Sylvester, Paul W. - University of Louisian at Monroe - Department of Basic Pharmaceutical Sciences

个人简介

1982 - 1985 Postdoctoral Fellow, Pharmacology Roswell Park Cancer Institute Buffalo, New York 1977 - 1982 Ph.D., Physiology Michigan State University East Lansing, Michigan 1972 - 1976 B.S., Biology Western Michigan University Kalamazoo, Michigan

研究领域

Relationship of hormones and nutrition in breast cancer development and autonomy. Mitogenic and apoptotic signal transduction in normal and neoplastic mammary epithelial cells. Neuroendocrine regulation of anterior pituitary hormone secretion and reproductive function.

近期论文

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Algayadh, I.G. and Sylvester, P.W. (2017) Synergistic Anticancer Effects of Combined g-Tocotrienoland Pterostilbene Is Associated With a Suppression in Rac1/WAVE 2 Signaling in Highly Malignant Breast Cancer Cells. (submitted) Alawin, O.A., Ahmed, R.A., Dronamraju, V., Briski, K.P. and Sylvester, P.W. (2017) γ-Tocotrienol-Induced Disruption of Lipid Rafts in Human Breast Cancer Cells is Associated with a Reduction in Exosome Heregulin Content. Journal of Nutrition and Biochemistry. (submitted) Briski, K.P., Alenazi, F., Shakya, M. and Sylvester, P.W. (2017) Hindbrain A2 Noradrenergic Neuron Adenosine 5’-Monophosphate-Activated Protein Kinase (AMPK) Activation, Upstream Kinase/Phosphorylase Protein Expression, and Receptivity to Hormone and Fuel Reporters of Short-Term Food Deprivation are Regulated by Estradiol. Journal of Neuroscience (in press) Sylvester, P.W. and Tiwari, R.V. (2016) Role of Autophagy in Mediating the Anticancer Effects of Tocotrienols. In: Autophagy in Current Trends in Cellular Physiology and Pathology, Eds. Andrea Koric, InTech Publications. http://dx.doi.org/10.5772/64131 Alawin, O., Ahmed, R.A., Dronamraju, V., Algayadh, I.G., Kalloub, A.A. and Sylvester, P.W. (2016) Role of Endoplasmic Retiulum Stress in Mediating the Anticancer Effects of Tocotrienols. In: Endoplasmic Reticulum Stress: Regulation, Function and Role in Health and Disease, pp 101-128. Eds, Cameron Wagner, Nova Science Publisher, Inc. Hauppauge, NY Algayadh, E.G., Dronamraju V. and Sylvester, P.W. (2016) g-Tocotrienol Inhibition of Cell Migration and Invasion Is Associated With a Suppression in WAVE 2 Signaling in Highly Malignant Breast Cancer Cells. Biological and Pharmaceutical Bulletin 39(12):1974-1982 Ahmed, A.R., Alawin, O.A. and Sylvester, P.W. (2016) γ-Tocotrienol reversal of Epithelial-to-Mesenchymal Transition in Human Breast Cancer Cells is Associated with an Inhibition in Canonical Wnt Signaling. Cell Proliferation 49:460-470 Klionsky, D.J., Abdelmoshsen, K., Abe, A., et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3nd edition). Autophagy 12:1-222 Alawin, O.A., Ahmed, R.A., Ibrahim, B.A., Briski, K.P. and Sylvester, P.W. (2016) Antiproliferative effects of γ-tocotrienol are associated with lipid raft disruption in HER2 positive breast cancer cells. Journal of Nutritional Biochemistry 27:266-277 Abu Fayyad, A.; Behery, F. Sallam, A., Alqahtani, S., Ebrahim, H., El Sayed, K. Kaddoumi, A., Sylvester, P.W., Carroll, J., Cardelli, J. and Nazzal, S. (2015) PEGylated γ-tocotrienol isomer of vitamin E: Synthesis, characterization, in vitro cytotoxicity, and oral bioavailability. European Journal of Pharmaceutics and Biopharmaceutics 96:185-195 Tiwari, R.V., Parajuli, P. and Sylvester, P.W. (2015) Synergistic Anticancer Effects of Combined γ-Tocotrienol and Oridonin Treatment is Associated with the Induction of Autophagy. (2015) Molecular and Cellular Biochemistry 93:306-320. doi: 10.1139/bcb-2014-0123 Parajuli, P., Tiwari, R.V. and Sylvester P.W. (2015) Anticancer Effects of g-Tocotrienol are Associated with a Suppression in Aerobic Glycolysis. Biological and Pharmaceutical Bulletin. 