邵根泽 - 北京大学 - 基础医学院

个人简介

教育经历 2000－2003：北京大学基础医学院细胞生物学专业，博士 1993－1996：汕头大学医学院肿瘤生物化学专业，硕士 1986－1990：华东师范大学生物系，本科工作经历 2010－现在：北京大学基础医学院细胞生物学系教授 2006－2010：美国宾西法尼亚大学医学院博士后 2004－2006：美国哥伦比亚大学放射研究中心博士后 1996－2000：汕头大学医学院生物化学助教、讲师 1990－1993：江西省吉安师范专科学校生物学助教

研究领域

细胞内许多关键蛋白质分子（尤其是抑癌基因产物）在维护基因组的完整性中发挥重要作用；一旦功能改变或失活，可以导致基因突变、染色体异常等多种基因组不稳定性现象，促进细胞转化和癌变。因此研究细胞稳态调控的机制对于阐明肿瘤发生和转移的机制具有重要意义。本研究室主要研究细胞内肿瘤相关的关键蛋白质分子功能及其在维护基因组稳定性方面的作用。

近期论文

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1. Kuang J, Li L*, Guo L, Su Y, Wang Y, Xu Y, Wang X, Meng S, Lei L, Xu L, Shao G*. RNF8 promotes epithelial-mesenchymal transition of breast cancer cells. J Exp Clin Cancer Res. 2016 Jun 4;35(1):88 2. Yan K, Li L*, Wang X, Hong R, Zhang Y, Yang H, Lin M, Zhang S, He Q, Zheng D, Tang J, Yin Y, Shao G*. The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells. J Cell Biol. 2015; 210:209-224. doi:10.1083/jcb.201503039 （cover story） 3. Yi J, Lu G, Li L, Wang X, Cao L, Lin M, Zhang S, Shao G*. DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation. Nucleic Acids Res. 2015 May 19; 43(9):4579-90 doi: 10.1093/nar/gkv325 4. Zhu B, Yan K, Li L, Lin M, Zhang S, He Q, Zheng D, Yang H*, Shao G*. K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks. Oncogene. 2015 May 28;34(22):2867-78. doi: 10.1038/onc.2014.229. Epub 2014 Aug 18. 5. Wang X, Lu G, Li L, Yi J, Yan K, Wang Y, Zhu B, Kuang J, Lin M, Zhang S, Shao G*. HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway. Biochem Biophys Res Commun. 2014; 444(4):549-54. 6. Patterson-Fortin J, Shao G, Bretscher H, Messick TE, Greenberg RA. Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex. J Biol Chem. 2010；285(40):30971-81 7. Shao G, Patterson-Fortin J, Messick TE, Feng D, Shanbhag N, Wang Y, Greenberg RA. Merit 40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double strand breaks. Genes & Development. 2009; 23(6):740-54 8. Shao G, Lilli DR, Patterson-Fortin J, Coleman KA, Morrissey DE, Greenberg RA. The Rap80-BRCC36 Deubiquitinating Complex Antagonizes RNF8-Ubc13 Dependent Ubiquitination Events at DNA Double Strand Breaks. Proc Natl Acad Sci U S A. 2009; 106(9): 3166-71 9. Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau LA, Xia B, Livingston DM, Greenberg RA.Rap80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science. 2007; 316(5828): 1198-202 10. Shao G, Berenguer J, Borczuk AC, Powell CA, Hei TK, Zhao Y. Epigenetic inactivation of Betaig-h3 gene in human cancer cells. Cancer Res. 2006; 66(9): 4566-4573 11. Zhang Y, Wen G, Shao G, Wang C, Lin C, Fang H, Balajee AS, Bhagat G, Hei TK, Zhao Y. TGFBIDeficiency Predisposes Mice to Spontaneous Tumor Development. Cancer Res. 2009; 69 37-44. 12. Shao G, Balajee AS, Hei TK, Zhao Y. p16INK4a downregulation is involved in immortalization of primary human prostate epithelial cells induced by telomerase. Mol Carcinog. 2008; 47(10): 775-83 13. Shah JN, Shao G, Hei TK, Zhao Y. Methylation screening of the TGFBI promoter in human lung and prostate cancer by methylation-specific PCR. BMC Cancer. 2008; 8:284 14. Shao GZ, Zhou RL, Zhang QY, Zhang Y, Liu JJ, Rui JA, Wei X, Ye DX. Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. Oncogene2003, 22: 5060-9