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2018
1. Donghong Zhao, Haofan Luo, Binhui Chen, Wenteng Chen, Guolin Zhang,* and Yongping Yu,* Palladium-Catalyzed H/D Exchange Reaction with 8-Aminoquinoline as the Directing Group: Access to ortho-Selective Deuterated Aromatic Acids and β-Selective Deuterated Aliphatic Acids. J. Org. Chem. 2018, accepted.
2. En Chen, Jiaan Shao, Pai Tang, Ke Shu, Wenteng Chen* and Yongping Yu*，Catalyst-free three-component sequencing approach for efficient assembly of [1, 3] oxazine N-fused imidazole-2-thiones. Green Chem. 2018, Accepted.
3. Xingyu Liu, Zhuang Nie, Jiaan Shao, Wenteng Chen,* Yongping Yu, * A Multi-component synthesis of N-substituted 2-amino-3-cyano pyrroles via ring-opening of nitroepoxides. New J. Chem. 2018, 42, 2368-2371.
2017
4. Jiaan Shao,* Richard A. Houghten, Colette T. Dooley, Margret Cazares, Jay P. McLaughlin, Shainnel O. Eans, Michelle L. Ganno, Michelle R. Hoot, Marc A. Giulianotti* and Yongping Yu*, A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation. Org. Biomol. Chem., 2017, 15, 7796-7801.
5. Wenteng Chen, Xingyu Liu, En Chen, Binhui Chen, Jiaan Shao*, Yongping Yu*, KI-mediated radical multi-functionalization of vinyl azides: a one-pot and efficient approach to β-keto sulfones and α-halo-β-keto sulfones. Org. Chem. Front., 2017, 4, 1162-1166.
6. Donghong Zhao, Yue Zhu, Shanshan Guo, Wenteng Chen, Guolin Zhang*, Yongping Yu*, A three-component one-pot synthesis of penta-substituted pyrroles via ring opening of α-nitroepoxides. Tetrahedron 2017, 73, 2872-2877.
7. Pai Tang, Can Zhang, Binhui Chen, Wenteng Chen,* Yongping Yu,* MnIII-catalyzed Phosphorylation of Vinyl Azides: The synthesis of ß-keto phosphine oxides. Tetrahedron Lett. 2017, 58, 2157-2161.
8. Shanshan Guo, Donghong Zhao, Yue, Zhu, Yongping Yu, Wenteng Chen,* Guolin Zhang,* One-pot three-component protocol for the synthesis of substituted 2-aminothiazoles. Synth. Commun.2017, 47, 1758-1764.
2016
9. Donghong Zhao, Shanshan Guo, Xiao Guo, Guolin Zhang *, Yongping Yu * Facile, efficient synthesis of polysubstituted thiazoles via anitroepoxides and thioureas. Tetrahedron 2016, 72, 5285-5289
10. Yuqin Mei, Zongfu Pan, Wenteng Chen, Minhua Xu, Danyan Zhu, Yongping Yu,* Yijia Lou*. A flavonoid compound promotes neuronal differentiation of embryonic stem cells via PPAR-β modulating mitochondrial energy metabolism. Plos One. 2016, 11, e0157747
11.Jiaan Shao, En Chen, Ke Shu, Wenteng Chen,* Guolin Zhang, Yongping Yu, * 6-Oxooxazolidine-quinazolines as noncovalent inhibitors with the potential to target mutant forms of EGFR. Bioorg. Med. Chem. 2016, 24, 3359-3370.
12. Ke Shu, Jiaan Shao, Hong Li, Binhui Chen, Pai Tang, Xingyu Liu, Wenteng Chen * and Yongping Yu,* Base-mediated synthesis of highly functionalized 2-aminonicotinonitriles from α-keto vinyl azides and α, α-dicyanoalkenes. RSC Adv., 2016, 6, 49123-49126.
2015
13. Binhui Chen, Shanshan Guo, Xiao Guo, Guolin Zhang,* Yongping Yu * Selective access to 4-substituted-2-aminothiazoles and 4-substituted-5-thiocyano-2-aminothiazoles from vinyl azides and potassium thiocyanate switched by palladium and iron catalysts. Org. Lett. 2015, 17, 4698.
