Liu, Yong-Yu - University of Louisian at Monroe - Department of Basic Pharmaceutical Sciences

个人简介

1997 - 1999 Postdoctoral Fellow, Molecular Oncology John Wayne Cancer Institute Santa Monica, CA 1996 - 1997 Postdoctoral Fellow, Molecular Endocrinology Departments of Physiology & Internal Medicine University of Manitoba, Canada 1993 - 1996 Postdoctoral Fellow, Molecular Endocrinology Laboratory of Molecular Medicine Department of Internal Medicine University of Rome-Tor Vergate Rome, Italy 1986 - 1989 Ph.D., Biochemistry Shanghai University of Traditional Chinese Medicine Shanghai, P.R. China 1984 - 1985 Intern, Medicine and Surgery Soochow University School of Medicine Hospital Suzhou, P.R. China 1979 - 1984 M.D., Medicine and Surgery Soochow University School of Medicine Hospital Suzhou, P.R. China

研究领域

Tumor cell response to chemotherapy and gene regulation

近期论文

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Hosain SB, Khiste SK, Uddin MB, Vorubindi V, Igram C, Zhang S, Hill RA, Gu X and Liu YY. 2016. Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells. Oncotarget Aug 10 [Epub ahead of print] PMID: 27517620 Patwardhan GA, Hosain SB, Liu DX, Khiste SK,Zhao Y, Bielawski J, Jazwinski SM, Liu Y.Y. 2014. Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells. Biochim Biophys Acta 1841(11):1571-1580 PMID: 25195822 Liu, Y.Y., Hill, R.A. and Li, Y.T. Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance. 2013. Adv Cancer Res 117:59-89 (citation>40) PMID: 23290777 Gupta, V., Liu, Y.Y. 2013. New insights on glucosylceramide synthase in cancer drug resistance and myelosuppression. Biochem & Pharmacol 2:120 PMID: 25401049 Hosain, S.B., Hill, R.A., and Liu, Y.Y. 2013. The role of sphingolipids in modulating pluripotency of stem cells. Trends in Stem Cell Proliferation and Cancer Research by Rodrigo Resende, Henning Ulrich, Springer, ISBN 978-94-007-6210-7, p167-191 Gupta, V., Bhinge, K.N., Hosain, S.B., Xiong, K., Gu, X., Shi, R., Ambudkar, S., Jazwinski, S.M. and Liu, Y. Y. 2012. Ceramide glycosylation catalyzed by glucosylceramide synthase is a critical process maintaining the stemness of breast cancer stem cells. J Biol Chem 278(44):37195-205 (highlighted inASBMB News, citation>30) PMID: 22936806 Bhinge, K., Gupta, V., Hosain, S.B., Meyer, S.A., Blaylock, B., Zhang, Q., Liu, Y.Y. 2012. The opposite effects of doxorubicin on bone marrow stem cells versus breast cancer stem cells depend on glucosylceramide synthase. Int. J. Biochem. Cell Biol. 44(11):1770-1778 PMID: 22728310 Liu, Y.Y. 2011.Resuscitation of wild-type p53 tumor suppressor by disrupting ceramide glycosylation: a novel approach to target mutant p53 tumors.Cancer Res.71(20):6295-99 PMID: 21972148 Liu, Y.Y., Patwardhan, G.A., Xie, P., Gu, X., Giuliano, A.E., and Cabot, M.C. 2011. Glucosylceramide synthase, a factor in modulating multidrug resistance, is overexpressed in metastatic breast carcinoma. Int. J Oncol 39:425-431 (citation>30) PMID: 21617856 Liu, Y.Y., Patwardhan, G.A., Bhinge, K., Gupta, V., Gu, X., and Jazwinski, S.M., 2011. Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells. Cancer Res. 71(6):2276-85 (citations>40) PMID: 21278235 Gupta, V., Zhang, Q. and Liu, Y.Y. 2011. Evaluation of anticancer agents using flow cytometry analysis of cancer stem cells. Methods Mol Biol. 716:179-91. PMID: 21318907 Patwardhan, G.A., Liu, Y.Y. 2011. Sphingolipids and expression regulation of genes in cancer. Prog. Lipid Res. 50:104-114 (Most Read Article in 2011, citations>60) PMID: 20970453 Liu, Y.Y., Gupta, V., Patwardhan, G.A., Yin, D., Bhinge, K., Zhao, Y., Bao, J., Mehendale, H., Cabot, M. C., Li, Y., and Jazwinski, S.M. 2010. Glucosylceramide Synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. Mol Cancer 9(1):145 (highly accessed, citations>90) PMID: 20540746 Patwardhan, G.A., Gupta, V., Huang, J., Gu, X., Liu, Y.Y. 2010. Direct assessment of P-glycoprotein to determine tumor response to chemotherapy. Biochem. Pharmcol. 80:72-79 (citation>20) PMID: 20298675 Gupta, V., Patwardhan, G.A., Zhang, Q., Senkal, C.E., Ogretmen, B., Cabot, M.C., Jazwinski, S.M., and Liu, Y.Y. 2010. Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate the enzyme activity of glucosylceramide synthase. J. Lipid Res 51:866-874 (highlighted in ASBMB Today; citation>16). PMID: 19826105 Patwardhan, G.A., Zhang, Q., Yin, D., Gupta, V., Bao, J., Senkal, C.E., Ogretmen, B., Cabot, M.C., Jazwinski, S.M., Liu, Y.Y. 2009. A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis. PLoS One 4(9):e6938 (citations>40) PMID: 19742320 Liu, Y.Y.,Yu, J.Y., Yin, D., Patwardhan, G., Gupta, V., Hirabayashi, Y., Holleran, W.M., Jazwinski, S.M., Giuliano, A.E., Gouaze-Andersson, V., Consoli, D.P., Cabot, M.C. 2008. A role for ceramide in driving cancer cell resistance to doxorubicin. FASEB J. 22, 2541-2551 (citations >100) PMID: 18245173 Liu, Y.Y., Han, T.Y, Yu, J.Y., Bitterman, A., Le, A., Giuliano, A.E., and Cabot, M.C. 2004. Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells. J Lipid Res 45:933-940 (citations >80) PMID: 14967819 Liu, Y.Y., and Cabot, M.C. 2004. Development of a mammalian Tet-on expression cell line: glucosylceramide synthase regulates TNF-a-induced apoptosis. Methods Mol. Biol. 249:177-192 PMID: 14573900 Liu,Y.Y.,Han, T.Y., Giuliano, A.E. and Cabot, M.C. 2001. Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J.15:719-730 (citations >280) PMID: 11259390 Liu, Y.Y.,Han, T.Y., Giuliano, A.E., Hansen, N., and Cabot, M.C. 2000. Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance. J. Biol. Chem. 275:7138-7143 (citation>140). PMID: 10702281 Liu Y.Y.,Han, T.Y, Giuliano A.E., and Cabot, M.C. 1999. Glucosylceramide synthase potentiates cellular resistance to TNF-a induced apoptosis. Exp. Cell Res.252:464-470 (citations >80). PMID: 10527636 Liu Y.Y., Rajkumar K. and Murphy L.J. 1999. Hepatic regeneration in insulin-like growth factor binding protein-1 transgenic mice. J. Hepatol. 30:674-80. PMID:10207810 Liu Y.Y.,Han T.Y., Giuliano A.E. and Cabot M.C. 1999. Expression of glucosylceramide synthase converting ceramide to glucosylceramide impacts adriamycin resistance in human breast cancer cells. J. Biol. Chem. 274:1140-1146 (citation>280). PMID: 9873062