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王敏,应用化学系教授,博士生导师,硕士生导师,1988年开始在中国农业大学任教,1993年开始享受国务院特殊津贴,主要研究方向为不对称合成。承担《农药合成化学》,《不对称合成》,《农药学Siminar》等课程教学工作。曾获国家教委科技进步一等奖、第四届北京青年优秀科技论文二等奖,取得多项专利。 科研项目 《含环丙烷单元双噁唑啉手性配体的合成与催化性能研究》,国家自然科学基金(基金号:20472111),2005,1~2007,12,主持人 《基于环丙烷骨架的手性配体的设计、合成及性能研究》,国家自然科学基金(基金号:20742004),2008,1~2008,12,主持人 《农药过程化关键技术的开发》,国家“十一五”支撑计划,陈建忠(杭州庆丰农化有限公司),王敏(课题负责人),2006,11~2008,10 《乙氰菊酯创新工艺研究》,国家“十五”攻关项目(项目编号:2004BA308A19-5),戚明珠(扬农股份),王敏(技术负责人),2003,1~2005,12

研究领域

不对称合成

近期论文

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Na, R. S.; Jing, C. F.; Xu, Q. H.; Jiang, H.; Wu, X.; Shi, J.Y.; Zhong, J. C.; Wang, M.; Benitez, D.; Tkatchouk, E.; Goddard, W. A.; Guo, H. C.; Kwon, O. Phosphine-Catalyzed Annulations of Azomethine Imines: Allene-Dependent [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] Pathways, J. Am. Chem. Soc. 2011, 133, 13337–13348. Li, Z. Y.; Wang, M.; Bian, Q. H.; Zheng, B.; Mao, J. Y.; Li, S. N.; Liu, S. Z.; Wang, M. A; Zhong, J. C.; Guo, H. C. Highly Enantioselective Addition of Trimethylsilylacetylene to Aldehydes Catalyzed by Zinc-Amino Alcohol Complex, Chem. Eur. J. 2011, 17, 5782 -5786. Zhong, J. C.; Hou, S. C.; Bian, Q. H.; Yin, M. M.; Na, R. S.; Zheng, B. ; Li, Z. Y.; Liu, S. Z.; Wang, M.* Highly Enantioselective Zinc/Amino Alcohol-Catalyzed Alkynylation of Aldehydes, Chem. Eur. J. 2009, 15, 3069 – 3071. Zheng, B.; Hou, S. C.; Li, Z. Y.; Guo, H. C.; Zhong, J. C.; Wang, M.* Enantioselective Synthesis of Quaternary Stereogenic Centers Through Catalytic Asymmetric Addition of Dimethylzinc to α-Ketoesters with Chiral cis-Cyclopropane-based Amide Alcohol as Ligand, Tetrahedron: Asymmetry 2009, 20, 2125 – 2129. Zhong, J. C.; Wang, M. A.; Guo, H. C.; Yin, M. M.; Wang, M.* Asymmetric Diethylzinc Addition and Phenyl Transfer to Aldehydes Using Chiral cis-Cyclopropanebased Amino Alcohols, Tetrahedron:Asymmetry 2007, 18, 734 – 741. Gao J. S.; Guo, H. C.; Liu, S. Z.; Wang, M.* Efficient Soluble Polymer-supported Tartrate/Ti Catalyst for Asymmetric Oxidation of Prochiral Sulfides. Tetrahedron Lett. 2007, 48, 8453 – 8455. Tan, X. L.; Hou, S. C.; Wang, M.* Enantioselective and Diastereoselective Separation of Synthetic Pyrethroid Insecticides on a Novel Chiral Stationary Phase by High-performance Liquid Chromatography, Chirality 2007, 19, 574 – 580. Tan, X. L.; Hou, S. C.; Jiang, J. L.; Wang, M.* Preparation of a New Chiral Stationary Phase for HPLC Based on the (R)-1-Phenyl-2-(4-methylphenyl) Ethylamine Amide Derivative of (S)-Valine and 2-Chloro-3,5-Dinitrobenzoic Acid: Enantioseparation of Amino Acid Derivatives and Pyrethroid Insecticides, J. Sep. Sci. 2007, 30, 1888 – 1892. Zhong, J. C.; Wang, M. A.; Guo, H. C.; Bian, Q. H. ; Wang M.* Design and Synthesis of 1,4-Amino Alcohol Ligands with a Chiral Cyclopropane Backbone for Asymmetric Diethylzinc Addition to Aromatic Aldehydes, Synlett 2006, 1667 – 1670. Guo, H. C.; Shi, X. Y.; Wang, X.; Liu, S. Z.; Wang, M.* Liquid-Phase Synthesis of Chiral Tartrate Ligand Library for Enantioselective Sharpless Epoxidation of Allylic Alcohols , J. Org. Chem. 2004, 69, 2042 – 2047. Wang, M.; Liu, S. Z.; Liu, J.; Hu, B. F. The Diastrreoselective Synthesis of 1,1- Binaphthyl -2,2’-diol, J. Org. Chem. 1995, 60, 7364 – 7365. Guo, H. C.; Shi, X. Y.; Qiao, Z.; Hou, S. C.; Wang, M.* Efficient Soluble Polymer- supported Sharpless Alkene Epoxiidation Catalyst, Chem. Commun. 2002, 118 – 119. Zhong, J. C.; Wang, M.-A.; Wang, M.* {(1R,3S)-3-[(Dimethylamino)methyl]-2, 2-dimethyl-cyclo- propyl}diphenylmethanol, Acta Cryst. 2007, E63, 1058 – 1059. Shi, X. Y.; Guo, H. C.; Wang, M.* Enantioseparation of Chiral Epoxides Using Four New Cyclodextrin Derivatives as Chiral Stationary Phases of Capillary Gas Chromatograp, Anal. Chim. Acta 2005, 553, 43 – 49. Shi, X. Y.; Wang, M.; Chen, G. R.; Fu, R. L.; Gu, J. L. Synthesis and Properties of New Cyclodextrin Phenyl Carbamates as Capillary Gas Chromatography Stationary Phase, Anal. Chim. Acta 2001, 445, 221 – 228. Shi, X. Y.; Guo, H. C.; Wang, M .*; Jiang, S. R. Synthesis of Three New Cyclodextrin Derivatives and Their Application as Chiral Stationary Phases in Determination of Opitical Purity by Capillary Gas Chromatography, Chromatographia 2002, 55, 755 – 759. Shi, X. Y.; Guo, H.C.; Wang, M.*; Jiang, S. R. Capilary Gas Chromatography Separation of Pyrethroic Acids Methyl Esters Using Four Acylated Cyclodextrin Derivatives as Chiral Stationary Phases, Chromatographia 2002, 56, 207 – 211. Hou, S. C.; Zhou, Z. Q.; Qiao, Z. ; Guo, H. C.; Shi, X. Y.; Wang , M.* Enantiomer Separation of Tebuconazole and Its Potential Impurities by High Performance Liquid Cromatography Using Cellulose Derivative-based Chiral Stationary Phase, Chromatographia 2003, 57, 177 – 180. Yin, M. M.; Li, N.; Shi, X. Y.; Wang, M.* Synthesis of Some Allyl-β-cyclodextrin Derivatives and Their Properties as Capillary GC Stationary Phases, Chromatographia 2003, 58, 301 – 305.

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