14.Jiaan Shao, Xingyu Liu, Ke Shu, Pai Tang, Jing Luo, Wenteng Chen *and Yongping Yu*, Tuning the Annulation Reactivity of Vinyl Azides and carbazates: A divergent synthesis of aza-pyrimidinones and imidazoles. Org. Lett. 2015, 17, 4502.
15.Shanshan Guo, Binhui Chen, Xiao Guo, Guolin Zhang,* Yongping Yu*, Mn(II)-catalyzed synthesis of benzo[f]indole-4,9-diones via vinyl azides and 2- hydroxynaphthoquinone. Tetrahedron, 2015, 71, 9371.
16.Wei Huang, Shen Liu, Binhui Chen, Xiao Guo and Yongping Yu*, Synthesis of polysubstituted 4-aminopyrazoles and 4-hydroxypyrazoles from vinyl azides and hydrazines. RSC Adv. 2015, 5, 32740.
17.Jing Luo, Wenteng Chen, Jiaan Shao, Xingyu Liu, Ke Shu, Pai Tang and Yongping Yu*Synthesis of poly-functionalized imidazoles via vinyl azides annulation. RSC Adv. 2015, 5, 55808.
18. Xiao Guo, Jiaan Shao, HuanLiu, Binhui Chen, Wenteng Chen, Yongping Yu* Highly efficient and eco-friendly protocol to functionalized imidazoles via ring-opening of α-nitro epoxides. RSC Adv., 2015, 5, 51559.
19.Xiao Guo, Wenteng Chen, Binhui Chen, Wei Huang, Weixing Qi, Guolin Zhang* and Yongping Yu* One-pot three-component strategy for functionalized 2‑aminoimidazoles via ring opening of α-nitro epoxides. Org. Lett. 2015, 17, 1157.
20.Hangcheng Ni, Guolin Zhang* and Yongping Yu* Vinyl azides as versatile synthons for the synthesis of nitrogen-containing heterocycles. Curr. Org. Chem., 2015, 19, 2750.
21.Guolin Zhang,* Binhui Chen, Xiao Guo, Shanshan Guo, and Yongping Yu,* Iron (II)-promoted synthesis of 2-aminothiazoles via C-N bond formation from vinyl azides and potassium thiocyanate. Adv. Synth. Catal. 2015, 357, 1065.
22.Miao Hu, Marc A. Giulianotti, Jay P. McLaughlin, Jiaan Shao, Ginamarie Debevec, Laura E. Maida, Phaedra Geer, Margaret Cazares, Jaime Misler, Ling Li, Colette Dooley, Michelle L. Ganno, Shainnel O. Eans, Elisa Mizrachi, Radleigh G. Santos, Austin B. Yongye, Richard A. Houghten, * Yongping Yu* Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and d opioid receptor antagonist activities. Eur. J. Med. Chem. 2015, 92, 270.
2014
23.Guangxin Xia, Wenteng Chen, Jing Zhang, Jiaan Shao, Yong Zhang, Wei Huang, Leduo Zhang, Weixing Qi, Xing Sun, Bojun Li, Zhixiong Xiang, Chen Ma, Jia Xu, Hailin Deng, Yufeng Li, Ping Li, Hong Miao, Jiansheng Han, Yanjun Liu, Jingkang Shen,* and Yongping Yu* A chemical tuned strategy to develop novel irreversible EGFR-TK inhibitors with improved safety and pharmacokinetic profiles. J. Med. Chem. 2014, 57, 9889.
24.Shen Liu, Wenteng Chen, Jing Luo and Yongping Yu* [3+3] annulation of allylic phosphoryl-stabilized carbanions/phosphorus ylides and vinyl azides: a practice strategy for synthesis of polyfunctionalized anilines. Chem. Commun., 2014, 50, 8539.
25.Binhui Chen, Hangcheng Ni, Xiao Guo, Guolin Zhang* and Yongping Yu* Facile preparation of 3, 5-disubstituted-4-aminothiophene-2-carbaldehyde from a novel unexpected domino reaction of vinyl azides and 1, 4-dithiane-2, 5-diol. RSC Adv. 2014, 4, 44462.
