Liu, Xiaogang - Singapore University of Technology and Design

个人简介

Dr. Liu Xiaogang has a multidisciplinary education, work, and research background. He studied in electrical and electronic engineering (2002—2006, B.Eng.), materials science and engineering (2008—2009, M.Sc./M.Eng.) and physical chemistry (2010—2014, PhD). He also worked in the industry as a product engineer (2006—2008, semiconductor), a research engineer (2010, optics), and a research associate (2013, solar cells). He began his independent research with a SMART Scholar Fellowship (2014—2016), and joined SUTD as an Assistant Professor in 2017. Education PhD, Cavendish Laboratory (Department of Physics), University of Cambridge (UK), 2014. M.Eng., Department of Materials Science and Engineering, Massachusetts Institute of Technology (USA), 2009. M.Sc., Singapore-MIT Alliance, National University of Singapore, 2009. B.Eng., School of Electrical and Electronic Engineering, Nanyang Technological University (Singapore), 2006. Awards SMART Scholar Fellowship, Singapore-MIT Alliance for Research and Technology, 2014—2016 Clean Energy Scholarship, National Research Foundation of Singapore, 2010—2014 Singapore-MIT Alliance Graduate Fellowship, National University of Singapore, 2008—2009 Singapore GLC Undergraduate Scholarship, Nanyang Technological University, 2002—2006

研究领域

We use both “bottom-up” and “top-down” approaches to systematically summarizing molecular design rules. In the “bottom-up” approach, we employ quantum chemical calculations and experimental characterizations to understand the molecular origins of a particular dye, before generalizing such knowledge to a wide range of compounds. In the “top-down” approach, we perform “data mining” in chemical databases and search patterns between molecular structures and their properties; subsequently, we validate these patterns using quantum chemical calculations, and thereby generate molecular design rules. These rational molecular design rules enable us to develop novel fluorescent dyes and sensors with enhanced performance. A deep understanding of the structure-property relationships of fluorophores also permits us to reveal the photophysics and photochemistry of various fluorescent compounds. Fluorophore Engineering Fluorescent Probe Development Mechanisms and Insights

近期论文

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De Novo Zwitterionic Strategy of Ultra-stable Chemiluminescent Probes: Highly Selective Sensing Singlet Oxygen in FDA-approved Phototherapy Y. Lu, Y. Zhang, X. Wu, R. Pu, C. Yan, W. Liu, X. Liu, Z. Guo*, W. Zhu Chemical Science, 2024, DOI: 10.1039/D4SC01915F. Photoinduced Charge Centralization Quenches the Fluorescence of Conjugation-Fused Tetrazine Labels with Red-to-Near-Infrared Emissions T. Shen, X. Liu* Bioconjugate Chemistry, 2024, DOI: 10.1021/acs.bioconjchem.4c00227. Enhanced Reactivity of Acridinium Perchlorate: Harnessing Redox Mediators for Trace Chloride Activation in Hydrogen Atom Transfer Photocatalysis M. Wu, Z. Wu, H. T. Ang, B. Wang, T. Liu, S. Wu, Z. Lei, M. W. Liaw, S. Chanmungkalakul, C. K. Lee, X. Liu, Y. Lu*, J. Wu* ACS Catalysis, 2024, 14, 9364–9373. Molecular design and architectonics towards film-based fluorescent sensing R. Huang, T. Liu, H. Peng, J. Liu, X. Liu*, L. Ding*, Y. Fang* Chemical Society Reviews, 2024, 53, 6960-6991. Photosensitizer-Amplified Antimicrobial Materials for Broad-spectrum Ablation of Resistant Pathogens in Ocular Infections