孙宏晨 - 吉林大学 - 超分子结构与材料国家重点实验室

个人简介

孙宏晨教授1963年12月出生于哈尔滨，1998年获得白求恩医科大学医学博士学位，随后在吉林大学超分子结构与材料国家重点实验室从事博士后研究，先后以国家公派访问学者和高级研究学者身份赴日本东京医科齿科大学及美国密歇根大学从事合作研究。2016年1月加入吉林大学超分子结构与材料国家重点实验室，任教授、博士生导师。2015年被遴选为长白山学者特聘教授。

研究领域

主要是基于医学领域的科学问题，根据病理微环境特点，设计合成对微环境响应的新型纳米材料，通过研究纳米材料同细胞及其亚细胞结构的相互作用，阐明其在机体内的运输过程，进一步利用或调控微环境开展人类疾病诊断和治疗研究。具体研究工作：1）构筑对病理微环境响应的纳米复合材料；2）研究纳米微粒体内运输过程对机体生物学功能的影响；3）阐述纳米微粒跨生物膜转运的生物学作用；4）研制开发医学微尺度诊治技术和生物材料。

近期论文

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1. Zhu, Y.; Li, D. W.; Zhang, K.; Jiang, L. M.; Sun, H.C.*, et al. Novel Synthesized Nanofibrous Scaffold Efficiently Delivered hBMP-2 Encoded in Adenoviral Vector to Promote Bone Regeneration. Journal of Biomedical Nanotechnology, 2017, (10): 437-446. 2. Xu, X. W.; Zhang, K.; Zhao, L.; Li, C.; Sun, H.C.*, et al. Aspirin-Based Carbon Dots, a Good Biocompatibility of Material Applied for Bioimaging and Anti-Inflammation. ACS Applied Materials & Interfaces, 2016, 8 (48), 32706–32716. 3. Shi, C.; Zhang, H.H; Louie, K.; Mishina, Y.J.*; Sun, H. C.*, et al. BMP Signaling Mediated by BMPR1A in Osteoclasts Negatively Regulates Osteoblast Mineralization Through Suppression of Cx43. Journal of Cellular Biochemistry. 2016, 3(118): 605-614. 4. Sun, B.; Zhao, B.; Wang, D. D.; Wang, Y. B.; Sun, H. C.*, et al. Fluorescent Non-Conjugated Polymer Dots for Targeted Cell Imaging. Nanoscale, 2016, 8(18): 9837-9841. 5. Shi, C.; Lura, A.; Terajima, M.; Mishina, Y. J.; Sun, H. C.* , et al. Deletion of BMP Receptor Type IB Decreased Bone Mass in Association with Compromised Osteoblastic Differentiation of Bone Marrow Mesenchymal Progenitors. Scientific Reports. 2016, 6: 24256. 6. Zhao, L.; Zhang, K.; Bu, W.; Xu, X. W.; Sun, H. C.*, et al. Effective Delivery of Bone Morphogenetic Protein 2 Gene Using Chitosan–Polyethylenimine Nanoparticle to Promote Bone Formation. RSC Advances, 2016, 6(41): 34081-34089. 7. Li, C.; Shi, C.; Kim, J.; Chen, Y.; Sun, H. C.*, et al. Erythropoietin Promotes Bone Formation through Ephrinb2/Ephb4 Signaling. J. Dent. Res. 2015, 94, 455-463. 8. Li, D. W.; Sun, H. Z.; Jiang, L. M.; Zhang, K.; Sun, H. C.*; et al. Enhanced Biocompatibility of Plga Nanofibers with Gelatin/Nano-Hydroxyapatite Bone Biomimetics Incorporation. ACS Appl. Mater. Interfaces 2014, 6, 9402-9410. 9. Jin, H.; Zhang, K.; Qiao, C. Y.; Yuan, A. L.; Sun, H. C.*, et al. Efficiently Engineered Cell Sheet Using a Complex of Polyethylenimine-Alginate Nanocomposites Plus Bone Morphogenetic Protein 2 Gene to Promote New Bone Formation. Int. J. Nanomedicine 2014, 9, 2179-2190. 10. Miao, L. Y.; Zhang, K.; Qiao, C. Y.; Jin, X. Y.; Sun, H. C.* , et al. Antitumor Effect of Human Trail on Adenoid Cystic Carcinoma Using Magnetic Nanoparticle-Mediated Gene Expression. Nanomed. 2013, 9, 141-150.