26.Bo Tian, Tao, Jiang, Zhanying Shao, Zanjing Zhai, Haowei Li, Qiming Fan, Xuqiang Liu, Zhengxiao Ouyang, Tingting Tang, Qing Jiang, Minghao Zheng, Kerong Dai, An Qi,* Yongping Yu,* Zhenan Zhu,* The prevention of titanium-particle-induced osteolysis by OA-14 through the suppression of the p38 signaling pathway and inhibition of osteoclastogenesis. Biomaterials, 2014, 35, 8937-8950.
27.Tao Jiang, An Qin, ZhanYing Shao, Bo Tian, Zanjing Zhai, Haowei Li, Zhenan Zhu, Kerong Dai, Minghao Zheng, Yongping Yu, * Qing Jiang OA10 Is a Novel p38alpha Mitogen-Activated Protein Kinase Inhibitor That Suppresses Osteoclast Differentiation and Bone Resorption. J. Cell. Biochem. 2014, 115, 959.
28.Bo Tian, An Qin, Zhanying Shao, Tao Jiang, Zanjing Zhai, Haowei Li, Tingting Tang, Qing Jiang, Kerong. Dai, Minghao Zheng, Yongping Yu, * Zhenan Zhu, OA-4 Inhibits Osteoclast Formation and Bone Resorption via Suppressing RANKL Induced P38 Signaling Pathway. Curr. Med. Chem., 2014, 21, 641.
29.Shen Liu , Jiaan Shao , Xiao Guo , Jing Luo , Menghao Zhao , Guolin Zhang , Yongping Yu * Facile, efficient synthesis of polyfunctionalized 2-aminoimidazoles via vinyl azides and cyanamide. Tetrahedron, 2014, 70, 1418.
30.Jingfeng Ouyang, Wei Huang, Wanwan Yu, Wei Xiong, Ramanjaneya V.R. Mula, Hongbin Zou, Yongping Yu * Generation of insulin-producing cells from rat mesenchymal stem cells using an aminopyrrole derivative XW4.4. Chem-Biol Interact 2014, 208, 1.
2013
31. Jinhua Wu, Yaohong Zhang, Laura E. Maida, Radleigh G. Santos, Gregory S. Welmaker, Travis M. LaVoi, Adel Nefzi, Yongping Yu, Richard A. Houghten, Lawrence Toll,* and Marc A. Giulianotti*. Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies. J. Med. Chem. 2013, 56, 10103.
32. Yanli Cui, Zhaodong Cheng, Jianwei Mao, Yongping Yu, Regioselective 6-detrimethylsilylation of per-O-TMS-protected carbohydrates in the presence of ammonium acetate. Tetrahedron Lett. 2013, 54, 3831.
33.Jianwei Wu, Wenteng Chen, Guangxin Xia, Jing Zhang, Jiaan Shao, Biqin Tan, Chunchun Zhang, Wanwan Yu, Qinjie Weng, Haiyan Liu, Miao Hu, Hailin Deng, Yu Hao, Jingkang Shen,* and Yongping Yu* Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting EGFR. ACS Med. Chem. Lett., 2013, 4, 974.
34.Miao Hu, Wei Huang, Marc A. Giulianotti, Richard A. Houghten and Yongping Yu* Parallel Synthesis of 1, 6-disubstituted-1, 2, 4-triazin-3-ones on solid-phase. ACS Comb. Sci. 2013, 15, 335.
35.Jun Chen, Wenteng Chen, Yongping Yu * and Guolin Zhang * One-pot synthesis of disubstituted imidazole derivatives from a-azido ketones catalyzed by potassium ethylxanthate. Tetrahedron Lett. 2013, 54, 1572.
36.Jun Chen, Hangcheng Ni, Wenteng Chen, Guolin Zhang * and Yongping Yu * A new strategy for facile synthesis of tetrasubstituted pyridine derivatives. Tetrahedron 2013, 69, 8069.
37.Guolin Zhang,* Hangcheng Ni, Wenteng Chen, Jiaan Shao, Huan Liu, Binhui Chen and Yongping Yu* One-pot three-component approach to the synthesis of polyfunctional pyrazoles. Org. Lett. 2013, 15, 5967.
