张梦晖 - 上海交通大学 - 生命科学技术学院

个人简介

1990 年在中国药科大学药学院药理专业获药学学士学位；1999年至2005年在比利时布鲁塞尔自由大学学习，先后获得药学硕士、药学博士学位。 1990至1998 年在湖南省药检所工作，主要从事药品监督、生物检定及新药药效学、毒理学评价；1998至1999 年作为日中医学奖学金研修生由卫生部公派至日本富山医科药科大学和汉药研究所从事痴呆模型与抗痴呆中草药研究；1999至2005 年在比利时布鲁塞尔自由大学师从D.L.Massart 教授，专攻化学计量学，偏重于医、药学数据分析的方法学研究。2005 年底至今在上海交通大学生命科学技术学院主要从事系统生物学研究中计算生物学部分的工作，重点为数据分析及生物信息挖掘。

研究领域

多变量数据分析, 生物信息学

近期论文

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T. Wang, G. Cai, Y. Qiu, N. Fei, M. Zhang, X. Pang, W. Jia, S. Cai, L. Zhao, Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers ， ISME J., doi:10.1038/ismej.2011.109 T. Wang, X. Zhang, M. Zhang, L. Wang, L. Zhao L, Development of a fluorophore-ribosomal DNArestriction typing method for monitoring structural shifts of microbial communities, Arch Microbiol. ,193(5):341-50, 2011 H. Wei, L. Dong, T. Wang, M .Zhang, W.Hua, C. Zhang, X.Pang, M. Chen, M. Su, Y. Qiu, M. Zhou, S.Yang, Z. Chen, M. Rantalainen5, J. K. Nicholson, W. Jia, D. Wu , L. Zhao, Structural shifts of gutmicrobiota as surrogate endpoints for monitoring host health changes induced by carcinogen exposure, FEMS Microbiol Ecol 73 (2010) 577–586 C. Zhang ，M. Zhang ，S. Wang ，R. Han ，Y. Cao，W. Hua，Y. Mao，X. Zhang， X. Pang, C. Wei, G. Zhao, Y. Chen, L. Zhao，Interactions between gut microbiota, host genetics, and diet relevant to development of metabolic syndromes in mice, ISME Journal, 2010 Feb;4(2):232-41 M. Zhang, M. Zhang*, C. Zhang, H. Du, G Wei, X.Pang, H. Zhou, B. Liu, L. Zhao, Pattern extraction of structural responses of gut microbiota to rotavirus infection via multivariate statistical analysis of clone library data, FEMS Microbiol Ecol., 70（2009）:177-185（*corresponding author） M. Li*，B. Wang*, M.H. Zhang*, M. Rantalainen*, S. Wang*, et al., Symbiotic gut microbes modulate human metabolic phenotypes, PNAS, 105 (2008) 2117-2122 (* first co-author) E. Deconinck, M.H. Zhang, F. Petitet, E. Dubus, I. Ijjaali, D. Coomans and Y. Vander Heyden, Boosted regression trees, multivariate adaptive regression splines and their two-step combinations with multiple linear regression or partial least squares to predict blood–brain barrier passage: A case study, Anal. Chimi. Acta , 609 (2008) 13-23 E. Deconinck, M.H. Zhang, D. Coomans and Y. Vander Heyden, Evaluation of boosted regression trees (BRT) and two-step BRT procedures to model and predict blood-brain barrier passage，Journal of Chemometrics，21（2007）280-291 E. Deconinck, M.H. Zhang, D. Coomans and Y. Vander Heyden, Classification tree models for the prediction of blood-brain barrier passage of drugs, J. Chem. Inf. Model., 46(2006) 1410-1419 M.H. Zhang, Q.S. Xu, D.L. Massart, Boosting PLS, Anal. Chem., 77(2005) 1423-1431 M.H. Zhang, Q.S. Xu, D.L. Massart, Application of boosting to classification problems in chemometrics, Anal. Chimi. Acta, 544(2005) 167-176 M.H. Zhang, Q.S. Xu, D.L. Massart, Averaged and weighted average Partial Least Squares, Anal. Chimi. Acta, 504 (2004) 279-289 M.H. Zhang, Q.S. Xu, D.L. Massart, Robust Principal Components Regression based on Principal Sensitivity Vectors, Chemo. Intell. Lab. Sys., 67 (2003) 175-185 M.H. Zhang, J. Luypaert, J.A. Fernandez Pierna, Q.S. Xu, D.L. Massart, Determination of total antioxidant capacity in green tea by near-infrared spectroscopy and multivariate calibration, Talanta, 62 (2004) 25-35 J. Luypaert, M.H. Zhang, D.L. Massart, A feasibility study for the use of near infrared spectroscopy (NIR) in the qualitative and quantitative analysis of plants with antioxidant capacity, Anal. Chimi. Acta, 478 (2003) 303-312