杨吉春 - 北京大学 - 基础医学院

个人简介

1993.9-1997.7 北京大学生命科学学院生化分子生物学专业本科 1997.9-2002.7 北京大学生命科学学院生化分子生物学专业博士 2003.4-2006.5 美国宾夕法尼亚大学医学院博士后 2006.6-2014.6 北京大学医学部基础医学院生理学与病理生理学系副教授 2014.6-现今北京大学医学部基础医学院生理学与病理生理学系教授

研究领域

2型糖尿病及其血管病变发生机制；研究方向：胰岛β细胞功能障碍及肝脏糖脂代谢异常在2型糖尿病发生发展过程中的作用；糖尿病血管病变。

近期论文

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1.Wang J, Ma R, Ma W, Chen J, Yang J*, Xi Y*, Cui Q*. LncDisease: a sequence based bioinformatics tool for predicting lncRNA-disease associations. Nucleic Acids Res . 2016 Feb 16. pii: gkw093. [Epub ahead of print] 2.Cai J, Shi X, Wang H, Fan J, Feng Y, Lin X, Yang J, Cui Q, Tang C, Xu G, Geng B.Cystathionine γ lyase-hydrogen sulfide increases peroxisome proliferator-activated receptor γ activity by sulfhydration at C139 site thereby promoting glucose uptake and lipid storage in adipocytes. Biochim Biophys Acta . 2016 Mar 2. [Epub ahead of print] 3.Liao F, Zheng Y, Cai J, Fan J, Wang J, Yang J, Cui Q, Xu G, Tang C, Geng B. Catestatin attenuates endoplasmic reticulum induced cell apoptosis by activation type 2 muscarinic acetylcholine receptor in cardiac ischemia/reperfusion. Sci Rep . 2015 Nov 16;5:16590. doi: 10.1038/srep16590. 4.Chen Z, Luo Y, Yang W, Ding L, Wang J, Geng B, Cui Q* and Yang J*. Comparison analysis of dysregulated LncRNA profile in plasma and liver of mice after hepatic ischemia/reperfusion injury. PloS One 2015 Jul 29;10(7):e0133462. 5.Zhang X, Liu J, Yang J* and Guan Y*. FAM3A and FAM3B (PANDER) are a pair of Yin-Yang regulators in hepatic lipid and glucose metabolism. J Molcular Cellular Biolology 2016 （invited review，accepted) 6.Wang C, Chen Z, Li S, Zhang Y, Jia S, Li J, Chi Y, Miao Y, Guan Y, Yang J*. Hepatic overexpression of ATP synthase β subunit activates PI3K/Akt pathway to ameliorate hyperglycemia of diabetic mice. Diabetes. 2014, 63:947-59 . 7.Wang C, Chi Y, Li J, Miao Y, Li S, Su W, Jia S, Chen Z, Du S, Zhang X, Zhou Y, Wu W, Zhu M, Wang Z, Yang H, Xu G, Wang S, Yang J*, and Guan Y*.FAM3A activates p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis. Hepatology. 2014, 59:1779-1790. 8.Jia S, Chen Z, Li J, Chi Y, Wang J, Li S, Luo Y, Geng B, Wang C, Cui Q, Guan Y and Yang J*. FAM3A promotes vascular smooth muscle cell proliferation and migration and exacerbates neointima formation in rat artery after balloon injury J Mol Cell Cardiol . 2014, 74:173-182. 9.Ma W, Zhang L, Zeng P, Huang C, Li J, Geng B, Yang J, Kong W, Zhou X, Cui Q. An analysis of human microbe-disease associations. Brief Bioinform . 2016 Feb 15. pii: bbw005. [Epub ahead of print] 10.Liao F, Zheng Y, Cai J, Fan J, Wang J, Yang J, Cui Q, Xu G, Tang C, Geng B. Catestatin attenuates endoplasmic reticulum induced cell apoptosis by activation type 2 muscarinic acetylcholine receptor in cardiac ischemia/reperfusion. Sci Rep . 2015 Nov 16;5:16590. doi: 10.1038/srep16590. 11.Liu Y, Yang J and Chen L. Structure and function of SLC4 family HCO3– transporters. Front Physiol . 2015 Dec 1;6:355. eCollection 2015. 12.Wang DK, Liu Y, Myers EJ, Guo YM, Xie ZD, Jiang DZ, Li JM, Yang J, Liu M, Parker MD, Chen LM. Effects of Nt-truncation and coexpressing isolated Nt domain on membrane trafficking of electroneutral Na+/HCO3- cotransporters. Sci Rep . 2015 Jul 20;5:12241. doi: 10.1038/srep12241.. 13.Li J, Ma W, Zeng P, Wang J, Geng B, Yang J, Cui Q. LncTar: a tool for predicting the RNA targets of lncRNAs. Brief Bioinform .2015, Sep;16(5):806-12. 14.Wang C, Geng B, Cui Q, Guan Y and Yang J*. Intracellular and extracellular adenosine triphosphate in regulation of insulin secretion in pancreatic beta cells J Diabetes . 2014, 6:113-119. 15.Wei B, Cai L, Sun D, Wang Y, Wang C, Chai X, Xie F, Su M, Ding F, Liu J, Yang J, Guan Y and Liu X. Microsomal Prostaglandin E Synthase-1 Deficiency Exacerbates Idiopathic Pulmonary Fibrosis Induced by Bleomycin in Mice. Molecules. 2014, 19:4967-85. 16.Li Y, Qiu C, Tu J, Geng B, Yang J, Jiang T and Cui Q. HMDD v2.0: a database for experimentally supported human microRNA and disease associations. Nucleic Acids Research. 2014, 42:D1070-4 17.Zhou Y, Jia S, Wang C, Chen Z, Chi Y, Li J, Xu G, Guan Y and Yang J*. FAM3A is a target gene of peroxisome proliferator activated receptor-gamma. Biochim Biophys Acta . 2013,1830: 4160-4170. 18.Chen Z, Jia S, Li D, Tu J, Geng B, Guan Y, Cui Q and Yang J*. Silencing of long noncoding RNA AK139328 attenuates ischemia-reperfusion injury in mouse livers. 2013 PloS One . November 2013, 8(11): e80817. 19.Yang J and Guan Y. Family with sequence similarity 3 and non-alcoholic fatty liver diseases. J Gastroen Hepatol 2013, S1:105-11. 20.Yang J,Kang J and Guan Y. The mechanisms linking adiposopathy to type 2 diabetes. Front Med. 2013,7(4):433-44.