安杰 - 中国农业大学 - 营养与健康系（营养与健康研究院）

个人简介

2019.01至今：中国农业大学教授、青年科学家创新团队负责人 2015.04-2018.12：中国农业大学副教授 2013.08-2015.04：曼彻斯特大学合成化学博士后 2009.09-2013.07：诺丁汉大学合成化学博士 2005.09-2009.07：中国农业大学理学学士

研究领域

1. 新材料与人类健康利用Click Chemistry，光催化反应等最新合成技术制备生物医用材料和具有特殊功能的表面材料；研究内容涉及：组织修复水凝胶材料、柔性可植入智能材料、抗菌表面材料、超疏水表面材料等。 2. 绿色化学与药物研发建立符合绿色化学理念的新型合成方法，特别是新型氘标记化合物合成方法；并以新型合成方法为基础开发氘代药物及疾病诊断试剂。

近期论文

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In press, Luo, T.; Li, L.; Chen, Y.; An, J.*; Liu, C.; Yan, Z.; Carter, J. H.; Han, X.; Sheveleva, A. M.; Tuna, F.; McInnes, E. J. L.; Tang, C. C.; Schr?der, M.*; Yang, S.* Construction of C-C bonds via photoreductive coupling of ketones and aldehydes in the metalorganic-framework MFM-300(Cr), Nature Communications Li, H.; Peng, M.; Lai, Z.; Ning, L.; Chen, X.; Zhang, X.; Wang, P.; Szostak, R.; Szostak, M.*; An, J.* Acyl Fluorides as Direct Precursors to Fluoride Ketyl Radicals: Reductive Deuteration using SmI2 and D2O. Chem. Comm. 2021, doi.org/10.1039/D1CC01381E Ning, L.; Li, H; Lai, Z.; Szostak, M.; Chen, X.; Dong, Y.*; Jin, S.; An, J.* Synthesis of α?Deuterated Primary Amines via Reductive Deuteration of Oximes Using D2O as a Deuterium Source. J. Org. Chem. 2021, 86, 2907-2916. Luo, S.; Weng, C.; Ding, Y.; Ling, C.; Szostak, M.; Ma, X.*; An, J.* Reductive Deuteration of Aromatic Esters for the Synthesis of α,α-Dideuterio Benzyl Alcohols Using D2O as Deuterium Source. Synlett 2021. 32(01), 51-56. Li, H.; Hou, Y.; Liu, C.; Lai, Z.; Ning, L.; Szostak, R.; Szostak, M.*; An, J.* Pentafluorophenyl Esters: Highly Chemoselective Ketyl Precursors for the Synthesis of α,α-Dideuterio Alcohols Using SmI2 and D2O as a Deuterium Source. Org. Lett. 2020, 22 (4), 1249–1253. Fan, X.; Han, M.; Ding, Y.; Zhang, X.; Li, H.*; An, J.* Synthesis and fungicidal activity of deuterated pefurazoate. Chinese Journal of Pesticide Science. 2020, 22 (1), 27-34. Lei, P.; Ling, Y.; An, J.; Nolan, S. P.; Szostak, M. Adv. Synth. Catal. 2019, 361 (24), 5654. Ding, Y.; Luo, S.; Ma, L.*; An, J.* Reductive Cleavage of Unactivated Carbon–Cyano Bonds under Ammonia-Free Birch Conditions. J. Org. Chem. 2019, 84 (24), 15827–15833. Ding, Y.; Luo, S.; Weng, C.; An, J.* Reductive Deuteration of Nitriles Using D2O as a Deuterium Source. J. Org. Chem. 2019, 84 (23), 15098–15105. Li, H; Lai, Z.; Adijiang, A.; Zhao, H.; An, J.* Selective C-N σ Bond Cleavage in Azetidinyl Amides under Transition Metal-Free Conditions. Molecules 2019, 24 (3), 459. Invited contribution to a special edition “amide bond activation”; guest editor: Prof. Dr. Michal Szostak. Ding, Y.; Luo, S.; Adijiang, A.; Zhao, H.; An, J.* Reductive Deuteration of Nitriles: The Synthesis of α,α-Dideuterio Amines by Sodium-Mediated Electron Transfer Reactions. J. Org. Chem. 2018, 83 (19), 12269-12274. Lei, P.; Ding, Y.; Zhang, X.; Adijiang, A.; Li, H.; Ling, Y.; An, J.* A Practical and Chemoselective Ammonia-Free Birch Reduction. Org. Lett. 2018, 20, 3439-3442. Zhang, B.; Li, H.; Ding, Y.; Yan, Y.; An, J.