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个人简介

受教育经历 2001年-2007年,中科院昆明动物研究所,博士 2006年-2008年 ,德国柏林野生与笼养动物研究所,访问学者 1995年-1999年,云南师范大学,生命科学系,本科 工作经历 2014年12月-,昆明理工大学生命科学与技术学院,教授 2011年7月-,云南省灵长类生物医学重点实验室,生物医学动物模型国家地方联合工程研究中心,副主任,研究员 2010年9月-2014年5月,中科院昆明动物研究所,生殖与发育生物学实验室,副研究员 2007年4月-2010年9月,中科院昆明动物研究所,生殖与发育生物学实验室,助理研究员

研究领域

1.基因组编辑技术构建人类重大疾病的灵长类动物模型 2.灵长类动物早期胚胎发育与细胞的重编程

近期论文

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1.Wan H, Feng C, Teng F, Yang S, Hu B, Niu Y, Xiang AP, Fang W, Ji W, Li W, Zhao X, Zhou Q*. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. 2015. Cell Research. Feb; 25(2):258-61. doi: 10.1038/cr.2014.158. [Epub ahead of print] 2.Niu Y#, Shen B#, Cui Y#, Chen Y#, Wang J, Wang L, Kang Y, Zhao X, Si W, Li W, Xiang AP, Zhou J, Guo X, Bi Y, Si C, Hu B, Dong G, Wang H, Zhou Z, Li T, Tan T, Pu X, Wang F, Ji S, Zhou Q, Huang X*, Ji W*, Sha J*. Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos. 2014. Cell, Volume 156, Issue 4, 836-843 3.Niu Y#, Guo X#, Chen Y#, Wang CE, Gao J, Yang W, Kang Y, Si W, Wang H, Yang SH, Li S, Ji W*, Li XJ*. Early Parkinson's disease symptoms in α-synuclein transgenic monkeys. 2014. Hum Mol Genet. Dec 30. pii: ddu748. [Epub ahead of print] 4.Yongchang Chen#, Yiqiang Cui#, Bin Shen#, Yuyu Niu#, Xiaoyang Zhao, Lei Wang, Jianying Wang, Wei Li, Qi Zhou, Weizhi Ji*, Jiahao Sha* and Xingxu Huang*. Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys. 2014. Cell Research. 10.1038/cr.2014.167 [Epub ahead of print] 5.Liu H#, Chen Y#, Niu Y#, Zhang K, Kang Y, Ge W, Liu X, Zhao E, Wang C, Lin S, Jing B, Si C, Lin Q, Chen X, Lin H, Pu X, Wang Y, Qin B, Wang F, Wang H, Si W, Zhou J, Tan T, Li T, Ji S, Xue Z, Luo Y, Cheng L, Zhou Q, Li S*, Sun YE*, Ji W*. TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys. 2014. Cell Stem Cell, Volume 14, Issue 3, 323-328 6.Tan T, Lu B, Zhang J, Niu YY, Si W, Wei Q, Ji WZ* Notch1 Signaling Antagonizes Transforming Growth Factor-β Pathway and Induces Apoptosis in Rabbit Trophoblast Stem Cells. 2014. Stem Cells and Development. 23(8):813-822. 7.Fan Y, Huang ZY, Cao CC, Chen CS, Chen YX, Fan DD, He J, Hou HL, Hu L, Hu XT, Jiang XT, Lai R, Lang YS, Liang B, Liao SG, Mu D, Ma YY, Niu YY, Sun XQ, Xia JQ, Xiao J, Xiong ZQ, Xu L, Yang L, Zhang Y, Zhao W, Zhao XD, Zheng YT, Zhou JM, Zhu YB, Zhang GJ*, Wang J*, Yao YG*. 2013. Genome of the Chinese tree shrew. Nat Commun. 4:1426. doi: 10.1038/ncomms2416. 8.Chen Y, Niu Y*, Ji W*. Transgenic nonhuman primate models for human diseases:approaches and contributing factors. 2012. J Genet Genomics. 39(6): 247-251. 9.Yongchang Chen#, Yuyu Niu#, Shihua Yang, Xiechao He, Shaohui Ji, Wei Si, Xianghui Tang, Yunhua Xie, Hong Wang, Yongqing Lv, Qi Zhou* and Weizhi Ji*. The Available Time Window for Embryo Transfer in the Rhesus Monkey (Macaca mulatta). 