个人简介
A.B. Chemistry, Harvard University (1981)
Ph.D. Chemistry, Columbia University (1986)
Post-Doctoral Fellow, California Institute of Technology (1986-7)
近期论文
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“Backbone modification of a polypeptide drug alters duration of action in vivo.” Cheloha RW, Maeda A, Dean T, Gardella TJ, Gellman SH. Nat Biotechnol. 2014 ,32, 653.
“Hydrophobicity and Helicity Regulate the Antifungal Activity of 14-Helical β-Peptides.” Lee MR, Raman N, Gellman SH, Lynn DM, Palecek SP. ACS Chem Biol. 2014,9, 1613.
“Building Proficient Enzymes with Foldamer Prostheses.” Mayer C, Müller MM, Gellman SH, Hilvert D. Angew Chem Int Ed Engl. 2014, 53, 6978.
“Two interdependent mechanisms of antimicrobial activity allow for efficient killing in nylon-3-based polymeric mimics of innate immunity peptides.” Lee M, Chakraborty S, Schmidt NW, Murgai R, Gellman SH, Wong GC. Biochim Biophys Acta. 2014, ASAP.
“Improved Glucose-Neopentyl Glycol (GNG) Amphiphiles for Membrane Protein Solubilization and Stabilization.” Cho KH, Bae HE, Das M, Gellman SH, Chae PS.Chem Asian J. 2014, 9, 632.
“Mimicking the First Turn of an α-Helix with an Unnatural Backbone: Conformation-Specific IR and UV Spectroscopy of Cyclically Constrained β/γ-Peptides.” Gord JR, Walsh PS, Fisher BF, Gellman SH, Zwier TS. J Phys Chem B. 2014, ASAP.
“Structure–Activity Relationships among Antifungal Nylon-3 Polymers: Identification of Materials Active against Drug-Resistant Strains of Candida albicans." Liu R, Chen X, Falk SP, Mowery BP, Karlsson AJ, Weisblum B, Palecek SP, Masters KS, Gellman SH., J Am Chem Soc. 2014, 136, 4333.
“Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern." Liu R, Chen X, Chakraborty S, Lemke JJ, Hayouka Z, Chow C, Welch RA, Weisblum B, Masters KS, Gellman SH., J Am Chem Soc. 2014, 136, 4410.
“Hydrophobic variants of ganglio-tripod amphiphiles for membrane protein manipulation”Chae PS, Cho KH, Wander MJ, Bae HE, Gellman SH, Laible PD, Biochim Biophys Acta.2014, 1838, 278.
“Two-dimensional sum-frequency generation reveals structure and dynamics of a surface-bound Peptide.” Laaser JE, Skoff DR, Ho JJ, Joo Y, Serrano AL, Steinkruger JD, Gopalan P, Gellman SH, Zanni MT. J Am Chem Soc. 2014, 136, 956.
“Hydrophobic Variations of N-Oxide Amphiphiles for Membrane Protein Manipulation: Importance of Non-hydrocarbon Groups in the Hydrophobic Portion.” Chae PS, Sadaf A, Gellman SH., Chem Asian J. 2014, 9, 110.
“Evidence for small-molecule-mediated loop stabilization in the structure of the isolated Pin1 WW domain.” Mortenson DE, Kreitler DF, Yun HG, Gellman SH, Forest KT. Acta Crystallogr D Biol Crystallogr. 2013, 2506.
“Evaluation of a Cyclopentane-Based γ-Amino Acid for the Ability to Promote α/γ-Peptide Secondary Structure.” Giuliano MW, Maynard SJ, Almeida AM, Reidenbach AG, Guo L, Ulrich EC, Guzei IA, Gellman SH. J Org Chem. 2013, 78, 12351.
“Improved Glucose-Neopentyl Glycol (GNG) Amphiphiles for Membrane Protein Solubilization and Stabilization.” Cho KH, Bae HE, Das M, Gellman SH, Chae PS. Chem Asian J. 2013, ASAP.
“Nylon-3 Polymers That Enable Selective Culture of Endothelial Cells.” Liu R, Chen X, Gellman SH, Masters KS. J Am Chem Soc. 2013, 135, 16296.
“Cyclic Constraints on Conformational Flexibility in γ-Peptides: Conformation Specific IR and UV Spectroscopy.” Walsh PS, Kusaka R, Buchanan EG, James WH 3rd, Fisher BF, Gellman SH, Zwier TS. J Phys Chem A. 2013, 117, 12350.
“Novel Tripod Amphiphiles for Membrane Protein Analysis.” Chae PS, Kruse AC, Gotfryd K, Rana RR, Cho KH, Rasmussen SG, Bae HE, Chandra R, Gether U, Guan L, Kobilka BK, Loland CJ, Byrne B, Gellman SH. Chemistry. 2013, ASAP.
“Hydrophobic variants of ganglio-tripod amphiphiles for membrane protein manipulation.” Chae PS, Cho KH, Wander MJ, Bae HE, Gellman SH, Laible PD. Biochim Biophys Acta.2013, 1838, 278.
“Evidence for Phenylalanine Zipper-Mediated Dimerization in the X-ray Crystal Structure of a Magainin 2 Analogue" Hayouka Z, Mortenson DE, Kreitler DF, Weisblum B, Forest KT,Gellman SH, J Am Chem Soc. 2013, ASAP.
“Role of Ring-Constrained γ-amino Acid Residues in α/γ-peptide Folding: Single-Conformation UV and IR Spectroscopy” Kusaka R, Zhang D, Walsh PS, Gord JR, Fisher BF, Gellman SH, Zwier TS. J Phys Chem A. 2013, ASAP.