个人简介
朱丹雁 博士，副教授，硕士生导师，毕业于浙江大学药学院，浙江大学 “ 求是青年学者 ” ，浙江省优秀博士后。曾赴美国洛克菲勒大学人口与健康研究中心从事干细胞生物学研究。主要研究领域为干细胞生物学，心血管药理学和药物毒理学。
近年来担任本科药理学、 药物毒理学、 临床药理学、 药物与健康等理论课程和药理学实验教学任务 。指导 SRTP 20 余人，毕业实习学生 10 余人。指导硕士研究生 11 人。主持国家基金等 A 类科研项目 3 项，参加各类科研项目 30 余 项，在国内外学术刊物上发表论文 50 余篇，其中 SCI 收录 30 余 篇。参与获得浙江省科技进步二等奖 1 项，国家发明专利 10 项。参编卫生部 “ 十一五 ” 、 “ 十二五 ” 和“十三五” 规划教材《药物毒理学》第 2 、 3 和 4 版。 获校级教学成果奖培育项目 1 项，并获得校级教学成果奖二等奖 1 项。 发表教改论文 1 篇。
近期论文
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1. Tang LL, Wang JD, Xu TT, Zhao Z, Zheng JJ, Ge RS, Zhu DY*.Mitochondrial Toxicity of Perfluorooctane Sulfonate in Mouse Embryonic Stem Cell-Derived Cardiomyocytes. Toxicology. 2017; 382:108-116.
2. Bei Zheng, Jiadan Wang, Leilei Tang, Chao Tan, Zhe Zhao, Yi Xiao, Renshan Ge, Danyan Zhu*. Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro. Int J Biol Sci. 2017; 13(1): 110-121.
3. BEI ZHENG, JIADAN WANG, LEILEI TANG, JIANA SHI, DANYAN ZHU*. mTORC1 and mTORC2 play different roles in regulating cardiomyocyte differentiation from embryonic stem cells. Int J Dev Biol. 2017; 61(1-2):65-72.
4. Ying-Ying Zhang, Lei-Lei Tang, Bei Zheng, Ren-Shan Ge, Dan-Yan Zhu*. Protein Profiles of Cardiomyocyte Differentiation in Murine Embryonic Stem Cells Exposed to Perfluorooctane Sulfonate. Journal of applied toxicology.2016; 36(5):726-40.
5. Lu Li, Tong Li, Yuyu Zhang, Zongfu Pan, Bowen Wu, Xin Huang, Yihan Zhang,Yuqin Mei, Lijun Ge, Guofang Shen, Renshan Ge, Danyan Zhu, Yijia Lou*. Peroxisome proliferator-activated receptorβ/δ activation is essential for modulating p-Foxo1/Foxo1 status in functional insulin-positive cell differentiation. CELL DEATH DIS 2015; (6): e1715.
6. Limin Zhou, Bei Zheng, Leilei Tang, Yujie Huang, Danyan Zhu*, Involvement of PIKE in icariin induced cardiomyocyte differentiation from embryonic stem cells. Pharmazie, 2014; 69: 1-5.
7. Limin Zhou, Yujie Huang, Yingying Zhang, Qingwei Zhao, Bei Zheng, Yijia Lou, Danyan Zhu*. mGluR5 stimulating Homer-PIKE formation initiates icariin induced cardiomyogenesis of mouse embryonic stem cells by activating reactive oxygen species. Experimental Cell Research, 2013; 319: 1505-1514.
8. Danyan Zhu*, Limin Zhou, Yingying Zhang, Jiaqi Huang, Xing Pan, and Yijia Lou. Involvement of metabotropic glutamate receptor 5 in cardiomyocyte differentiation from mouse embryonic stem cells. Stem Cells and Development, 2012; 21(12): 2130-2141.
9. Danyan Zhu*, Rong Cui, Yingying Zhang, Huan Li, Limin Zhou, Yijia Lou. Involvement of Ubiquitin-Proteasome System in Icariin-Induced Cardiomyocyte Differentiation of Embryonic Stem Cells Using Two-Dimensional Gel Electrophoresis. Journal of Cellular Biochemistry, 2011; 112 (11): 3343-3353.
