Bentley, William E. - University of Maryland - Chemical and Biomolecular Engineering

个人简介

Ph.D., University of Colorado at Boulder, 1989 William E. Bentley is the Robert E. Fischell Distinguished Professor of Engineering and founding Chair of the Fischell Department of Bioengineering. He is also appointed to the Department of Chemical and Biomolecular Engineering at the University of Maryland, College Park and the Institute for Bioscience and Biotechnology Research. At Maryland since 1989, Dr. Bentley has focused his research on the development of molecular tools that facilitate the expression of biologically active proteins, having authored over 250 related archival publications. Recent interests are on deciphering and manipulating signal transduction pathways, including those of bacterial communication networks, for altering cell phenotype. To enable discovery, his lab develops new strategies for opening ‘communication’ between devices and biological systems by the creation and facile assembly of biologically functional interfaces. These concepts are emerging as a field of ‘biofabrication’ that exploits biological components and processes for assembly. He has served on advisory committees for the NIH, NSF, DOD, DOE, FDA, USDA, and several state agencies. He has mentored more than 30 PhDs and 15 postdocs, many now in leadership roles within industry (18), federal agencies (4) and academia (22). He co-founded a protein manufacturing company, Chesapeake PERL, based on insect larvae as mini bioreactors. Dr. Bentley was recipient of the SIM’s Schering-Plough Young Investigator Award, the Charles Thom Award of the SIMB, and the AIChE’s FPB Division Award. He is also a Fellow of the ACS, AAAS, and AIMBE and is an elected member of the American Academy of Microbiology.

研究领域

solution blow spun functional polymers as surgical sealants; biosensors that change color upon detection of pathogens; point-of-care diagnostics for urea cycle disorder metabolites; solid, non-flammable, polymer electrolytes for lithium ion batteries; functional magnetodielectric polymer nanocomposites for flexible antennas.

