项瑾 - 武汉大学

个人简介

学习简历： 2001~2006年于武汉大学生命科学学院生物化学及分子生物学专业硕博连读，研究方向结构生物学，运用多种生物化学和结构生物学方法研究小分子-蛋白质相互作用和蛋白质结构功能变化的机制等。 2006年毕业获博士学位。工作简历： 2006~2016年，武汉大学药学院，讲师； 2015~2016年，亚利桑那州立大学，访问学者； 2016年~，武汉大学药学院，副教授。

研究领域

雌激素对乳腺癌细胞自噬的调节机制；雌激素靶标蛋白(包括受体)的结构和功能；药物与蛋白的相互作用；结构基础抗癌新药的发现及相关分子药理学研究。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Jin Xiang, Xiang Liu, Jing Ren, Kun Chen, Hong-lu Wang, Yu-yang Miao & Miao-miao Qi. How does estrogen work on autophagy? Autophagy. 2019, 15, 197-211. (IF11.1, corresponding author) 2. Jin Xiang, Eugene Chun, Chang Liu, Liang Jing, Zina Al-Sahouri, Lan Zhu, Wei Liu. Successful strategies to determine high-resolution structures of GPCRs. Trends in Pharmacological Sciences. 2016, 37:1055-1069. (IF12.797) 3. Jin Xiang, Ying Wang, Ke Su, Min Liu, Peng-Chao Hu, Tian Ma, Jia-Xi Li, Lei Wei, Zhongliang Zheng, Fang Yang, Ritonavir binds to and downregulates estrogen receptors: Molecular mechanism of promoting early atherosclerosis. Experimental Cell Research. 2014, 327: 318-330. 4. Shucai Liang, Yanbin Liu, Jin Xiang, Meng Qin, Hui Yu, Guoping Yan. Fabrication of a new fluorescent polymeric nanoparticle containing naphthalimide and investigation on its interaction with bovine serum albumin. Colloids and Surfaces B: Biointerfaces. 2014, 116: 20-210. 5. Jing-wei Zhang, Ke Su, Wen-tao Shi, Ying Wang, Peng-chao Hu, Yang Wang, Lei Wei, Jin Xiang, Fang Yang, Matrine inhibits the adhesion and migration of BCG823 gastric cancer cells by affecting the structure and function of the vasodilator-stimulated phosphoprotein (VASP). Acta Pharmacologica Sinica. 2013, 34: 1084-1092. (co-corresponding author) 6. Tao Jia, Jin Xiang, Jing Wang, Peng Guo, and Junping Yu. Interactions of newly designed dicationic carbazole derivatives with double-stranded DNA: syntheses, binding studies and AFM imaging. Organic & Biomolecular Chemistry. 2013, 11: 5512-5520. 7. Fanghua Mei, Jin Xiang, Song Han, Yuan He, Yajing Lu, Jian Xu, Deyin Guo, Gengfu Xiao, Po Tien, Guihong Sun, Expression, purification, and secondary structure characterization of recombinant KCTD1. Biochemistry-moscow. 2012, 77: 941-945. (co-first author) 8. Shucai Liang, Hui Yu, Jin Xiang, Wang Yang, Xiaohui Chen, Yanbin Liu, Chen Gao, Guoping Yan. New naphthalimide modified polyethylenimine nanoparticles as fluorescent. Spectrochim Acta A. 2012, 97: 359-365. 9. Tao Huang, Jian Xu, Jin Xiang, Yajing Lu, Rui Chen, Liqin Huang, Gengfu Xiao, Guihong Sun, PrPC interacts with potassium channel tetramerization domain containing 1 (KCTD1) protein through the PrP51-136 region containing octapeptide repeats. Biochemical and Biophysical Research Communications. 2012, 417: 182-186. 10. Jin Xiang, Guihong Sun, Yongxin Mu, Hui Liu, Ying Liu, Fang Yang, Jian Xu, Hong Ding, Ritonavir stimulates foam cell formation by activating PKC. Chemico-Biological Interactions. 2011, 194: 127-133. 11. Ying Liu, Jin Xiang, Min Liu, Shi Wang, Robert J. Lee, and Hong Ding. Protective effects of glycyrrhizic acid by rectal treatment on a TNBS-induced rat colitis model. Journal of Pharmacy and Pharmacology. 2011, 63: 439-446. 12. Min Liu, Jin Xiang, Juan Zhou, and Hong Ding, A disposable amperometric sensor for rapid detection of serotonin in the blood and brain of the depressed mice based on Nafion membrane-coated colloidal gold screen-printed electrode. Journal of Electroanalytical Chemistry. 2010, 640, 1-7. 13. Jin Xiang, Changping Yu, Fang Yang, Ling Yang, Hong Ding, Conformation-activity studies on the interaction of berberine with acetylcholinesterase: Physical chemistry approach. Progress in Natural Science. 2009, 19: 1721-1725. 14. Jin Xiang, Jun-Bao Fan, Nan Chen, Jie Chen, and Yi Liang, Interaction of cellulase with sodium dodecyl sulfate at critical micelle concentration level. Colloids and Surfaces B-Biointerfaces. 2006, 49, 175-180.