10. Danyan Zhu*, Jiaying Wu, Huan Li, Jieping Yan, Meiyuan Guo, Yanbo Wo, Yijia Lou. PPAR- Facilitating Maturation of Hepatic-Like Tissue Derived From Mouse Embryonic Stem Cells Accompanied by Mitochondriogenesis and Membrane Potential Retention. Journal of Cellular Biochemistry, 2010; 109(3): 498-508.
11. Danyin Wang, Yuzhe Hu, Sisi Kong, Yongping Yu, Danyan Zhu*, Yijia Lou*. Promoting effects of isobavachin on neurogenesis of mouse embryonic stem cells were associated with protein prenylation, Acta Pharmacologica Sinica, 2011; 32(4): 425-432.
12. Danyan Zhu, Yue Du, Xin Huang, Meiyuan Guo, Kuifen Ma, Yongping Yu, Yijia Lou*. MAPEG Expression in Mouse Embryonic Stem Cell-Derived Hepatic Tissue System. Stem Cells and Development, 2008; 17(4): 775-784.
13. Yanbo Wo, Danyan Zhu（并列第一作者）, Ying Hu , ZhiQiang Wang, Jian Liu, YiJia Lou*. Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiated cardiac differentiation of mouse embryonic stem cells. Journal of Cellular Biochemistry, 2008; 103: 1536-1550.
14. Danyan Zhu, Yijia Lou*. Icariin-mediated expressions of cardiac genes and modulation of nitric oxide signaling pathway during differentiation of mouse embryonic stem cells into cardiomyocytes in vitro. Acta Pharmacologica Sinica, 2006; 27(3): 311-320.
15. Danyan Zhu, Yijia Lou*. Inducible effects of icariin, icaritin and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro. Acta Pharmacologica Sinica, 2005; 26(4): 477-485.
16. Danyan Zhu, Linhai Qu, Xiangnan Zhang, Yijia Lou*. Icariin-mediated modulation of cell cycle and p53 during cardiomyocyte differentiation in embryonic stem cells. European Journal of Pharmacology, 2005; 514: 99-110.
17. Yanbo Wo, Danyan Zhu, Yijia Lou*. Involvement of NF-κB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem cells. European Journal of Pharmacology, 2008; 586(1-3): 59-66.
18. Ling Ding, Xingguang Liang, Ying Hu, Danyan Zhu, Yijia Lou*. Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro. Stem Cells and Development, 2008; 17(4): 751-760.
19. Ling Ding, Xingguang Liang, Danyan Zhu, Yijia Lou*. Peroxisome proliferator - activated receptor alpha is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro. Cell Biol Int, 2007; 31: 1002-1009.
20. Ling Ding, Xingguang Liang, Danyan Zhu, Yijia Lou*. Icariin promoted expression of PGC-1α, PPARα, and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro. Acta Pharmacologica Sinica, 2007; 28(10): 1541-1549.
21. Guofang Shen, Ying Hu, Jianwei Wu, Ke Jin, Danyan Zhu, Yandong Zhang, Yongping Yu, Yijia Lou*. A 2, 6-Disubstituted 4-Anilinoquinazoline Derivative Facilitates Cardiomyogenesis of Embryonic Stem Cells. ChemMedChem, 2012; 7(4): 733-740.
22. Xingguang Liang, Yuqin Mei, Xin Huang, Guofang Shen, Danyan Zhu, Yongping Yu, Jianan Wang*, Yijia Lou*. Junctophilin 2 knockdown interfere with mitochondrium status in ESC-CMs and cardiogenesis of ES cells. J Cell Biochem, 2012; 113: 2884-2894.
23. Zhiqiang Wang, Huanhuan Wang, Jiaying Wu, Danyan Zhu, Xiangnan Zhang, Lili Ou, Yongping Yu, Yijia lou*. Enhanced co-expression of β-tubulin Ⅲ and choline acetyltransferase in neurons from mouse embryonic stem cells promoted by icaritin in an estrogen receptor-independent manner. Chemico-Biological Interactions, 2009; 179(2-3): 375-385.
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