近期论文

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Terrell J.L., Wu H.C., Tsao C.Y., Barber N.B., Servinsky M.D., Payne G.F., and Bentley W.E. (2015) Nano-guided cell networks as conveyors of molecular communication, Nature Communications, doi: 10.1038/ncomms9500. Payne, G.F., Kim, E., Cheng, Y., Wu, H-C., Ghodssi, R., Rubloff, G.W., Raghavan, S.R., Culver, J.N, and W.E. Bentley (2013) Accessing Biology’s Toolbox for the Mesoscale Biofabrication of Soft Matter, Soft Matter, doi:10.1039/c3sm50527h. Bacalocostantis, I., Mane, V.P., Goodley, A.S., Bentley, W.E., Muro, S., and P. Kofinas (2013) Investigating Polymer Thiolation in Gene Delivery, J. Biomaterials Science and Polymer Ed, 24(8):912-926. Betz, J.F., Cheng, Y., Tsao, C.-Y., Zargar, A., Luo, X, Payne, G.F., Bentley, W.E., and G.W. Rubloff (2013) Optically Clear Alginate Hydrogels for Spatially Controlled Cell Entrapment and Culture at Microfluidic Electrode Surfaces. Lab on a Chip, 13(10): 1854-1858. Kim, E., Gordonov, T., Bentley, W. E., and G.F. Payne (2013) Amplified and in situ detection of redox-active metabolite using a biobased redox capacitor, Analytical Chemistry 85, 2102-2108. Kim, E., Gordonov, T., Liu, Y., Bentley, W. E., and G. F. Payne (2013) Reverse engineering to suggest biologically relevant redox activities of phenolic materials, ACS Chemical Biology 8, 716-724. Liba, B. D., Kim, E., Martin, A. N., Liu, Y., Bentley, W. E., and G.F. Payne (2013) Biofabricated film with enzymatic and redox-capacitor functionalities to harvest and store electrons, Biofabrication 5, 015008. Liu, Y., B. Zhang, K. M. Gray, Y. Cheng, E. Kim, G. W. Rubloff, W. E. Bentley, Q. Wang, G. F. Payne (2013) Electrodeposition of a Weak Polyelectrolyte Hydrogel: Remarkable Effects of Salt on Kinetics, Structure and Properties. Soft Matter, 9; 2703-2710. Gupta, A., Terrell, J.L., Fernandes, R., Dowling, M.B., Payne, G.F., Raghavan, S.R., and W.E. Bentley (2013) Encapsulated Fusion Protein Confers “Sense and Respond” Activity to Chitosan-Alginate Capsules to Manipulate Bacterial Quorum Sensing. Biotechnology and Bioengineering, 110, 552-562. Payne, G.F., E. Kim, Y. Cheng, H-C. Wu, R. Ghodssi, G.W. Rubloff, S.R. Raghavan, J.N. Culver, and W.E. Bentley. (2013) Accessing Biology's Toolbox for the Mesoscale Biofabrication of Soft Matter. Soft Matter, 9, 6019-6032. Wu, H.-C., Hebert, C.G., Hung, C.-W., Quan, D.N., Carter, K.K., and W.E. Bentley (2013) Tuning Cell Cycle of Insect Cells for Enhanced Protein Production. Journal of Biotechnology, 10.1016/j.biotec.2013.08.017. Wu, H. C., Tsao, C. Y., Quan, D. N., Cheng, Y., Servinsky, M. D., Carter, K. K., Jee, K. J., Terrell, J. L., Zargar, A., Rubloff, G. W., Payne, G. F., Valdes, J. J., and W.E. Bentley (2013) Autonomous bacterial localization and gene expression based on nearby cell receptor density, Molecular Systems Biology 9, 636. Bentley, W.E., and G.F. Payne (2013) Nature’s Other Self-Assemblers, Science, 341(6142): 136-137. Carter, K.K., Valdes, J.J., and W.E. Bentley (2012) Pathway Engineering via Quorum Sensing and sRNA Riboregulators – Interconnected Networks and Controllers, Metabolic Engineering, 14(3): 281-288. Terrell, J.L., Gordonov, T., Cheng, Y., Wu, H.C., Sampey, D., Luo, X., Tsao, C.Y., Ghodssi, R., Rubloff, G.W., Payne, G.F., and W.E. Bentley (2012) Integrated Biofabrication for Electro-Addressed In-Film Bioprocessing, Biotechnology Journal, 7(3):428-439. Cheng, Y., Tsao, C.-Y., Wu, H.-C., Luo, X.L., Terrell, J.L., Betz, J., Payne, G.F., Bentley, W.E., and G.W. Rubloff (2012) Electroaddressing Functionalized Polysaccharides as Model Biofilms for Interrogating Cell Signaling, Advanced Functional Materials, 22(3):519-528. Liu, Y., Terrell, J.L., Tsao, C.-Y., Wu, H.C., Jawaji, V., Kim, E., Cheng, Y., Wang, Y.F., Ulijn, R.V., Raghavan, S.R., Rubloff, G.W., Bentley, W.E., and G.F. Payne (2012) Biofabricating Multifunctional Soft Matter with Enzymes and Stimuli-Responsive Materials, Advanced Functional Materials, 22(14):3004-3012. Luo, X.L., Wu, H.C., Tsao, C.-Y., Cheng, Y., Betz, J., Payne, G.F., Rubloff, G.W., and W.E. Bentley (2012) Biofabrication of Stratified Biofilm Mimics for Observation and Control of Bacterial Signaling, Biomaterials, 33(20): 5136-5143. Gamby, S., Roy, V., Guo, M., Smith, J.A.I., Wang, J.X., Stewart, J.E., Wang, X., Bentley, W.E., and H.O. Sintim (2012) Altering the Communication Networks of Multispecies Microbial Systems Using a Diverse Toolbox of AI-2 Analogues, ACS Chemical Biology, 7(6):1023-1030. Kim, E., Liu, Y., Bentley, W.E., and G.F. Payne (2012) Redox Capacitor to Establish Bio-Device Redox-Connectivity, Advanced Functional Materials, 22(7):1409-1416. Gray, K. M., B. D. Liba, Y. Wang, Y. Cheng, G. W. Rubloff, W. E. Bentley, A. Montembault, I. Royaud, L. David, G. F. Payne (2012) Electrodeposition of a Biopolymeric Hydrogel: Potential for One-step Protein Electroaddressing. Biomacromolecules, 13(4), 1181-1189. Gordonov, T., Liba, B., Terrell, J.L., Cheng, Y., Luo, X., Payne, G.F. and W.E. Bentley (2012) Bridging the Bio-electronic Interface with Biofabrication, Journal of Visualized Experiments, doi:10.379/4321. Liu, Y., V. Javvaji, S. R. Raghavan, W. E. Bentley, G. F. Payne (2012) Glucose Oxidase Mediated Gelation: A Simple Test to Detect Glucose in Food Products. Journal of Agricultural and Food Chemistry, 60(36):8963-8967. Cheng, Y., Luo, X.L., Payne, G.F., Bentley, W.E., and G.W. Rubloff (2012) Biofabrication: Programmable Assembly of polysaccharide hydrogels in microfluidics as biocompatible scaffolds. J. Mater. Chem. 22(16), 7659-7666. Kim, Y.W., Sardari, S.E., Meyer, M.T., Iliadis, A.A., Wu, H.C., Bentley, W.E., and R. Ghodssi (2012) An ALD Aluminum Oxide Passivated Surface Acoustic Wave Sensor for Early Biofilm Detection. Sensors and Actuators B 163:136-145.