C. Lochenie, S. Duncan, Y. Zhou, L. Fingerhut, A. Kiang, S. Benson, G. Jiang, X. Liu, B. Mills*, M. Vendrell* Advanced Materials, 2024, 2404107, DOI: 10.1002/adma.202404107. Strategies to Enhance the Electrochromic Properties of Conjugated Polymers Bearing Pyromellitic Diimide Acceptors B. Y. K. Hui, K. L. O. Chin, J. J. L. Lim, X. Y. D. Soo, X. Lu, Q. Zhu, X. Liu, J. Xu*, M. Chua* Chemistry – An Asian Journal, 2024, 19, e202400236, DOI: 10.1016/j.snb.2024.135864. Chromene-derived red-fluorescent probes for sulfite detection in food and living cells based on an integrated ICT&PET platform T. Liang, S. Liu, T. Shen, X. Chen, X. Li, X. Yan, X. Sun, M. Tian, C. Wu, X. Sun, K. Zhong, Y. Li*, X. Liu*, L. Tang*Sensors and Actuators B: Chemical, 2024, 413, 135864. Synergistic Inter- and Intramolecular Aggregation of Dimeric Cyanine Dyes Affords Highly Efficient In Vivo Self-Delivery and Photothermal Therapy Y. Hou, J. Li, G. Jiang, T. Xia, Z. Li, H. Gu, X. Liu*, Q. Yao, C. Zhang, W. Liu, J. Du, W. Sun, J. Fan*, X. Peng Advanced Functional Materials, 2024, 2316452, DOI: 10.1002/adfm.202316452. Unlocking Multicolor Emissions in the Crystalline State through Dimerization and Configurational Transformation of a Single Fluorophore Y. Shao, R. Huang*, G. Jiang, Q. Shi, H. Wei, G. Wang, W. Chi, H. Peng*, X. Liu* and Y. Fang* Chemistry of Materials, 2024, 36, 3223–3232. “Superimposed” spectral characteristics of fluorophores arising from cross-conjugation hybridization K. An, Q. Qiao, Lovelesh, S. A. A. Abedi, X. Liu*, Z. Xu* Chinese Chemical Letters, 2024, 109786, DOI: 10.1016/j.cclet.2024.109786. 1,2-BF2 Shift and Photoisomerization Induced Multichromatic Response Q. Qi, S. Huang, X. Liu*, I. Aprahamian* Journal of the American Chemical Society, 2024, 146, 6471–6475. Auxochrome Dimethyl-Dihydroacridine Improves Fluorophores for Prolonged Live-Cell Super-Resolution Imaging X. Ren, C. Wang, X. Wu, M. Rong, R. Huang, Q. Liang, T. Shen, H. Sun, Z. Zhang, R. Zhang*, X. Liu*, X. Song*, and J. W. Foley Journal of the American Chemical Society, 2024, 146, 6566-6579. Photoinduced electron transfer endows fluorogenicity in tetrazine-based near-infrared labels T. Shen, X. Li, X. Liu* Materials Chemistry Frontiers, 2024, 8, 2135-2141. Fluorogenic Rhodamine Probes with Pyrrole Substitution Enables STED and Lifetime Imaging of Lysosomes in Live Cells Y. Zhou, Q. Wang, S. Chanmungkalakul, X. Wu, H. Xiao, R. Miao*, X. Liu, Y. Fang Chemistry – A European Journal, 2024, 30, e202303707. Tetrazine-Isonitrile Bioorthogonal Fluorogenic Reactions Enable Multiplex Labeling and Wash-Free Bioimaging of Live Cells Y. Deng, T. Shen, X. Yu, J. Li, P. Zou, Q. Gong, Y. Zheng, H. Sun*, X. Liu*, H. Wu* Angewandte Chemie International Edition, 2024, 63, e202319853. Construction of wavelength-tunable DSE quinoline salt derivatives by regulating the hybridization form of the nitrogen atom and intramolecular torsion angle K. Deng, F. Yang, Z. Cheng, B. Ren, H. Liu, J. Chen, M. She*, L. Yu, X. Liu, H. Feng, J. Li* Chinese Chemical Letters, 2024, 35, 109464. Matthew effect: General design strategy of ultra-fluorogenic nanoprobes with amplified dark–bright states in aggregates S. Segawa, X. Ou, T. Shen, T. Ryu, Y. Ishii, H. H. Y. Sung, I. D. Williams, R. T. K. Kwok, K. Onda, K. Miyata, X. He*, X. Liu*, B. Z. Tang* Aggregate, 2024, 5, e499. Aryl-Modified Pentamethyl Cyanine Dyes at the C2’ Position: A Tunable Platform for Activatable Photosensitizers F. Han, S. A. A. Abedi, S. He, H. Zhang, S. Long, X. Zhou, S. Chanmungkalakul, H. Ma, W. Sun, X. Liu*, J. Du*, J. Fan, X. Peng