孟祥锋 - 山东大学 - 微生物技术国家重点实验室

个人简介

教育背景博士 2010.10-2014.12 格罗宁根大学专业：微生物生理硕士 2007.09-2010.07 山东大学专业：微生物学士 2003.09-2007.07 山东大学专业：生物技术（生命科学基地）工作经历起止时间单位名称专业技术职务 2016.12-现在山东大学微生物技术研究院副研究员 2015.1-2016.12 格罗宁根大学博士后

研究领域

糖苷水解酶的结构和功能多糖和寡糖的酶法合成肠道微生物的分离培养肠道微生物的定植和稳态维持机制肠道微生物对外源物质的代谢

近期论文

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Wang L, Zheng F, Zhang W, Zhong Y, Chen G,Meng X*，Liu W (2018)A copper-controlled RNA interference system for reversible silencing of target genes in Trichoderma reesei. Biotechnol Biofuels 11: 33.(*Corresponding author) Wang Z,An N,Xu W,Zhang W,Meng X*,Chen G,Liu W*. (2018)Functional characterization of the upstream components of the Hog1-like kinase cascade in hyperosmotic and carbon sensing in Trichoderma reesei.Biotechnol Biofuels11: 97.(Co-corresponding author). Meng X, Gangoiti J, Bai Y, Pijning T, van Leeuwen SS, Dijkhuizen L (2016)Structure-function relationships of family GH70 glucansucrase and 4,6-α-glucanotransferase enzymes, and their evolutionary relationships with family GH13 enzymes.Cell Mol Life Sci, 73(14):2681-706. Meng X, Pijning T, Dobruchowska JM, Gerwig GJ, Dijkhuizen L (2015)Characterization of the functional roles of amino acid residues in acceptor binding subsite +1 in the active site of the glucansucrase GTF180 enzyme ofLactobacillus reuteri180.J Biol Chem, 290 (50): 30131-30141. Meng X, Dobruchowska JM, Pijning T, López CA, Kamerling JP, Dijkhuizen L (2014)Residue Leu940has a crucial role in the linkage and reaction specificity of the glucansucrase GTF180 of the probiotic bacteriumLactobacillus reuteri180. J Biol Chem, 289 (47):32773-32782. Meng X, Dobruchowska JM, Pijning T, Gerwig GJ, Kamerling JP, Dijkhuizen L (2015) Truncation of domain V of the multidomain glucansucrase GTF180 ofLactobacillus reuteri180 heavily impairs its polysaccharide-synthesizing ability. Appl Microbiol Biotechnol, 99 (14):5885-5894. Meng X, Dobruchowska JM, Pijning T, Gerwig GJ, Dijkhuizen L (2016) Synthesis of new hyper-branched α-glucans from sucrose byLactobacillus reuteri180 glucansucrase mutants. J Agric Food Chem, 64 (2), 433–442. Meng X, Dobruchowska JM, Gerwig GJ, Kamerling JP, Dijkhuizen L (2015) Synthesis of oligo- and polysaccharides byLactobacillus reuteri121 reuteransucrase at high concentrations of sucrose. Carbohydr Res, 414:85-92. Meng X, Pijning T, Dobruchowska JM, Gerwig GJ, Kamerling JP & Dijkhuizen L (2016) Structural determiants of alternating (α1→4) and (α1→6) linkage specificity in reuteransucrase ofLactobacillus reuteri. Sci Rep 6:35261 Meng X, Pijning T, Kralj S, Gerwig GJ, Kamerling JP & Dijkhuizen L (2017) Characterization of the glucansucrase GTF180 W1065 mutant enzymes producing polysaccharides and oligosaccharides with altered linkage specificity.Food Chemistry,217:81-90 . Meng X,Gangoiti J,de Kok N,van Leeuwen SS, Pijning T, Dijkhuizen L (2018)Biochemical characterization of two GH70 family 4,6-α-glucanotransferases with distinct product specificity fromLactobacillus aviarius subsp. aviariusDSM 20655.Food Chemistry,253:236-246