侯进 - 山东大学 - 微生物技术国家重点实验室

个人简介

教育背景博士 2006年-2009年山东大学微生物学联合培养博士 2007年-2008年丹麦科技大学系统生物学硕士 2004年-2006年山东大学微生物学学士 2000年-2004年山东农业大学生物技术工作经历起止时间单位名称专业技术职务 2009年-2010年英国Green Biologics Ltd 高级技术协调 2010年-2012年瑞典查尔姆斯技术大学博士后 2012年-2017年山东大学副研究员 2017年-至今山东大学教授

研究领域

合成生物学、代谢工程 1.以酵母为细胞工厂合成生物燃料、生物基化合物及天然产物 2.酵母合成生物学工具的开发和利用 3. 关键代谢物生物传感器的构建及应用 4. 蛋白分泌系统的优化

近期论文

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1. Xiaoxu Chen, Xiaoyu Yang,Yu Shen,Jin Hou*, Xiaoming Bao. Increasing Malonyl-CoA Derived Product through Controlling the Transcription Regulators of Phospholipid Synthesis inSaccharomyces cerevisiae, ACS Synth Biol. 2017 May 19;6(5):905-912. 2. Hongting Tang, Meihui Song, Yao He, Jiajing Wang, Shenghuan Wang, Yu Shen, Jin Hou*, Xiaoming Bao, Engineering vesicle trafficking improves the extracellular activity and surface display efficiency of cellulases inSaccharomyces cerevisiae, Biotechnol Biofuels. 2017 Feb 27;10:53. 3. Jianzhi Zhao,Chen Li, Yan Zhang, Yu Shen,Jin Hou*, Xiaoming Bao*. Dynamic control of ERG20 expression combined with minimized endogenous downstream metabolism contributes to the improvement of geraniol production in Saccharomyces cerevisiae, Microb Cell Fact. 2017 Jan 31;16(1):17. 4. Jin Hou, Chenxi, Qiu, Yu Shen, Hongxing Li, Xiaoming Bao. Engineering of Saccharomyces cerevisiae for the efficient co-utilization of glucose and xylose. FEMS Yeast Res. 2017 Jun 1;17(4). 5. Jin Hou, Chunlei Jiao, Bo Peng, Yu Shen, Xiaoming Bao. Mutation of a regulator Ask10p improves xylose isomerase activity through up-regulation of molecular chaperones inSaccharomyces cerevisiae, Metab Eng. 2016 Nov 38,241-250. 6. Xiaoxu Chen, Xiaoyu Yang,Yu Shen,Jin Hou*, Xiaoming Bao*. Screening Phosphorylation Site Mutations in Yeast Acetyl-CoA Carboxylase Using Malonyl-CoA Sensor to Improve Malonyl-CoA-Derived Product. Front Microbiol. 2018 Jan 25; 9:47. 7. Jianzhi Zhao, Xiaoming Bao, Chen Li,Yu Shen,Jin Hou*. Improving monoterpene geraniol production through geranyl diphosphate synthesis regulation in Saccharomyces cerevisiae, Appl Microbiol Biotechnol. 2016, 100(10):4561-71. 8. Hongting Tang, Wang Shenghuan, Wang Jiajing, Song Meihui, Xu Mengyang, Zhang Mingying, Yu Shen, Jin Hou*, Xiaoming Bao*, N-hypermannose glycosylation disruption enhances recombinant protein production by regulating secretory pathway and cell wall integrity inSaccharomyces cerevisiae. Sci Rep. 2016 May 9;6:25654. 9. Hongting Tang, Xiaoming Bao,Yu Shen, Meihui Song, Shenhuan Wang, Chenqiang Wang,Jin Hou*.Engineering protein folding and translocation improves heterologous protein secretion inSaccharomyces cerevisiae, Biotechnol Bioeng. 2015, 112(9):1872-82 10. Jin Hou, Keith E.J. Tyo, Zihe Liu, Dina Petranovic, Jens Nielsen, Engineering of VesicleTrafficking Improves the Heterologous Protein Production inSaccharomyces cerevisiae, Metab Eng, 2012, 14(2):120-127 11. Jin Hou, Gionata Scalcinati, Marco Oldiges, Goutham N Vemuri. Metabolic impact of increased NADH availability inSaccharomyces cerevisiae, Appl Environ Microb, 2010; 76(3):851-9 12. Jin Hou, Nuno Lages,Marco Oldiges,Goutham N Vemuri. Metabolic impact of redox cofactor perturbations inSaccharomyces cerevisiae, Metab Eng, 2009; 11(4-5):253-261