38.Li Wang, Wenteng Chen, Zhanying Shao, Shen Liu and Yongping Yu* Selective halogenation of arylurea derivatives by Pd-catalyzed C-H activation. Curr. Org. Chem., 2013, 17, 3092.
39. Wenteng Chen, Jiaan Shao, Miao Hu, Wanwan Yu, Marc A. Giulianotti, Richard A. Houghten* and Yongping Yu* A traceless approach to amide and peptide construction from thioacids and dithiocarbamate-terminal amines Chem.Sci. 2013, 4, 970.
40.Ginamarie Debevec, Wenteng Chen, Yongping Yu, Richard A. Houghten , Marc A. Giulianotti * Libraries from libraries: a series of sulfonamide linked heterocycles derived from the same scaffold. Tetrahedron Letters, 2013, 54, 4296.
41.Wanwan Yu, Wenteng Chen, Shen Liu, Jiaan Shao, Zhanying Shao, Yongping Yu* Facile, eco-friendly, catalyst-free synthesis of polyfunctionalized 2-aminopyrroles. Tetrahedron, 2013, 69 1953.
42. Yaohong Zhang, Shen Liu, Wanwan Yu, Miao Hu, Guolin Zhang, Yongping Yu* Palladium-catalyzed synthesis of 3-alkenyl indoles from 2-azido-3-arylacrylates and terminal alkenes at room temperature. Tetrahedron 2013, 69, 2070.
2012
43. Marc A. Giulianotti, Gina Debevec, RG Santos, Laura E. Maida, Wenteng Chen, Lili Ou, Yongping Yu, CT Dooley, Richard A. Houghten A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries. ACS Comb. Sci., 2012, 14, 503.
44. Jiaying Wu, Zongfu Pan, Zhiqiang Wang, Wenjie Zhu, Yuanyuan Shen, Rong Cui, Jiazhen Lin, Hao Yu, Qiongque Wang, Jianchang Qian, Yongping Yu, Danyan Zhu, Yijia Lou, Ginsenoside Rg1 protection against β-amyloid peptide-induced neuronal apoptosis via estrogen receptor α and glucocorticoid receptor-dependent anti-protein nitration pathway. Neuropharmacology 2012, 63, 349.
45.Xingguang Liang, Yuqin Mei, Xin Huang, Guofang Shen, Danyan Zhu, Yongping Yu, Jianan Wang,* Yijia Lou.* Junctophilin 2 knockdown interfere with mitochondrium status in ESC-CMs and cardiogenesis of ES cells. J Cell Biochem. 2012, 113, 2884.
46. Jiaying Wu, Zongfu Pan, Zhiqiang Wang, Wenjie Zhu, Yuanyuan Shen, Rong Cui, Jiazhen Lin, Hao Yu, Qiongque Wang, Jianchang Qian, Yongping Yu, Danyan Zhu, * Yijia Lou * Ginsenoside Rg1 protection against β-amyloid peptide-induced neuronal apoptosis via estrogen receptor α and glucocorticoid receptor-dependent anti-protein nitration pathway. Neuropharmacology, 2012, 63, 349.
47. Yanli Cui*, Minghan Xu, Jianwei Maob, Jingfeng Ouyang, Rongzhen Xu, Yongping Yu, Synthesis of berbamine acetyl glycosides and evaluation of antitumor activity. Eur. J. Med. Chem. 2012, 54, 867.
48.Guofang Shen, Ying Hu, Jianwei Wu, Ke Jin, Danyan Zhu, Yandong Zhang, Yongping Yu,* and Yijia Lou*. A 2, 6-disubstituted 4-anilinoquinazoline derivative facilitates cardiomyogenesis of embryonic stem cells. ChemMedChem, 2012, 7, 733.
49.Jiaan Shao, Wanwan Yu, Zhanying Shao, Yongping Yu*, A “one-pot” multicomponent approach to polysubstituted 4-aminopyridines, Chem. Commun., 2012, 48, 2785.
50. Zhanying Shao, Qinghai Pan, Jun Chen, Yongping Yu*, Guolin Zhang*, Synthesis of polysubstituted 5-aminopyrimidine-2(1H)-thiones from vinyl azides and thiourea, Tetrahedron, 2012, 68, 6565.
