赵立平 - 上海交通大学 - 系统生物医学研究院

个人简介

教育经历 1993.9-1995.9 美国康奈尔大学植物系访问学者 1983.9-1989.3 南京农业大学植物病理学系博士工作经历 2013-今上海交通大学生命科学与技术学院教授 2005-今上海系统生物医学研究中心副主任 2003-2013 上海交通大学生命科学与技术学院教授、副院长 2001-2003 上海交通大学生物技术系教授、系主任 2000.4-2000.7 美国加州大学Riverside分校植物病理学系南卡大学环境工程系访问教授 1997-2001 山西大学生物工程研究所教授、所长 1995.9-1997 山西大学生物工程研究所副教授 1989.3-1993.9 山西农科院生物工程研究室副主任

研究领域

1.微生物分子生态学：微生物群落的结构解析新技术，微生物群落元基因组学 2.人体系统生物学：肠道菌群结构和功能变化与代谢性疾病发生发展的关系 3.多元统计与生物信息在微生物生态学领域的应用研究

近期论文

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Fei N, Zhao LP*. An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice. ISME J, 2013, 7(4):880-4. Shen J, Obin MS, Zhao LP*. The gut microbiota, obesity and insulin resistance. Mol Aspects Med, 2013, 34(1):39-58. Zhang X, Zhao Y, Zhang M, Pang X, Xu J, Kang C, Li M, Zhang Y, Zhang Z, Li X, Ning G, Zhao LP*. Structural Changes of Gut Microbiota during Berberine-mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats. Plos One, 2012, 7(8):e42529. Zhao LP*, Nicholson JK*, Lu A, Wang Z, Tang H, Holmes E, Shen J, Zhang X, Li JV, Lindon JC.. Targeting the Human Genome−Microbiome Axis for Drug Discovery: Inspirations from Global Systems Biology and Traditional Chinese Medicine. J Proteome Res, 2012, 11(7): 3509–3519. Zhang C, Zhang M, Pang X, Zhao Y, Wang L and Zhao LP*. Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations.ISME J, 2012, 6(10):1848-57. Wang T, Cai G, Qiu Y, Fei N, Zhang M, Pang X, Jia W, Cai S, Zhao LP*.Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. ISME J, 2012, 6(2):320-9. van Hylckama Vlieg JE, Veiga P, Zhang C, Derrien M, Zhao LP*. Impact of microbial transformation of food on health-from fermented foods to fermentation in the gastro-intestinal tract.. Curr Opin Biotech, 2011, 22(2):211-219. Wei H, Dong L, Wang T, Zhang M, Hua W, Zhang C, Pang X, Chen M, Su M, Qiu Y, Zhou M, Yang S, Chen Z, Rantalainen M, Nicholson J.K., Jia W, Wu D,Zhao LP*. Structural shifts of gut microbiota as surrogate endpoints for monitoring host health changes induced by carcinogen exposure. FEMS Microbiol Ecol, 2010, 73(3):577-586. Zhao LP*, Shen J. Whole-body systems approaches for gut microbiota-targeted, preventive healthcare. J Biotechnol, 2010, 149(3):183-90. Zhang C, Zhang M, Wang S, Han R, Cao Y, Hua W, Mao Y, Zhang X, Pang X, Wei C, Zhao G, Chen Y, Zhao LP*.. Interactions between gut microbiota, host genetics, and diet relevant to development of metabolic syndromes in mice.ISME J, 2010, 4(2): 232-241. Zhang M, Zhang M, Zhang C, Du H, Wei G, Pang X, Zhou H, Liu B, Zhao LP*.Pattern extraction of structural responses of gut microbiota to rotavirus infection via multivariate statistical analysis of clone library data. FEMS Microbiol Ecol,2009, 70(2):21-9. Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, Zhang Y, Shen J, Pang X, Zhang M, Wei H, Chen Y, Lu H, Zuo J, Su M, Qiu Y, Jia W, Xiao C, Smith LM,Yang S, Holmes E, Tang H, Zhao G, Nicholson JK, Li L, Zhao LP*. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A,2008, 105(6):2117-22. Jia W，Li H, Zhao LP & Nicholson JK. Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discov, 2008, 7(2):123-9. Pang X, Hua X, Yang Q, Ding D, Che C, Cui L, Jia W, Bucheli P, Zhao LP*..Inter-species transplantation of gut microbiota from human to pigs. ISME J, 2007, 1(2):156-62. Zhang M, Liu B, Zhang Y, Wei H, Lei Y, Zhao LP*. Structural shifts of mucosa-associated Lactobacilli and Clostridium leptum subgroup in patients with ulcerative colitis. J Clin Microbiol, 2007, 45(2):496-500. Yan X, Xu Z, Feng X, Liu Y, Liu B, Zhang X, Zhu C, Zhao LP*. Cloning of environmental genomic fragments as physical markers for monitoring microbial populations in coking wastewater treatment system. Microb Ecol, 2007, 53(1):163-72. Wei G, Lu H, Zhou Z, Xie H, Wang A, Nelson K, Zhao LP*. The microbial community in the feces of the giant panda (Ailuropoda melanoleuca) as determined by PCR-TGGE profiling and clone library analysis. Microb Ecol,2007, 54(1):194-202. Liu B, Zhang F, Feng X, Liu Y, Yan X, Zhang X, Wang L, Zhao LP*.Thauera and Azoarcus as Functionally Important Genera in a Denitrifying Quinoline Removal Bioreactor as Revealed by Microbial Community Structure Comparison. FEMS Microbiol. Ecol.，2006, 55(2):274-86. Shen J, Zhang B, Wei G, Pang X, Wei H, Li M, Zhang Y, Jia W, Zhao LP*. ?Molecular Profiling of the Clostridium leptum Subgroup in Human Fecal Microflora by PCR-Denaturing Gradient Gel Electrophoresis and Clone Library Analysis.Appl Environ Microbiol, 2006, 72(8):5232-5238. Pang X, Ding D, Wei G, Zhang M, Wang L, Zhao LP*. Molecular profiling of Bacteroides spp. in human feces by PCR-temperature gradient gel electrophoresis. J Microbiol Methods, 2005, 61(3):413-7.