赵晨阳 - 中国海洋大学

个人简介

博士, 中国海洋大学“英才工程”一层次教授；青岛海洋生物医药研究院研究员、项目科学家。兰州大学博士、法国巴黎第七大学博士。2005-2016年在美国克利夫兰医学中心学习、工作。

研究领域

主要研究炎症反应中巨噬细胞极化的分子机理、调控方式及其与肿瘤发生发展之间的关系、TLRs信号通路与细胞应激反应之间的相互作用关系、炎症及应激反应中细胞因子、趋化因子mRNA稳定性的调控机制等。重点关注TLR3/4信号通路与细胞应激的协同作用、IRAK2、TTP等调控细胞因子稳定性的作用机制等。同时构建靶向巨噬细胞功能调节的关键靶基因的高通量药物筛选平台，筛选与巨噬细胞功能有重要关联的抗炎症、抗肿瘤先导化合物。

近期论文

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Jingjie Sun, Yuping Du , Qiaoling Song, Jing Nan, Peizhu Guan, Jihui Guo, Xiao Wang, Jinbo Yang* and Chenyang Zhao*. E2F is required for STAT3-mediated upregulation of cyclin B1 and Cdc2 expressions and contributes to G2-M phase transition. Acta Biochim Biophys Sin, 2019, 51(3): 313-322. He Ma, Peiju Qiu, Meng Xin, Ximing Xu, Zhuoya Wang, Huixin Xu, Rilei Yu, Xiaoxiao Xu, Chenyang Zhao, Xin Wang, Huashi Guan, Jinbo Yang, and Chunxia Li. Structure-activity relationship of propylene glycol alginate sodium sulfate derivatives for blockade of selectins binding to tumor cells. Carbohydrate Polymers, 2019, 210:225-233. Datta Shyamasree, Natilibeth Barrera, Paul G. Jr. Pavicic, Chenyang Zhao, Michael Freeman, Booki Min, and Thomas Hamilton. cEBP Homologous Protein Expression in Macrophages Regulates the Magnitude and Duration of IL-6 Expression and Dextran Sodium Sulfate Colitis. Journal of Interferon & Cytokine Research, 2015, 35(10): 785-794. Thomas Hamilton, ChenyangZhao, Pavicic Paul G. Jr.,Datta Shyamasree. Myeloid colony-stimulating factors as regulators of macrophage polarization. Frontiers in Immunology, 2014, 5: 554. Chenyang Zhao, Paul G. Pavicic Jr., Shyamasree Datta, Dongxu Sun, Michael Novotny, Thomas Hamilton. Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1. J Immunology, 2014, 193:879-888. Thomas Hamilton, Xiaoxia Li, Michael Novotny, Paul G. Pavicic Jr., Shyamasree Datta, Chenyang Zhao, Justin Hartupee, Dongxu Sun. Cell type- and stimulus-specific mechanisms for post-transcriptional control of neutrophil chemokine gene expression. Journal of Leukocyte Biology, 2012, 91:377-383. Thomas Hamilton, Michael Novotny, Paul G. Pavicic, Jr., Tomasz Herjan, Justin Hartupee, Dongxu Sun, Chenyang Zhao, Shyamasree Datta. Diversity in post-transcriptional control of neutrophil chemoattractant cytokine gene expression. Cytokine, 2010, 52:116-122. Chenyang Zhao,Shyamasree Datta, Palash Mandal, Shuqin XU and Thomas A. Hamilton. Stress-sensitive regulation of IFRD1 mRNA decay is mediated by an upstream ORF.Journal of Biological Chemistry, 2010, 285: 8552-8562. Rongliang Zheng, Yimin Shi, Zhongjian Jia, Chenyang Zhao, Qi Zhang and Xiaorong Tan. Fast repair of DNA radicals. Chemical Society Reviews, 2010, 2010, 39(8): 2827-2834. Shyamasree Datta, Michael Novotny, Paul G. Pavicic, Jr., Chenyang Zhao, Tomasz Herjan, Justin Hartupee, and Thomas Hamilton. Interleukin-17 regulates CXCL1 mRNA stability via an AUUUA/Tristetraprolinindependent sequence. Journal of Immunology,2010, 184: 1484-1491. Chenyang Zhao andThomas A. Hamilton. Introns regulate the rate of unstable mRNA decay. Journal of Biological Chemistry, 2007, 282: 20230-20237. Chenyang Zhao, Guy Dodin, Chenshan Yuan, Haifeng Chen, Rongliang Zheng, Zhongjian Jia and Botao Fan. “In vitro” protection of DNA from Fenton reaction by plant polyphenol verbascoside. Biochimica et Biophysica Acta, 2005, 1723: 114-123. Haifeng Chen, Botao Fan, Chenyang Zhao, Lan Xie, Chunhong Zhao, Ting Zhou, Kuo-Hsiung Lee and Graham Allaway. Computational studies and drug design for HIV-1 reverse transcriptase inhibitors of 3',4'-di-O-(S)-camphanoyl-(+)-cis- -khellactone (DCK) analogs. Journal of Computer-Aided Molecular Design, 2005, 19: 243-258. Chenyang Zhao, Yimin Shi, Wenfeng Wang, Zhongjian Jia, Side Yao, Botao Fan and Rongliang Zheng. Fast repair of deoxythymidine radical anions by two polyphenols: rutin and quercetin. Biochemical Pharmacology, 2003, 65: 1967-1971.