* Reduction and Reductive Deuteration of Tertiary Amides Mediated by Sodium Dispersions with Distinct Proton Donor-Dependent Chemoselectivity. J. Org. Chem. 2018, 83 (11), 6006–6014. Han, M.; Ding, Y.; Yan, Y.; Li, H.; Luo, S.; Adijiang, A.; Ling, Y.; An, J.* Transition-Metal-Free, Selective Reductive Deuteration of Terminal Alkynes with Sodium Dispersions and EtOD ? d 1. Org. Lett. 2018, 20, 8–11. Lei, P.; Meng, G.; Shi, S.; Ling, Y.; An, J.; Szostak, R.; Szostak, M.* Suzuki–Miyaura Cross-Coupling of Amides and Esters at Room Temperature: Correlation with Barriers to Rotation around C–N and C–O Bonds. Chem. Sci. 2017, 8, 6525–6530. Lei, P.; Meng, G.; Ling, Y.; An, J.; Szostak, M.* Pd-PEPPSI: Pd-NHC Precatalyst for Suzuki-Miyaura Cross-Coupling Reactions of Amides. J. Org. Chem. 2017, 82 (13), 6638–6646. Lei, P.; Meng, G.; Ling, Y.; An, J.; Nolan, S. P.; Szostak, M.* General Method for the Suzuki-Miyaura Cross-Coupling of Primary Amide-Derived Electrophiles Enabled by [Pd(NHC)(Cin)Cl] at Room Temperature. Org. Lett. 2017, 19 (24), 6510–6513. Li, H.; Zhang, B.; Dong, Y.; Liu, T.; Zhang, Y.; Nie, H.; Yang, R.; Ma, X.; Ling, Y.; An, J.* A Selective and Cost-Effective Method for the Reductive Deuteration of Activated Alkenes. Tetrahedron Lett. 2017, 58 (28), 2757–2760. Han, M.; Ma, X.; Yao, S.; Ding, Y.; Yan, Z.; Adijiang, A.; Wu, Y.; Li, H.; Zhang, Y.; Lei, P.; An, J.* Development of a Modified Bouveault–Blanc Reduction for the Selective Synthesis of α,α-Dideuterio Alcohols. J. Org. Chem. 2017, 82 (2), 1285–1290. Fearnley, A. F.; An, J.; Jackson, M.; Lindovska, P.; Denton, R. M.* Synthesis of Quaternary Aryl Phosphonium Salts: Photoredox-Mediated Phosphine Arylation. Chem. Commun. 2016, 52 (28), 4987–4990. An, J.; Work, D. N.; Kenyon, C.; Procter, D. J.* Evaluating a Sodium Dispersion Reagent for the Bouveault-Blanc Reduction of Esters. J. Org. Chem. 2014, 79 (14), 6743–6747. An, J.; Denton, R. M.*; Lambert, T. H.*; Nacsa, E. D. The Development of Catalytic Nucleophilic Substitution Reactions: Challenges, Progress and Future Directions. Org. Biomol. Chem. 2014, 12 (19), 2993. Tang, X.; An, J.; Denton, R. M.* A Procedure for Appel Halogenations and Dehydrations Using a Polystyrene Supported Phosphine Oxide. Tetrahedron Lett. 2014, 55 (4), 799–802. An, J.; Denton, R. M. Heteroatom Methods. Annu. Reports Sect. “B” (Organic Chem. 2013, 109, 167. An, J.; Tang, X.; Moore, J.; Lewis, W.; Denton, R. M. Phosphorus(V)-Catalyzed Deoxydichlorination Reactions of Aldehydes. Tetrahedron 2013, 69 (41), 8769–8776. Denton, R. M.*; An, J.; Lindovska, P.; Lewis, W. Phosphonium Salt-Catalysed Synthesis of Nitriles from in Situ Activated Oximes. Tetrahedron 2012, 68 (13), 2899–2905. Denton, R. M.*; An, J.; Adeniran, B.; Blake, A. J.; Lewis, W.; Poulton, A. M. Catalytic Phosphorus ( V ) -Mediated Nucleophilic Substitution Reactions?: Development of a Catalytic Appel Reaction. J. Org. Chem. 2011, 76 (V), 6749–6767. Denton, R. M.*; An, J.; Adeniran, B. Phosphine Oxide-Catalysed Chlorination Reactions of Alcohols under Appel Conditions. Chem Commun 2010, 46, 3025–3027.