Jois, Seetharama - University of Louisian at Monroe - Department of Basic Pharmaceutical Sciences

个人简介

1994 Ph.D., Molecular Biophysics Indian Institute of Science Molecular Biophysics Unit Bangalore, India 1984 - 1986 M.Sc., Solid State Physics University of Mysore Karnataka, India 1981 - 1984 B.Sc., Physics, Chemistry, Mathematics University of Mysore Karnataka, India

研究领域

Protein-protein interactions play an important role in a wide range of physiological and pathological processes. The interaction between the proteins involves small surface binding epitopes. Thus, protein-protein interactions can be modulated by blocking surface epitopes of proteins. Hence, inhibition of protein-protein interaction has a tremendous impact on understanding the structural basis of these interactions and in developing new therapeutic strategies for many human diseases. Our group is focusing on two important areas of research to tweak the protein-protein interactions

近期论文

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Sandeep Pallerla, Ted Gauthier, Rushikesh Sable, Seetharama D. Jois. Design of a doxorubicin-peptidomimetic conjugate that targets HER2-positive cancer cells (2016) Eur. J. Med. Chem. (in press). Sable, R., Durek, T., Taneja, V., Craik, D., Pallerla, S., Jois, Seetharama. Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein-Protein interaction. (2016) ACS Chem. Biol. 11(8):2366-74. Krystal R. Fontenot, Benson G. Ongarora, Logan E. LeBlanc, Zehua Zhou, Seetharama D. Jois and M. Gra?a H. Vicente.Targeting of the epidermal growth factor receptor with mesoporphyrin IX-peptide conjugates. (2016) J Porphyr Phthalocyanines.20:352-366. Luckey D, Gokhale A, Jois S, Johnson A, Behrens M, Luthra H, Taneja V. (2015) CD74/DQA1 dimers predispose to the development of arthritis in humanized mice.Immunology. 147(2):204-211. Shanthi Kanthala, Christopher Mill, David Riese, Mihir Jaiswal, Seetharama Jois (2015). Expression and purification of HER2 extracellular domain protein in Schneider2 Insect cells. Protein Expr Purif. 125: 26-33. Rushikesh Sable, Seetharama Jois (2015). Surfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI Inhibitors. Molecules 20:11569-603. Gokhale, A.S., Sable, R., Walker, J.D., McLaughlin, L., Kousoulas, K.G., Jois, S.D. (2015). Inhibition of cell adhesion and immune responses in the mouse model of collagen-induced arthritis with a peptidomimetic that blocks CD2-CD58 interface interactions. Biopolymers. 104(6):733-42. Samy, R.P., Thwin, M.M., Stiles, B.G., Satyanarayanajois, S., Chinnathambi, A., Zayed, M.E., Alharbi, S.A., Siveen, K.S., Sikka, S., Kumar, A.P., Sethi, G., Lim, L.H. (2015). Novel phospholipase A2 inhibitors from python serum are potent peptide antibiotics.Biochimie. Apr;111:30-44. Epub 2015 Jan 9. Kanthala S, Pallerla S, Jois S. Current and future targeted therapies for non-small-cell lung cancers with aberrant EGF receptors.Future Oncol. (2015) 11(5):865-78. Kanthala, S, Banappagari, S., Gokhale, A., Gu Xin, Yunfeng Zhao, Youn-Yu Liu, Seetharama Jois. Novel Peptidomimetics For Inhibition of HER2:HER3 Heterodimerization in HER2 Positive Breast Cancer. Chem. Biol. Drug Des. (2014) 85:702-714. Ameya Gokhale, Satyanarayanajois, S.D. (2014). Peptides and peptidomimetics as immunomodulators. Immunotherapy 6: 755-774. Kanthala, S., Gauthier, T., Satyanarayanajois, S.D. (2013). Structure-activity relationships of peptidomimetics that inhibit PPI of HER2-HER3.Biopolymers. 101: 693-702. Perumal Samy, R., Gopalakrishnakone, P., Satyanarayanajois, S.D., Stiles, B.G., Chow, V.T.K. (2013). Snake venom proteins and peptides as novel antibiotics against microbial infections. Current Proteomics. (edited by Sergio Sánchez Esquivel), Caister Academic Banappagari, S., McCall, A., Fontenot, K., Vicente, M.G.H., Gujar, A., Satyanarayanajois, S.D. (2013). Design, synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domain. Eur. J. Med. Chem. Accepted. Gokhale, A., Kanthala, S., Latendresse, J., Taneja, V., Satyanarayanajois,S. (2013). Immunosuppression by Co-stimulatory Molecules: Inhibition of CD2-CD48/CD58 Interaction by Peptides from CD2 to Suppress Progression of Collagen-induced Arthritis in Mice.Chem Biol Drug Des. Mar 26. doi: 10.1111/cbdd.12138. [Epub ahead of print] Alayoubi, A.Y., Anderson, J.F., Satyanarayanajois,S.D., Sylvester, P.W., Nazzal, S. (2012). Concurrent delivery of tocotrienols and simvastatin by lipid nanoemulsions potentiates their antitumor activity against human mammary adenocarcenoma cells.Eur J Pharm Sci. 48: 385-392. Alayoubi, A., Kanthala, S., Satyanarayanajois,S.D., Anderson, J.F., Sylvester, P.W., Nazzal, S. (2013). Stability and in vitro antiproliferative activity of bioactive "Vitamin E" fortified parenteral lipid emulsions.Colloids Surf B Biointerfaces. 103: 23-30. Banappagari, S., Corti, M., Pincus, S., Satyanarayanajois, S.D. (2012). Inhibition of protein-protein interaction of HER2-EGFR and HER2-HER3 by a rationally designed peptidomimetic. J. Biomol. Struct. Dyn. 30: 594-606 Benson G. Ongarora, Krystal R. Fontenot, Xiaoke Hu, Inder Sehgal, Seetharama D. Satyanarayanajois, and M. Graca M. H. Vicente. (2012). Phthalocyanine?Peptide Conjugates for Epidermal Growth Factor Receptor Targeting. J. Med. Chem. 55, 3725?3738 Alaadin Alayoubi, Seetharama D. Satyanarayanajois, Paul W. Sylvester, Sami Nazzal. (2012). Molecular modeling and multisimplex optimization of tocotrienol-rich Self Emulsified Drug Delivery Systems. Int. J. Pharm. 426: 153– 161 Bhinge, K.N., Gupta, V., Hosain, S.B., Satyanarayanajois, S.D., Meyer, S.A., Blaylock, B., Zhang, Q.J., Liu, Y.Y. (2012). The opposite effects of doxorubicin on bone marrow stem cells versus breast cancer stem cells depend on glucosylceramide synthase. Int. J. Biochem. Cell Biol. 44:1770-1778 Satyanarayanajois, S.D., Hill, R.A. (2011). Medicinal chemistry for 2020. Future Med Chem. 14: 1765-1786