Garlapati , Srinivas - University of Louisian at Monroe

个人简介

Ph.D. in Biotechnology Madurai Kamaraj University, India Post-doctoral studies in Molecular Parasitology Ben Gurion University of the Negev, Israel University of California San Francisco, USA

研究领域

Our lab studies the biology of the protozoan human parasite Giardia lamblia. It is primarily transmitted by contaminated water and causes a diarrheal disease called giardiasis. Around 2 million people are infected annually and of which most of them are children who suffer from long lasting illness. Currently available drugs to treat this debilitating disease have adverse side effects. We are interested in elucidating the molecular mechanism of translation initiation in the parasite in order to develop parasite specific drugs. Our current projects in the lab includes a) identification of translation initiation factors that recruit the protein synthetic machinery to capped mRNAs with a very short 5’UTRs (funded by Louisiana Board of Regents and LBRN-NIH) and b) screening for anti-giardial compounds in plant extracts.

近期论文

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Srinivas Garlapati, Ashesh Saraiya and Ching C. Wang (2011). La antigen homologue in Giardia lamblia is required for Giardiavirus internal ribosome entry site mediated translation. PLoS One 6(3); e18263 Srinivas Garlapati and Ching C. Wang (2009). Giardiavirus internal ribosome entry site has an apparently unique mechanism of initiating translation. PLoS One 4(10): e7435 Srinivas Garlapati and Ching C. Wang (2005). Structural elements in the 5’untranslated region of giardiavirus transcript essential for internal ribosome entry site mediated translation initiation. Eukary. Cell. 4:742-754. Srinivas Garlapati and Ching C. Wang (2004). Identification of a novel internal ribosome entry site in giardiavirus that extends to both sides of the initiation codon. J.Biol. Chem. 279:3389-3397. Srinivas Garlapati and Ching C.Wang (2002). Identification of an essential pseudoknot in the downstream putative internal ribosome entry site in giardiavirus transcript. RNA8:601-611. (Recommended by Faculty of 1000) Srinivas Garlapati, Jim Chou?, and Ching C. Wang (2001). Specific secondary structures in the capsid coding region of Giardiavirus transcript are required for its translation in Giardia lamblia. J. Molecular Biology308: 623-638. (Recommended by Faculty of 1000) (? Undergraduate student). Alon Zilka*, Srinivas Garlapati*, Edit Dahan, Victoria Yoalsky, and Michal Shapira (2001). Developmental regulation of heat shock protein 83 in Leishmania. J. Biological Chemistry 276(51): 47922-47929. (* Equal contributions) Michal Shapira, Alon Zilka, Srinivas Garlapati, Edit Dahan, Irit Dahan and Victoria Yovesky (2001). Post transcriptional control of gene expression in Leishmania. Med. Microbiol. Immunology. 190:23-26. Srinivas Garlapati, Edith Dahan, and Michal Shapira (1999). Effect of acidic pH on heat shock gene expression in Leishmania amazonensis. Molecular and Biochemical Parasitology 100(1): 95-101. Srinivas Garlapati, Radi Aly, and Michal Shapira (1998). Genus specific expression from the SL RNA promoter of Leishmania amazonensis. J. Experimental Parasitology 89(2): 266-270.