-Jun Li, Gui-Zhen Wu∗, Jun-Min Quan∗, Lin-Qi Zhang∗, Yew-Min Tzeng∗ and Zhen Yang∗National Science Review 2022, 9(11), nwac 176 Anding Li, Nan Zheng, Kai Guo, Zhongchao Zhang and Zhen Yang*Catalysts 2022, 12(3), 333 Jun Huang,* Tingting Cao, Zhongchao Zhang, and Zhen Yang*J. Am. Chem. Soc. 2022, 144,(6), 2479–2483 Tingting Cao, Lei Zhu,* Jun Huang,* and Zhen Yang*Org. Lett. 2022, 24,(7), 1491–1495 Lijie Zhang, Rongya Wang, Chao Wang, Bingyan Liu, Jinfeng Yang, Zhongchao Zhang, Jun Huang,*and Zhen Yang*Org. Lett. 2022, 24(21), 3786–3791 Jiangqun Cheng, Yuan-He Li, Jun Huang,* and Zhen Yang*Org. Lett. 2021, 23(21), 8465–8470 Zhongchao Zhang, Sijia Chen, Fu Tang, Kai Guo, Xin-Ting Liang, Jun Huang,* and Zhen Yang*J. Am. Chem. Soc. 2021, 143,(43), 18287–18293 Xiao Wang, Dian Li, Junlin Zhang, Jianxian Gong, Junkai Fu,* and Zhen Yang*Org. Lett. 2021, 23,(13), 5092–5097 Anding Li, Ziru He, Bingyan Liu, Zhen Yang*, and Zichun Zhang*Org. Lett. 2021, 23,(23), 9237–9240 Qian Tu, Zheyuan Wang, Zhongchao Zhang, Jun Huang*, and Zhen Yang*Org. Lett. 2021, 23(11), 4088–4093 Sijia Chen, Zhongchao Zhang, Chongguo Jiang, Chunbo Zhao, Haojie Luo, Jun Huang*, and Zhen Yang*ACS Omega 2021, 6(29), 18848–18859 Dian Li, Jinfeng Yang, Bingyan Liu, Jianxian Gong,* and Zhen Yang*Org. Lett. 2021, 23(12), 4532–4537 Xin-Peng Mu, Yuan-He Li, Nan Zheng, Jian-Yu Long, Si-Jia Chen, Bing-Yan Liu, Chun-Bo Zhao, and Zhen Yang*Angew.Chem. Int. Ed. 2021, 60(20), 11211-11216 Zhen Yang*Acc. Chem. Res. 2021, 54(3), 556–568 Xin-Ting Liang, Bao-Chuan Sun, Nan Zhang, Zhong-Chao Zhang, Yuan-He Li, Qian-Qian Xu, Chang Liu, Jia-Hua Chen,* and Zhen Yang*J. Org. Chem. 2021, 86(3), 2158–2172 Xin-Ting Liang, Bao-Chuan Sun, Chang Liu, Yuan-He Li, Nan Zhang, Qian-Qian Xu, Zhong-Chao Zhang, Yi-Xin Han, Jia-Hua Chen,* and Zhen Yang*J. Org. Chem. 2021, 86(3), 2135–2157 Jiang, Chongguo†, Chen, Sijia†, Gong, Jianxian*, Yang, Zhen*Acta Chim. Sinica 2020, 78(9), 928—932 Wei Zhang, Zhenyu Zhang, Jun-Chen Tang, Jin-Teng Che, Hao-Yu Zhang, Jia-Hua Chen,* and Zhen Yang*J. Am. Chem. Soc. 2020, 142(46), 19487–19492 Sijia Chen†, Chongguo Jiang†, Nan Zheng, Zhen Yang* and Lili Shi*Catalysts, 2020, 10 (10), 1199 Zi-Chun Zhang†, Dan-Dan Zhao†, Zhong-Chao Zhang, Xin-Yu Tan, Jian-Xian Gong*, Jun-Kai Fu* & Zhen Yang*Chinese Chemical Society, 2020, 2(5), 2074–2083 Xin-Ting Liang, Jia-Hua Chen,* and Zhen Yang*J. Am. Chem. Soc. 2020, 142(18), 8116–8121 Kai Guo, Zhongchao Zhang, Anding Li, Yuanhe Li, Jun Huang,* Zhen Yang,*Angew. Chem. Int. Ed.2020, 59(28), 11660-11668 Yongzheng Qu, Zheyuan Wang, Zhongchao Zhang, Wendou Zhang, Jun Huang,* and Zhen Yang*J. Am. Chem. Soc. 2020, 142(14), 6511-6515 Zhiming Yan, Chunbo Zhao, Jianxian Gong,* and Zhen Yang*Org. Lett. 2020, 22(4), 1644-1647 Tingting Cao, Lei Zhu, Yu Lan*, Jun Huang* and Zhen Yang*Org. Lett. 2020, 22(7), 2517-2521 Song Liu, Tao Zhang, Lei Zhu, Kangbao Zhong, Jianxian Gong, Zhen Yang*, Ruopeng Bai*, Yu Lan*Chem. Commun., 2018,54(96), 13551-13554 Linlin Shi, Yingdong He, Jianxian Gong *, Zhen Yang *Chem. Commun. 2020,56(4), 531-534 Yan-Long Jiang, Hai-Xin Yu, Yong Li, Pei Qu, Yi-Xin Han, Jia-Hua Chen*, Zhen Yang*J. Am. Chem. Soc.2020, 142(1), 573-580 Pengpeng Zhang, Yuanhe Li, Zhiming Yan, Jianxian Gong*, Zhen Yang*J. Org. Chem. 2019, 84(24), 15958-15971 Wei Chen, Renyu Guo, Jianxian Gong*, Zhen Yang*Chin. J. Org. Chem. 2019, 39 (1), 238-248 Rong Long, Zhen Yang*Tetrahedron 2019, 75 (12), 1746-1750 Linlin Shi, Yingdong He, Jianxian Gong*, Zhen Yang*Asian J. Org. Chem 2019, 8 (6), 823-827