51.Fangli Qiu, Jianwei Wu, Yaohong Zhang, Miao Hu, Yongping Yu*, One-pot cascade approach to 1,3´-bipyrrole derivatives from trisubstituted olefins with tosylmethyl-isocyanide (TosMIC), Tetrahedron Lett., 2012, 53, 446.
52.Jingfeng Ouyang, Jiaan Shao, Hongbin Zou, Yijia Lou, Yongping Yu*, Hepatic differentiation of rat mesenchymal stem cells by a small molecule, ChemMedChem, 2012, 7, 1447.
53. Wenteng Chen, Jiaan Shao, Zhi Li, Giulianotti MA, Yongping Yu*, Synthesis of 2,3,4- trisubstituted pyrroles via a facile reaction of vinyl azides and tosylmethyl isocyanide, Can. J. Chem. 2012, 90, 214.
54. Fangli Qiu, Jianwei Wu, Yaohong Zhang, Miao Hu, Feng Yu, Guolin Zhang, Yongping Yu*, A novel synthesis of multisubstituted pyrroles via trisubstiuted olefins and TosMIC derivatives, Lett. Org. Chem. 2012, 9, 305.
55. Joshua J. Ziarek, Yan Liu, Emmanuel Smith, Guolin Zhang, Francis C. Peterson, Jun Chen, Yongping Yu, Yu Chen, Brian F. Volkman, and Rongshi Li.* Fragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction. Curr Top Med Chem. 2012, 12, 2727.
2011
56. Li Wang, Shen Liu, Zhi Li, Yongping Yu*, Palladium-catalyzed direct olefination of urea derivatives with n-butyl acrylate by C-H bond activation under mild reaction conditions, Org. Lett, 2011, 13, 6137.
57.Miao Hu, Jianwei Wu, Yaohong Zhang, Fangli Qiu, Yongping Yu*, Synthesis of polysubstituted 5-aminopyrimidines from α-azidovinyl ketones and amidines, Tetrahedron, 2011, 67, 2676.
58.Lili Ou, Jiaan Shao, Guolin Zhang*, Yongping Yu*; Metal-free carbon–nitrogen bond-forming coupling reaction between arylboronic acids and organic azides, Tetrahedron Lett. 2011, 52, 1430.
59.Wenteng Chen, Zhi Li, Lili Ou, Giulianott MA, Houghten RA, Yongping Yu*, Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization, Tetrahedron Lett. 2011, 52, 1456.
60. Hongbin Zou, Liang Zhang, Jingfeng Ouyang, Giulianott MA, Yongping Yu*, Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents, Eur. J. Med. Chem. 2011, 46, 5970.
61. Hongbin Zou, Huajian Zhu, Jiaan Shao, Jianwei Wu, Wenteng Chen, Marc A. Giulianotti, Yongping Yu* A facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and vinyl azides Tetrahedron 2011, 67,4887.
62.Hongbin Zou, Liang Zhang, Leixiang Yang, Liuqing Yang, Yu Zhao, Yongping Yu, Joachim Stöckigt* Nat. Prod. Res., 2011, 25, 203-221.
63.Huajian Zhu, Joachim Stöckigt, Yongping Yu, and Hongbin Zou*“One-Pot” Multicomponent Approach to Indolizines and Pyrido[1,2-a]indoles Org. Lett. 2011, 13, 2792–2794.
64.Lili Ou, Zhanying Shao, Wenteng Chen, Giulianotti MA, Houghten RA, Yongping Yu*, Solid-Phase Synthesis of 2,3,5,6-Tetrahydro-1H-imidazo[1,2-a]benzo[d]-[1,3] diazepines via Pd(OAc)2/Cu(OAc)2-Cocatalyzed Cyclization, Synlett, 2011, 15, 2259-2261
65.Jue Zhou*, Fan Qu, Yongping Yu, Chemical and Ecological Evaluation of a Genuine Chinese Medicine: Atractylodes Macrocephala Koidz, Afr. J. Tradit. Complem. 2011, 8, 405-411
66.Lili Ou, Shuang Han, Wenbo Ding, Ping Jia, Bo Yang, Medina-Franco JL, Giulianotti MA, Jian-zhong Chen, Yongping Yu*, Parallel synthesis of novel antitumor agents: 1,2,3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR, Mol Divers, 2011, 15, 927-946
67.Lili Ou, Shuang Han, Wenbo Ding, Zhe Chen, Ziqi Ye, Hongyu Yang, Guolin Zhang, Yijia Lou, Jian-zhong Chen, Yongping Yu*, Design, synthesis and 3D-QSAR study of cytotoxic flavonoid derivatives, Mol Divers. 2011, 15, 665-675.
