个人简介
1、学历背景 2000.9－2004.6年浙江大学药学院药物制剂专业理学学士 2004.9－2009.6 浙江大学药学院 药物化学医学博士
2、工作经历 2009.7 – 2011.6 浙江大学药学院博士后 2011.7至今浙江大学药学院讲师 2011.9至今香港大学化学系博士后
研究领域
1. 新型PKB/Akt抑制剂的设计、合成和抗肿瘤活性研究；
2. 类黄酮衍生物的设计合成及心血管保护活性研究。
近期论文
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X. Dong, J. Yan, D. Lu, P. Wu, J. Gao, T. Liu, B. Yang, Y. Hu, QSAR Models for isoindolinone-based p53-MDM2 Interaction Inhibitors Using Linear and Non-linear Statistical Methods. Chem. Bio. Drug. Des. 2012,79, 691-702.
X. Dong, X. Zhou, H. Jing, J. Chen, T. Liu, B. Yang, Q. He, Y. Hu, Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors. Eur. J. Med. Chem. 2011, 46, 5949-5958.
X. Dong, L. Wang, X. Huang, T. Liu, E. Wei, L. Du, B. Yang, Y. Hu, Pharmacophore Identification, Synthesis and Biological Evaluation of Carboxylated Chalcone Derivatives as CysLT1 Antagonists,Bioorg. Med. Chem.2010, 18, 5519-5527.
X. Dong, L. Du, Z. Pan, T. Liu, B. Yang, Y. Hu, Synthesis and biological evaluation of novel hybrid chalcone derivatives as vasorelaxant agents.Eur. J. Med. Chem. 2010, 45, 3986-3992.
X. Dong, T. Liu, J. Yan, P. Wu, J. Chen, Y. Hu, Synthesis, Biological Evaluation and Quantitative Structure-Activities Relationship of Flavonoids as Vasorelaxant Agents. Bioorg. Med. Chem.2009, 17, 716-726.
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