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个人简介

医学博士,教授,博士生导师,国家杰出青年基金获得者,教育部讲座教授特聘教授,北京大学博雅特聘教授,中国脑计划重大项目首席科学家,北京大学中国药物依赖性研究所常务副所长。 担任药物依赖性研究北京市重点实验室主任、中国毒理学会药物依赖性专业委员会主任委员、国家禁毒委中国毒品滥用防治专家委员会副主任委员兼秘书长、中国睡眠研究会副理事长、海峡两岸医药卫生交流协会睡眠医学专业委员会副主任委员兼秘书长等。 长期从事药物成瘾及睡眠障碍等相关疾病的神经机制和干预策略研究,在Science、JAMA Psychiatry、Am J Psychiatry、Brain Behav Immun、Sci Adv、Mol Psychiatry及Biol Psychiatry等SCI期刊发表论文240余篇,作为负责人主持国家自然科学基金委、科技部、军委科技委、脑科学与类脑研究北方科学中心以及世界卫生组织等30余项科研项目,多次获得教育部优秀成果自然科学奖一等奖、中华医学科技奖一等奖和二等奖、吴阶平-保罗·杨森医学药学奖等学术奖励。

研究领域

长期从事药物成瘾及睡眠障碍、抑郁症等相关精神疾病的神经机制和干预策略研究。主要研究方向包括: 1)成瘾的神经和遗传影像学机制及干预; 2)睡眠-觉醒的脑功能调控及其机制研究; 3)抑郁症的发病机制及干预。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Zheng JW#, Ai SZ#, Chang SH, Meng SQ, Shi L, Deng JH, Di TQ, Liu WY, Chang XW, Yue JL, Yang XQ, Zeng N, Bao YP, Sun Y*, Lu L*, Shi J*. Association between alcohol consumption and sleep traits: observational and mendelian randomization studies in the UK biobank. Mol Psychiatry. 2024, 29(3):838-846. 2. Chen W#, Zhang Y#, Liang J#, Zhang Z, Zhang L, Huang E, Zhang G, Lu L*, Han Y*, Shi J*. Disrupting astrocyte-neuron lactate transport prevents cocaine seeking after prolonged withdrawal. Sci Adv. 2023, 9(43):eadi4462. 3. Yu Z, Chen W, Zhang L, Chen Y, Chen W, Meng S, Lu L, Han Y*, Shi J*. Gut-derived bacterial LPS attenuates incubation of methamphetamine craving via modulating microglia. Brain Behav Immun. 2023, 111:101-115. 4. Chen Y#, Wang G#, Zhang W, Han Y, Zhang L, Xu H, Meng S, Lu L*, Xue Y*, Shi J*. An orbitofrontal cortex-anterior insular cortex circuit gates compulsive cocaine use. Sci Adv. 2022, 8(51):eabq5745. 5. Yu Z#, Han Y#, Hu D#, Chen N, Zhang Z, Chen W, Xue Y, Meng S, Lu L, Zhang W*, Shi J*. Neurocan regulates vulnerability to stress and the anti-depressant effect of ketamine in adolescent rats. Mol Psychiatry. 2022, 27(5):2522-2532. 6. Meng SQ, Cheng JL, Li YY, Yang XQ, Zheng JW, Chang XW, Shi Y, Chen Y, Lu L, Sun Y*, Bao YP*, Shi J*. Global prevalence of digital addiction in general population: A systematic review and meta-analysis. Clin Psychol Rev. 2022, 92:102128. 7. Sun Y#, Chang S#, Liu Z, Zhang L, Wang F, Yue W, Sun H, Ni Z, Chang X, Zhang Y, Chen Y, Liu J, Lu L, Shi J*. Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence. Mol Psychiatry. 2021, 26(4):1152-1161. 8. Han Y#, Sun CY#, Meng SQ#, Tabarak S, Yuan K, Cao L, Yan W, Xu LZ, Deng JH, Zhu WL, Li JL, Lu L*, Xue YX*, Shi J*. Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects. Mol Psychiatry. 2020, 25(6):1260-1274. 9. Ma J, Bao YP*, Wang RJ, Su MF, Liu MX, Li JQ, Degenhardt L, Farrell M, Blow FC, Ilgen M, Shi J*, Lu L*. Effects of medication-assisted treatment on mortality among opioids users: a systematic review and meta-analysis. Mol Psychiatry. 2019, 24(12):1868-1883. 10. Ai SZ#, Yin YL#, Chen Y, Wang C, Sun Y, Tang XD, Zhu LS*, Shi J*. Promoting subjective preferences in simple economic choices during nap. eLife. 2018, 7: e40583. 11. Chen J, Liang J, Lin X, Zhang Y, Zhang Y, Lin L, Shi J*. Sleep deprivation promotes habitual control over goal-directed control: behavioral and neuroimaging evidence. J Neurosci. 2017, 37(49):11979-11992. 12. Liang J#, Li JL#, Han Y#, Luo YX, Xue YX, Zhang Y, Zhang Y, Zhang LB, Chen ML, Lu L, Shi J*. Calpain-GRIP Signaling in Nucleus Accumbens Core Mediates the Reconsolidation of Drug Reward Memory. J Neurosci. 2017, 37(37):8938-8951 13. Zhang Y#, Xue Y#, Meng S, Luo Y, Liang J, Li J, Ai S, Sun C, Shen H, Zhu W, Wu P, Lu L, Shi J*. Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse. Biol Psychiatry. 2016, 79(11): 928-39. 14. Xue YX#, Luo YX#, Wu P, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Bao YP, Shi J, Epstein DH, Shaham Y, Lu L*. A memory retrieval-extinction procedure to prevent drug craving and relapse. Science. 2012, 336(6078):241-245. 15. Zhang XL, Shi J*, Zhao LY, Sun LL, Wang J, Wang GB, Epstein DH, Lu L*. Effects of stress on decision-making deficits in formerly heroin-dependent patients after different durations of abstinence. Am J Psychiatry. 2011, 168(6):610-616.

学术兼职

药物依赖性研究北京市重点实验室主任 中国毒理学会药物依赖性专业委员会主任委员 国家禁毒委中国毒品滥用防治专家委员会副主任委员兼秘书长 中国睡眠研究会副理事长 海峡两岸医药卫生交流协会睡眠医学专业委员会副主任委员兼秘书长

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