Advanced Science, 2024, 11, 2305761. Visible light-induced switching of soft matter materials properties based on thioindigo photoswitches S. L. Walden, P. H. D. Nguyen, H. Li, X. Liu, M. T. N. Le, X. J. Loh*, C. Barner-Kowollik* & V. X. Truong* Nature Communications, 2023, 14, 8298. The dark side of cyclooctatetraene (COT): Photophysics in the singlet states of “self-healing” dyes S. Chanmungkalakul, S. A. A. Abedi, F. J. Hernández, J. Xu*, and X. Liu* Chinese Chemical Letters, 2023, 109227. Rational design of supramolecular self-assembly sensor for living cell imaging of HDAC1 and its application in high-throughput screening M. Li, H. Yu, Y. Li, X. Li, S. Huang, X. Liu, G. Weng, L. Xu, T. Hou, D.-S. Guo, Y. Wang* Biosensors and Bioelectronics, 2023, 242, 115716. Recent Advances in Aggregation-Induced Emission (AIE)-Based Chemosensors for the Detection of Organic Small Molecules M. H. Chua*, B. Hui, K. L. O. Chin, Q. Zhu, X. Liu* and J. Xu* Materials Chemistry Frontiers, 2023, 7, 5561. Janus-Type ESIPT Chromophores with Distinctive Intramolecular Hydrogen-bonding Selectivity Y. Chen, S. Lu, S. A. A. Abedi, M. Jeong, H. Li, M. H. Kim, S. Park*, X. Liu*, J. Yoon*, X. Chen* Angewandte Chemie International Edition , 2023, 62, e2023115. Ratiometric quantification and visual detection of sulfur dioxide residues using a coumarin-derived fluorescent probe W. Mi, T. Shen, X. Guo, X. Liu*, M. Zhang*, M. Jia* Sensors and Actuators B: Chemical, 2023, 395, 134459. Blending Low-Frequency Vibrations and Push-pull Effects Affords Superior Photoacoustic Imaging Agents L. Yu, S. A. A. Abedi, J. Lee, Y. Xu, S. Son, W. Chi, M. Li*, X. Liu*, J. H. Park*, J. S. Kim* Angewandte Chemie International Edition, 2023, 62, e2023077. Synergistic effects of multiple rotors and hydrogen-bond interactions lead to sensitive near-infrared viscosity probes for live-cell microscopy D. Li, T. Shen, X. Xue, W. Chen, W. Tao, W. Chi, SH Liu, Y. Tan*, X. Liu*, J. Yin* Science China Chemistry, 2023, 8, 2329–2338. Spontaneously Blinking Rhodamine Dyes for Single-Molecule Localization Microscopy W. Chi, D. Tan, Q. Qiao, Z. Xu*, X. Liu* Angewandte Chemie International Edition, 2023, e202306061. Restriction of Intramolecular Bending (RIB) Enables the Quantitative Design of AIEgens W. Chi, J. Dai, C. Yan, D. Tan, Z. Guo*, X. Liu* Journal of Materials Chemistry C, 2023, 11, 10205. (Editor’s Hot Paper) Visualizing Drug Release from a Stimuli-Responsive Soft Material Based on Amine–Thiol Displacement T. Wu, S. Huang, X. Feng, X. Liu, T. D. James, X. Sun*, X. Qian ACS Applied Materials and Interfaces, 2023, 15, 19, 22967–22976. Modulation of dynamic aggregation in fluorogenic SNAP-tag probes for long-term super-resolution imaging Q. Qiao, W. Liu, W. Chi, J. Chen, W. Zhou, N. Xu, J. Li, X. Fang, Y. Tao, Y. Zhang, Y. Chen, L. Miao, X. Liu, Z. Xu* Aggregate, 2023, 4, e258. Monitoring Amyloid Aggregation via Twisted Intramolecular Charge Transfer (TICT)-Based Fluorescent Sensor Array C. Wang, W. Jiang, D. Tan, Y. Chen, J. Li, Q. Qiao, P. Yadav, X. Liu*, Z. Xu* Chemical Science, 2023, 14, 4786. Ground-State Intramolecular Proton-Transfer Inhibits the Selective Methylation on Quinoline and Pyridine Derivatives S. Chanmungkalakul, S. Huang, X. Wu, E. A. C. Xia, Z. Q. Yang, Y. Li, X. Yan, C. Tan, D. Tan*, X. Liu* Physical Chemistry Chemical Physics, 2023, 25, 10599. 