68.Zhe Chen, Xin Huang, Hongyu Yang, Wenbo Ding, Lingyan Gao, Ziqi Ye, Yandong Zhang, Yongping Yu,∗, Yijia Lou,∗ Anti-tumor effects of B-2, a novel 2,3-disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazoline derivative, on the human lung adenocarcinoma A549 cell line in vitro and in vivo. Chemico-Biological Interactions, 2011, 189, 90-99.
2010
69. Wenteng Chen, Miao Hu, Jianwei Wu, Hongbin Zou, Yongping Yu*. Domino Approach for the Synthesis of Pyrrolo[1,2-]pyrazine from Vinyl Azides. Org. Lett., 2010, 12, 3863–3865.
70.Hongbin Zou, Hao Wu, Xiangnan Zhang, Yu Zhao, Joachim Stöckigt, Yijia Lou, Yongping Yu*. Synthesis, biological evaluation, and structure–activity relationship study of novel cytotoxic aza-caffeic acid derivatives. Bioorg. Med. Chem., 2010, 18, 6351–6359.
71.Hongbin Zou, Huajian Zhu, Liang Zhang, Liuqing Yang, Yongping Yu* and Joachim Stöckigt. *A Facile Chemoenzymatic Approach: One-Step Syntheses of Monoterpenoid Indole Alkaloids. Chem.–an Asian J., 2010, 5, 2400–2404.
72. Ting Ma, Wenteng Chen, Guolin Zhang and Yongping Yu*.Synthesis and Antitumor Evaluation of a Novel Class of 4-Substituted-1, 4-Dihydroisoquinolin-3-ones J. Comb. Chem., 2010, 12, 488–490.
73.Jianwei Wu; Wenteng Chen; Miao Hu; Hongbin Zou; Yongping Yu*. Synthesis of polysubstituted 5-aminooxazoles from α-diazocarbonyl esters and α-isocyanoacetamides. Org. Lett., 2010, 12, 616–618.
74.Ziqi Ye, Zhe Chen, Wenteng Chen, Jinwen Xie, Hongyu Yang, Yijia Lou*, Yongping Yu*. XJW20, a novel oxoindole derivative, induces G2/M arrest and apoptosis selectively in K562 leukemia cell line. Chem.-Biol. Interact., 2010, 183, 133–141.
75.Zhang Hu, Wei Ye, Hongbin Zou, Yongping Yu*. 2, 2’-Biimidazole as an Efficient Ligand for Copper (I)-Catalyzed C-N Coupling Reactions. Synth. Commun., 2010, 40(2), 222-228.
76.Chao Yao; Yandong Zhang; Guolin Zhang; Wenteng Chen; Richard A Houghten. Yongping Yu*; Traceless Approach for the Synthesis of 3, 5-Disubstituted Thiohydantoins on Functionalized Ionic-Liquid Support. Synth. Commun., 2010, 40, 717–724.
77.Yanli Cui; Caixia Wang; Jianwei Mao; Yongping Yu*. A facile and practical approach to randomly methylated β-cyclodextrin. J. Chem. Tech. Biotech., 2010, 85, 248–251.
2009
78.Jinwen Xie, Ting Ma, Ying Gu, Xuzhao Zhang, Xi Qiu, Lei Zhang, Rongzhen Xu, Yongping Yu*. Berbamine derivatives: A novel class of compounds for anti-leukemia activity. Eur. J. Med. Chem., 2009, 44, 3293–3298.