2012. American journal of Primatology. Volume 74, Issue 2, 165–173 10.Chen Y, Wang Z, Xie Y, Guo X, Tang X, Wang S, Yang S, Chen K, Niu Y, Ji W*. Folic acid deficiency inhibits neural rosette formation and neuronal differentiation from rhesus monkey embryonic stem cells. 2012. J Neurosci Res. 90(7):1382-1391. 11.Yongchang Chen#, Yuyu Niu#, Shaohui Ji, Xiechao He, Xianghui Tang, Weizhi Ji*. Initiation Timing Cannot Predict Success of Superovulation in Rhesus Monkeys (Macaca mulatta). 2011. Journal of Animal and Veterinary Advances. 10(24),3293-3296. 12.Yongchang Chen#, Shaohui Ji#, Yuyu Niu#, Xiechao He, Yunhua Xie,Xianghui Tang, Weizhi Ji*. Recombinant Human Gonadotropins for Rhesus Monkey Superovulation:Age and the Stimulation Interval Are Determinant to the Fecundity. 2011. Journal of Animal and Veterinary Advances. 10(24), 3303-3307. 13.Tan T, Tang X, Zhang J, Niu Y, Chen H, Li B, Wei Q, Ji W*. Generation of Trophoblast Stem Cells from Rabbit Embryonic Stem Cells with BMP4. 2011. PLoS One. ;6(2):e17124. 14.Yang S, Ping S, Si W, He X, Wang X, Lu Y, Ji S, Niu Y, Ji W*. Optimization of ethylene glycol concentrations, freezing rates and holding times in liquid nitrogen vapor for cryopreservation of rhesus macaque (Macaca mulatta) sperm. 2011. J Vet Med Sci. 73(6):717-23. 15.Yang S, Ping S, Ji S, Lu Y, Niu Y, Wang H, Ji W, Si W*. The positive effects of seminal plasma during the freezing process on cryosurvival of sperm with poor freezability in the rhesus macaque (Macaca mulatta). 2011. J Reprod Dev. 57(6):737-43. 16.Yuyu Niu#, Yang Yu#, Agnieszka Bernat#, Shihua Yang, Xiechao He, Xiangyu Guo, Dongliang Chen, Yongchang Chen, Shaohui Ji, Wei Si, Yongqin Li, Tao Tan, QiangWei, Hong Wang, Lei Shi, Jean Guan, Xuemei Zhu, Marielle Afanassieff, PierreSavatier*, Kang Zhang*, Qi Zhou*, Weizhi Ji*. Transgenic rhesus monkeys produced by gene transfer into early cleavage stage embryos using a simian immunodeficiency virus-based vector. 2010. Proc Natl Acad Sci U S A. 107(41):17663-17667. 17.Si W, Lu Y, He X, Ji S, Niu Y, Tan T, Ji W*. Directional freezing as an alternative method for cryopreserving rhesus macaque (Macaca mulatta) sperm. 2010. Theriogenology. 74(8):1431-1438. 18.Wang Y, Hai T, Liu Z, Zhou S, Lv Z, Ding C, Liu L, Niu Y, Zhao X, Tong M, Wang L, Jouneau A, Zhang X, Ji W, Zhou Q*. HSPC117 deficiency in cloned embryos causes placental abnormality and fetal death. 2010. Biochem Biophys Res Commun. 397(3):407-412 19.S. Yang, X. He, Y. Niu, T.B. Hildebrandt, K. Jewgenow, F. Goeritz, X. Tang, Y. Chang, Q. Zhou*, W. Ji* Ovarian response to gonadotropin stimulation in juvenile rhesus monkeys. 2009. Theriogenology. 72:243-250. 20.S. Yang, X. He, Y. Niu, X. Wang, B. Lu, T.B. Hildebrandt, F. Goeritz, K. Jewgenow, Q. Zhou, W. Ji* Dynamic changes in ovarian follicles measured by ultrasonography during gonadotropin stimulation in rhesus monkeys. 2009. Theriogenology. 72:560-565.

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