1,2,4,5-Tetrazine-tethered probes for fluorogenically imaging superoxide in live cells with ultrahigh specificity X. Jiang, M. Li, Y. Wang, C. Wang, Y. Wang, T. Shen, L. Shen, X. Liu, Y. Wang,* X. Li* Nature Communications, 2023, 14, 1401. Stepwise On-demand Functionalization of Multihydrosilanes Enabled by a Hydrogen-atom-transfer Photocatalyst Based on Eosin Y X. Fan, M. Zhang, Y. Gao, Q. Zhou, Y. Zhang, J. Yu, W. Xu, J. Yan, H. Liu, Z. Lei, Y. C. Ter, S. Chanmungkalakul, Y. Lum, X. Liu, G. Cui, J. Wu* Nature Chemistry, 2023, 15, 666–676. Shining light on plant health: detecting salt stress with a near-infrared fluorescent probe X. Liu* Advanced Agrochem, 2023, 2, 1-2. Molecular Design of Dual-Emission Rhodamine Analogs X. Wu, Y. Gao, W. Chi, C. Wang, Z. Xu, X. Liu* Materials Chemistry Frontiers, 2023, 7, 1137-1145. The fluorescence quenching mechanism of tetrazine-functionalized fluorogenic labels with integrated π-conjugations: internal conversion to a dark state T. Shen, W. Zhang, P. Yadav, X. W. Sun, X. Liu* Materials Chemistry Frontiers, 2023, 7, 1082-1092. Selective fluorescent sensors for copper(II) ion from julolidine hydrazine derivatives W. Akarasareenon, S. Chanmungkalakul, X. Liu, P. Rashatasakhon* Journal of Photochemistry and Photobiology A: Chemistry, 2023, 437, 114422. A unique NIR dye constructed mitochondrial anchoring fluorescent probe for highly selective selenocysteine detection and imaging in living cells and mice K. Luo, M. Jia, C. Xie, Q. Yang, L. Tan, X. Liu, L. Zhou* Sensors and Actuators B: Chemical, 2023, 375, 132944. Fluorescent Janus ring siloxanes for detection of Au(III) and l-cysteine T. Chaiprasert, S. Chanmungkalakul, Y. Liu, T. Bureerug, K. Silpcharu, M. Unno, X. Liu, V. Ervithayasuporn, Y. Chang*, P. Rashatasakhon* Dyes and Pigments, 2022, 208, 110793. An Approach to Developing Cyanines with Upconverted Photosensitive Efficiency Enhancement for Highly Efficient NIR Tumor Phototheranostics X. Zhao, S. He, W. Chi, X. Liu, P. Chen, W. Sun, J. Du, J. Fan*, X. Peng Advanced Science, 2022, 9, 31, 2202885. Single-Fluorophore-Based Organic Crystals with Distinct Conformers Enabling Wide-Range Excitation-Dependent Emissions R. Huang, C. Wang, D. Tan, K. Wang, B. Zou, Y. Shao, T. Liu, H. Peng*, X. Liu*, Y. Fang* Angewandte Chemie International Edition, 2022, DOI: 10.1002/anie.202211106 Design of an HPPD fluorescent probe and visualization of plant responses to abiotic stress X. Zeng, Y. Huang, J. Dong, X. Ma, J. Nan, W. Chen, H. Lin, W. Yang, X. Liu, J. Yin*, G.Yang* Advanced Agrochem, 2022, DOI: 10.1016/j.aac.2022.08.001 Bronsted Acid-Enhanced Direct Hydrogen Atom Transfer Photocatalysis to Enable Selective Late-Stage Functionalization of Unactivated C(sp3)-H Bonds Cao, H.; Kong, D.; Yang. L.; Chanmungkalakul, S.; Liu, T.; Piper, J. L.; Peng, Z.; Gao, L.; Liu, X.; Hong, X.*, Wu, J.* Nature Synthesis, 2022, DOI: 10.1038/s44160-022-00125-1 “Crossbreeding” Small-Molecular Weight NIR-II Flavchromenes Endows Activatable Multiplexed In Vivo Imaging L. Zhang, Y. Zhang, W. Chi, C. Yan, Z. Zhao, X. Liu, W. Zhu, Z. Guo* ACS Materials Letters, 2022, 4, 1493−1502 Constructing D-π-A-π dye to obtain red-emission fluorescent probe for structured illumination microscopy imaging of lipid droplet dynamics W. Jiang, J. Chen, K. An, P. Bao, Q. Qiao*, X. Liu*, Z. Xu* Green Chemical Engineering, 2022, DOI:10.1016/j.gce.2022.07.002 Modulation of dynamic aggregation in fluorogenic SNAP-tag probes for long-term super-resolution imaging Q. Qiao, W. Liu, W. Chi, J. Chen, W. Zhou, N. Xu, J. Li, X. Fang, Y. Tao, Y. Zhang, Y. Chen, L. Miao, X. Liu, Z. Xu* Aggregate, 2022, DOI:10.1002/agt2.258 High Quantum Yield Blue InP/ZnS/ZnS Quantum