79.Yandong Zhang, Zhe Chen, Yijia Lou, Yongping Yu*. 2, 3-Disubstituted 8-arylamino-3H-imidazo [4, 5-g]quinazolines: a novel class of antitumor agents. Eur. J. Med. Chem., 2009, 44, 448–452.
80. Zhang Hu, Ting Ma, Zhe Chen, Ziqi Ye, Guolin Zhang, Yijia Lou, Yongping Yu*. Solid-phase synthesis and antitumor evaluation of 2, 4-diamino-6-aryl-1, 3, 5-triazines. J. Comb. Chem., 2009, 11, 267–273.
81.Yangmei Li, Yongping Yu*, Marc Giulianotti, Richard A. Houghten. One-pot high-throughput synthesis of β-turn cyclic peptidomimetics via "volatilizable" supports. J. Org. Chem., 2009, 74, 2183–2185.
82.Zhiqiang Wang, Huanhuan Wang, Jiaying Wu, Danyan Zhu, Xiangnan Zhang, Lili Ou, Yongping Yu, Yijia.Lou*. Enhanced co-expression of beta-tubulin III and choline acetyltransferase in neurons from mouse embryonic stem cells promoted by icaritin in an estrogen receptor-independent manner. Chem.-Bio. Interact.. 2009, 179, 375–385.
83.Yangmei, Li, Austin Yongye, Marc Giulianotti, Karina Martinez-Mayorga, Yongping Yu, Richard A. Houghten*. Synthesis of cyclic peptides through direct aminolysis of peptide thioesters catalyzed by imidazole in aqueous organic solutions. J. Comb. Chem., 2009, 11, 1066–1072.
84.Austin B. Yongye, Yangmei Li, Marc A. Giulianotti, Yongping Yu, Richard A. Houghten*, Karina, Martinez-Mayorga. Modeling of peptides containing D-amino acids: implications on cyclization. J. Comp.-Aided Mol. Des., 2009, 23, 677–689.
85.Jose L. Medina-Franco*, Marc A. Giulianotti, Yongping Yu, Liangliang Shen, Libo Yao, Narender Singh. Discovery of a novel protein kinase B inhibitor by structure-based virtual screening. Bioorg. Med. Chem. Lett., 2009, 19, 4634–4638.
86. Ping Jia, Xuling Wu, Yongping Yu, Guolin Zhang*. An efficient one-pot synthesis of 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione from 9-bromo-11-hydroxypregna-1, 4, 16- triene-3, 20-dione by two annulation reactions. Steroids, 2009, 74, 229–232.
2008
87. Yandong, Zhang, Chao Yao, Richard A. Houghten, Yongping Yu*. Solid-phase Synthesis of 4, 8-Disubstituted-8, 9-dihydropyrazino [2, 3-g] quinazolin-7(6H)-ones. Biopolymer (Peptide Science), 2008, 90, 439–443.
88.Yangmei Li, Yongping Yu, Marc Giulianotti, Richard A. Houghten*. High Throughput Synthesis of Peptide a-Thioesters Through the Use of “Volatilizable” Support. J. Comb. Chem., 2008, 10, 613–616.
89.Yangmei Li, Yongping Yu*, Marc Giulianotti, Richard A. Houghten. High-throughput parallel synthesis of 3, 4-disubstituted 1-(x-hydroxyalkyl) imidazolin-2-ones on ‘volatilizable’ supports. Tetrahedron Lett., 2008, 49, 3632–3633.
90.Yanbo Wo; Danyan Zhu; Yongping Yu; Yijia Lou*. Involvement of NF-κB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem cells. Eur. J. Pharm., 2008, 586, 59–66.
2007
91.Jinwen Xie; Jing Sun; Guolin Zhang; Richard A. Houghten; Yongping Yu*. A traceless approach for the solid-phase parallel synthesis of trisubstituted oxindoles. J. Comb. Chem., 2007, 9, 566–568.
92. Yandong Zhang; Chuanlian Xu; Richard A Houghten.; Yongping Yu*. Scaffold Approach for Solid-Phase Synthesis of 2, 3-Disubstituted 8-Arylamino-3H-imidazo [4, 5-g]quinazolines. J. Comb. Chem., 2007, 9, 9–11.
