El Sayed, Khalid A. - University of Louisian at Monroe - Department of Basic Pharmaceutical Sciences

个人简介

1993 Ph.D. Pharmacognosy Mansoura University, Egypt Dissertation: A Study of Stapelia Pregnanes and Veratrum Alkaloids (Profs. A. F. Halim & J.D. McChesney) 1989 M. Sc. Pharmacognosy Mansoura University, Egypt Thesis: Pharmacognostic Study of Certain Plants Belonging to the Family Asclepiadaceae. (Prof. A. F. Halim) 1983 B.S. Pharmacy Mansoura University, Egypt

近期论文

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Ebrahim HY, Elsayed HE, Mohyeldin MM, Akl MR, Bhattacharjee J, Egbert S, El Sayed KA. Norstictic acid inhibits breast cancer cell proliferation, migration, invasion, and in vivo invasive growth through targeting c-Met. 2016. Phytotherapy Research, 30, 557–566 Mohyeldin MM, Akl MR, Dragoi AM, Cardelli JA, El Sayed KA. The oleocanthal-based homovanillyl sinapate as a novel c-Met inhibitor. 2016. Oncotarget, 7, 32247-32273 Mohyeldin MM, Busnena BA, Akl MR, Dragoi AM, Cardelli JA, El Sayed KA. Novel c-Met inhibitory olive secoiridoid semisynthetic analogs for the control of invasive breast cancer. 2016. Eur J Med Chem. 118, 299-315 Ebrahim HY, El Sayed KA. Antiangiogenic marine natural product scaffolds. 2016. Marine Drugs, 14, 57; doi:10.3390/md14030057 Mady MS, Mohyeldin MM, Ebrahim HY, Elsayed HE, Houssen WE, Haggag EG, Soliman RF, El Sayed KA. The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion. 2016. Bioorg Med Chem. 24, 113-122 Qosa H, Batarseh Y, Mohyeldin M, El Sayed KA, Keller J, Kaddoumi A.Oleocanthal enhances amyloid-β clearance from the brains of TgSwDI mice and in vitro across a human blood-brain barrier model. ACS Chemical Neuroscience. 2015. 6(11), 1849-1859 Abu-Fayyad A, Behery F, Sallam A, Alqahtani S, Ebrahim H, El Sayed KA, Kaddoumi A, Sylvester PW, Carroll JL, Cardelli JA, Nazzal S. PEGylated γ-tocotrienol isomer of vitamin E: Synthesis, characterization, in vitro cytotoxicity, and oral bioavailability. 2015, Eur J Pharm Biopharm, 96, 185-195 Gray AL, Coleman DT, Castorea RF, Mohyeldin MM, El Sayed KA, Cardelli JA. Isothiocyanatostilbenes as novel c-Met inhibitors. 2015. Oncotarget, 6(38), 41180-41193 Khanfar MA, Bardaweel SK, Akl MR, EI Sayed KA. Olive oil-derived oleocanthal as potent inhibitor of mammalian target of rapamycin: Biological evaluation and molecular modeling studies. 2015. Phytotherapy Research, 29(11), 1776-1782 Zhang Y, Zhang Y-K, Wang Y-J, Vispute SG, Jain S, Li J, Chen Y, Youssef DTA, El Sayed KA, Chen ZS. Esters of the marine-derived triterpene sipholenol A reverse P-gp-mediated drug resistance. 2015. Marine Drugs, 13, 2267-2286 Martins AH, Hu J, Xu Z, Mu C, Alvarez P, Ford BD, El Sayed K, Eterovic VA, Ferchmin PA, Hao J. Neuroprotective activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in rodent models of brain ischemia. 2015. Neuroscience, 291, 250-259 Akl MR, Ayoub NM, Ebrahim HY, Foudah AI, Mohyeldin MM, Orabi KY, El Sayed KA. Araguspongine C induces autophagic death in breast cancer cells through suppression of c-Met and HER2 receptor tyrosine kinase signaling. 2015. Marine Drugs, 13, 288-311 Ananthula S, Parajuli P, Behery FA, Alayoubi AY, Nazza Sl, El Sayed KA, Sylvester PW. 2014. Oxazine derivatives of ??-and ??-tocotrienol display enhanced anticancer activity in vivo,” Anticancer Research, 34, 2715-2726 Ananthula S, Parajuli P, Behery FA, Alayoubi AY, Nazza Sl, El Sayed KA, Sylvester PW. 2014. ??-Tocotrienol oxazine derivative antagonizes mammary tumor cell compensatory response to CoCl2-induced hypoxia. BioMed Research International Volume 2014, Article ID 285752, http://dx.doi.org/10.1155/2014/285752 Sallam AA, Mohyeldin MM, Foudah AI, Akl MR, Nazzal SM, Meyer SA, Yong-Yu Liu YY, El Sayed KA. Marine natural products-inspired phenylmethylene hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling. 2014. Organic & Biomolecular Chemistry 12, 5295–5303 Akl MR, Elsayed HE, Ebrahim HY, Haggag EG, Kamal AM, El Sayed KA. 3-O-[N-(p-fluorobenzenesulfonyl)-carbamoyl]-oleanolic acid, a semisynthetic analog of oleanolic acid, induces apoptosis in breast cancer cells. 2014. European Journal of Pharmacology. 740, 209–217 Elsayed HE, Akl MR, Ebrahim HY, Sallam AA, Haggag EG, Kamal AM, El Sayed KA. Discovery, optimization and pharmacophore modeling of oleanolic acid and analogs as breast cancer cell migration and invasion inhibitors via targeting Brk/Paxillin/Rac1 axis. 2015. Chemical Biology & Drug Design 85, 231-243 Akl MR, Busnena1 BA, Mohyeldin MM, Foudah AI, Ayoub NM, Liu YY, El Sayed KA. Olive phenolics as c-Met inhibitors: (-)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models. 2014. PlosOne. May 2014, 9 ( 5) e97622 Akl M, Foudah A, Ebrahim H, El Sayed KA. The marine-derived sipholenol A-4-O-3′,4′-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through suppression of Brk and FAK signaling. 2014. Marine Drugs 12, 2282-2304 Foudah A, Sallam A, Akl M, El Sayed KA. Optimization, pharmacophore modeling, and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors. 2014. European Journal of Medicinal Chemistry. 73 (2) 310-324 Sallam AA, Ayoub NA, Foudah AI, Gissendanner CR, Meyer SA, El Sayed KA. Indole diterpene alkaloids as novel inhibitors of the Wnt/b-catenin pathway in breast cancer cells. 2013. European Journal of Medicinal Chemistry. 70, 594-606 Sallam AA, Houssen WE., Foudah AI, Gissendanner CR, Orabi KY, El Sayed KA. 2013. Discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors. Medicinal Chemistry Communication 4 (10), 1360-1369 El Sayed KA, Foudah AI, Mayer AMS, Crider AM, Song D. Synthesis, microbial transformation, and pharmacological evaluation of 4,5-dihydronaphtho[2,1-b]furan-2-ones and related analogues. 2013. Medicinal Chemistry Communication, 4, 1231-1238 El Sayed KA, Chelette, CT. 2014. Design and evaluation of laboratory exercises to teach clinically-relevant chemistry of antibiotics using chemical and spectral experimental approaches. American Journal of Pharmaceutical Education, 78(2), Article 37 Orabi KY, Abaza MS, El Sayed KA, Elnagar AY, Al-Attiyah RJ, Guler RP. Selective growth inhibition of human malignant melanoma cells by syringic acid-derived proteasome inhibitors. 2013. Cancer Cell International 13, 82 (http://www.cancerci.com/content/13/1/82).