38: 1352-1360. doi: 10.1248/bpb.b15-00306 Parajuli, P., Tiwari, R.V., and Sylvester, P.W. (2015) Antiproliferative Effects of g-Tocotrienol are Associated with a Suppression in c-Myc Expression in Mammary Tumor Cells”. Cell Proliferation. 48:421-432 Tiwari, R.V., Parajuli, P., and Sylvester, P.W. (2015) g-Tocotrienol-Induced Autophagy Promotes Endoplasmic Reticulum Stress Mediated Apoptosis in Breast Cancer. Biochemistry and Cell Biology. 93:306-320. doi: 10.1139/bcb-2014-0123 Alqahtani, S., Simon, L., Astete, C., Alayoubi, A., Sylvester, P.W., Nazzal, S., Shen, Y., Xu, Z., Kaddoumi, A., and Sabliov, C.M. (2015) Cellular uptake, antioxidant and antiproliferative activity of entrapped α-tocopherol and γ-tocotrienol in poly (lactic-co-glycolic) acid (PLGA) and chitosan covered PLGA nanoparticles (PLGA-Chi) Journal of Colloid and Interface Science 445:243-251. doi:10.1016/j.jcis.2014.12.083 Sylvester, P.W. (2014) Combined g-Tocotrienol and Met Inhibitor Treatment Suppresses Mammary Cancer Cell Proliferation, Epithelial-to-Mesenchymal Transition, and Migration. Journal of Oil Palm, Environment & Health 2014, 5:18-30. doi:10.5366/jope.2014.03 Sylvester, P.W. (2014) Targeting Met mediated epithelial-mesenchymal transition in the treatment of cancer. Clinical and Translational Medicine 3:30. http://www.clintransmed.com/content/3/1/30, doi:10.1186/s40169-014-0030-5 Ananthula, S., Parajuli, P., Behery, F.A., El Sayed, K.A., and Sylvester, P.W. (2014) δ-Tocotrienol Oxazine Derivative Antagonizes Mammary Tumor Cell Compensatory Responses to CoCl2-Induced Hypoxia. Biomed Res International 2014:285752. doi: 10.1155/2014/285752 Alayoubi, A., Abu-Fayyad, A., Rawas-Qalaji, M.M., Sylvester, P.W. and Nazzal, S. (2015) Effect of lipid viscosity and high-pressure homogenization on the physical stability of “Vitamin E” enriched emulsion. Pharmaceutical Development and Technology 20:555-561. doi: 10.3109/10837450.2014.898655 Alqahtani, S. Alayoubi, A., Nazzal, S., Sylvester, P.W. and Kaddoumi, A. (2014) Enhanced solubility and oral bioavailability of g-tocotrienol using a self-emulsifying drug delivery system (SEDDS). Lipids 49:819-829 Ananthula, S., Parajuli, P., Behery, F.A., Alayoubi, A.Y., El Sayed, K.A., Nazzal, S. and Sylvester, P.W. (2014) Oxazine Derivatives of γ- and δ- Tocotrienol Display Enhanced Anticancer Activity In Vivo. Anticancer Research 34:2715-2726 Alayoubi, A., Ayoub, N.M., Malaviya, A., Sylvester, P.W., and Nazzal, S. (2014) Entrapment Into Nanoemulsions Potentiates the Anticancer Activity of Tocotrienols Against the Highly Malignant (+SA) Mouse Mammary Epithelial Cells. Journal of Nanoscience and Nanotechnology 14:4002-4005 Malaviya, A., and Sylvester P.W. (2014) Antiproliferative Effects of combined treatment of γ–Tocotrienol with PPARγ Agonists or Antagonists mediated through PPARγ-independent mechanisms in breast cancer cells. PPAR Research http://dx.doi.org/10.1155/2014/439146 Sylvester, P.W., Ananthula, S., Parajuli, P., Akl, M.R., Malaviya, A., Tiwari, R.V., Alawin, O., and Ayoub, N.M. (2014) Potential role of tocotrienols in the treatment and prevention of breast cancer. Biofactors 40(1):49-58. doi: 10.1002/biof.1116 Malaviya, A., Parajuli, P. and Sylvester, P.W. (2014) Synergistic Antiproliferative Effects of Combined PPARγ Antagonist and γ-Tocotrienol Treatment Suppress Adipogenic Factors in Breast Cancer Cells. JPANS 4:43-56. DOI: http://dx.doi.org/10.6000/1927-5951.2014.04.01.7