93.Yandong Zhang; Qiaosheng Zhou; Richard A Houghten.; Yongping Yu*. Solid-phase synthesis of 3-alkyl-8-arylamino-1H-imidazo [4, 5-g] quinazolin-2(3H)-thiones and 3-alkyl-8-arylamino-1H- imidazo [4, 5-g] quinazolin-2(3H)-ones. Tetrahedron Lett., 2007, 48, 7042–7045.
Before 2007
94.Richard A. Houghten*, Yongping Yu*. “Volatilizable” Supports For High-throughput Organic Synthesis. J. Am. Chem. Soc., 2005, 127, 8582–8583.
95.Yongping Yu, John M. Ostresh, Richard A. Houghten. “A Traceless Approach for the Solid Phase Synthesis of Substituted 6-Amino-1, 3, 5-triazine-2, 4-diones”. J. Comb. Chem., 2004, 6, 83.
96.G. Zhong, Yongping Yu. “Enantioselective Synthesis of Allylic Alcohols by the Sequential Aminoxylation-Olefination Reactions of Aldehydes under Ambient Conditions.” Org. Lett., 2004, 6, 1637
97.A. Nefzi, John M. Ostresh., Yongping Yu, Richard A. Houghten. Combinatorial Chemistry: Libraries from Libraries, the Art of the Diversity-Oriented Transformation of Resin-Bound Peptides and Chiral Polyamides to Low Molecular Weight Acyclic and Heterocyclic Compounds. J.Org. Chem. 2004, 69, 3603.
98.Yongping Yu, John M. Ostresh, Richard A. Houghten. “The Combined Solid / Solution-Phase Synthesis of Nitrosamines: The Evolution of the ‘Libraries from Libraries’ Concept.” J. Org. Chem., 2003, 68, 183.
99.Yongping Yu, John M. Ostresh, Richard A. Houghten. “Solid Phase Synthesis of Indolines via Palladium-Catalyzed Cyclization.” Tetrahedron Lett., 2003, 44, 2569.
100.Yongping Yu, John M. Ostresh, Richard A. Houghten. “Solid Phase Synthesis of 3-amino-1,2,4-triazoles.” Tetrahedron Lett., 2003, 44, 7841.
101.Yongping Yu, John M. Ostresh, Richard A. Houghten. “The Combined Solid and Solution-Phase Synthesis of Small Molecular Libraries: The Evolution of “Libraries from Libraries” Concept.” In Peptide Revolution: Genomics, Proteomics & Therapeutics, Proceedings of the 18th American Peptide Symposium. American Peptide Society, 2003.
102.Yongping Yu, John M. Ostresh, Richard A. Houghten. Efficient Solid-Phase Synthesis of 1, 3, 5,-Trisubstituted-2,4,6-Trione Derivatives. J.Comb.Chem.2002, 4, 484.
103.Yongping Yu, John M. Ostresh, Richard A. Houghten. A Traceless Approach for the Parallel Solid Phase Synthesis of 2-(Arylamino)quinazolinones. J.Org.Chem, 2002, 67, 5831.
104.Yongping Yu, John M. Ostresh, Richard A. Houghten. Solid-Phase Synthesis of 1, 5-Disubstituted-2-Arylimidazolones. J. Org. Chem. 2002, 67, 3138.
105. Yongping Yu, John M. Ostresh, Richard A. Houghten. Solid-Phase Parallel Synthesis of 2-aminoimidazolidin-4-ones. Tetrahedron, 2002, 58, 3349.
106. Yongping Yu, John M. Ostresh, Richard A. Houghten. Solid-Phase Synthesis of 2, 3, 5- Trisubstituted 4H-Imidazolones. J.Comb. Chem., 2001, 3, 521.
107.Yongping Yu, John M. Ostresh, Richard A. Houghten. Solid-Phase Synthesis of 1, 7-Disubstituted-1, 3, 5-triazepane-2,4-diones. Org. Lett., 2001, 3, 2797.
108. Yongping Yu, John M. Ostresh, Richard A. Houghten. Solid-Phase Synthesis of [3, 5, 7]- 1H-imidazo[1,5-α]imidazol-2(3H)-ones. Tetrahedron Lett. 2001, 42, 623.
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