Dots Based on Bromine Passivation for Efficient Blue Light-Emitting Diodes W. Zhang, Y. Tan, X. Duan, F. Zhao, H. Liu, W. Chen, P. Liu, X. Liu, K. Wang, Z. Zhang, X. W. Sun* Advanced Optical Materials, 2022, 202200685 Molecular origins of the multi-donor strategy in inducing bathochromic shifts and enlarging Stokes shifts of fluorescent proteins X. Wu, D. Tan, Q. Qiao, W. Yin, Z. Xu*, X. Liu* Physical Chemistry Chemical Physics, 2022, 24, 15937-15944 Rapid quantification of the ethanol content in aqueous solutions using a ratiometric fluorescent sensor T. Shen, D. Tan, M. Shanmughama, X. Liu* Sensors & Diagnostics, 2022, 1, 714–718 A TICS-fluorophore based probe for dual-color GSH imaging W. Liu, J. Chen, Q. Qiao, X. Liu, Z. Xu* Chinese Chemical Letters, 2022, 33, 4943-4947 High-fidelity imaging of amyloid-beta deposits with an ultrasensitive fluorescent probe facilitates the early diagnosis and treatment of Alzheimer’s Disease R. Tao, N. Wang, T. Shen, Y. Tan, Y. Ren, W. Wei, M. Liao, D. Tan, C. Tang, N. Xu, H. Wang*, X. Liu*, X. Li* heranostics, 2022, 12, 2549-2559 Unique assemble of carbonylpyridinium and chromene reveal mitochondrial thiol starvation under ferroptosis and novel ferroptosis inducer K. Ma, H. Yang, T. Shen, Y. Yue, L. Zhao, X. Liu, F. Huo, C. Yin* Chemical Science, 2022, 13, 3706-3712 An Acid-regulated Self-blinking Fluorescent Probe for Resolving Whole-cell Lysosomes with Long-term Nanoscopy Q. Qiao, W. Liu, J. Chen, X. Wu, F. Deng, X. Fang, N. Xu, W. Zhou, S. Wu,W. Yin, X. Liu, Z. Xu* Angewandte Chemie International Edition, 2022, 134, e202202961 (Editor’s Hot Paper) Overcoming the Spectral Dependence: A General Strategy for Developing Far-Red and Near-Infrared Ultra-Fluorogenic Tetrazine Bioorthogonal Probes W. Mao#, W. Chi#, X. He, C. Wang, X. Wang, H. Yang, X. Liu*, H. Wu* Angewandte Chemie International Edition, 2022, 61, e202117386 (#These authors contributed equally to this work; Editor’s Hot Paper) A PET-based Fluorescent Probe for Monitoring Labile Fe(II) Pools in Macrophage Activations and Ferroptosis W. Xing, H. Xu, H. Ma, S. A. A. Abedi, S. Wang, X. Zhang, X. Liu, H. Xu, W. Wang*, K. Lou* Chemical Communications, 2022, 58, 2979-2982 A Descriptor for Accurate Predictions of Host Molecules Enabling Ultralong Room-Temperature Phosphorescence in Guest Emitters S. Chanmungkalakul#, C. Wang#, R. Miao, W. Chi, D. Tan, Q. Qiao, E. C. X. Ang, C. Tan, Y. Fang, Z. Xu*, X. Liu* Angewandte Chemie International Edition, 2022, 134, e202200546 (#These authors contributed equally to this work; Editor’s Hot Paper) Rational Design and Application of An Indolium-Derived Heptamethine Cyanine with Record-Long NIR-II Emission X. Ma, Y. Huang, S. A. A. Abedi, H. Kim, D. Tan, X. Liu, W.C. Yang, Y. Sun, S. H. Liu, J. Yin*, J. Yoon*, G.F. Yang* CCS Chemistry, 2022, 4, 1961-1976 A General Method to Develop Highly Environmentally Sensitive Fluorescent Probes and AIEgens R. Miao, J. Li, C. Wang , X. Jiang, Y. Gao, X. Liu, D. Wang, X. Li, X. Liu*, Y. Fang* Advanced Science, 2022, 9, 2104609 Twisted intramolecular charge transfer (TICT) and twists beyond TICT: from mechanisms to rational designs of bright and sensitive fluorophores C. Wang, W. Chi, Q. Qiao, D. Tan, Z. Xu*, X. Liu* Chemical Society Reviews, 2021, 50, 12656-12678 An Edaravone-Guided Design of a Rhodamine-Based Turn-on Fluorescent Probe for Detecting Hydroxyl Radicals in Living Systems L. Chen, X. Wu, H. Yu, L. Wu, Q. Wang, J. Zhang, X. Liu*, Z. Li, and X. Yang* Analytical Chemistry, 2021, 93, 14343–14350