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个人简介

学习经历 1985 年 9 月 - 1989 年 7 月,就读于武汉大学生物系微生物学专业,获学士学位。 1989 年 9 月 - 1992 年 7 月,在武汉大学生命科学学院微生物学专业深造,获硕士学位。 1996 年 10 月 - 2001 年 3 月,于日本京都大学大学院工学研究科合成及生物化学专业攻读,获博士学位。 工作经历 1992 年 7 月 - 1996 年 9 月,在武汉大学生命科学学院微生物学系,先后担任助教、讲师。 2001 年 4 月 - 2003 年 8 月,在日本国立产业技术综合研究所生物情报解析研究中心担任博士后(JSPS Fellow)。 2003 年 11 月 - 至今,在武汉大学生命科学学院微生物学系,先后担任副教授、教授。

研究领域

极端古菌分子生物学,重点探讨极端嗜盐、嗜热古菌适应极端环境的分子机理,目前正致力于极端古菌蛋白分泌机制的研究。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

发表的论文(*通讯作者) 1. Huang Q, Zhang K, Li Y, Gan F, Tang XF*, Tang B*. (2022) Auto- and hetero-catalytic processing of the N-terminal propeptide promotes the C-terminal fibronectin type III domain-mediated dimerization of a thermostable Vpr-like protease. Appl Environ Microbiol 88(21):e0150322 2. Mei S, Li M, Sun Y, Deng X, Chen N, Liu Y, Yin J, Luo H, Wu Y, He D, Gan F, Tang B*, Tang XF*. (2022) Sec-dependent secretion of subtilase SptE in haloarchaea facilitates its proper folding and heterocatalytic processing by halolysin SptA extracellularly. Appl Environ Microbiol 88(8):e0024622 3. Zhang K, Huang Q, Li Y, Liu L, Tang XF*, Tang B*. (2022) Maturation process and characterization of a novel thermostable and halotolerant subtilisin-like protease with high collagenolytic activity but low gelatinolytic activity. Appl Environ Microbiol 88(3):e02184-21. 4. Wang J, Hao C, Cao L, Yao Y, Ding Y, Yang Y, Tang XF*, Tang B* (2021) Enhancing extracellular production of recombinant proteins in Escherichia coli by co-expressing with a haloarchaeal protein containing a putative LolA-like domain. Appl Microbiol Biotechnol 105(11):4609-20. 5. Ding Y, Yang Y, Ren Y, Xia J, Liu F, Li Y, Tang XF*, Tang B* (2020). Extracellular production, characterization, and engineering of a polyextremotolerant subtilisin-like protease from feather-degrading Thermoactinomyces vulgaris strain CDF. Front Microbiol 11: 605771. 6. Li B, Liu F, Ren Y, Ding Y, Li Y, Tang XF, Tang B* (2019) Complete genome sequence of Thermoactinomyces vulgaris strain CDF, a thermophilic bacterium capable of degrading chicken feathers. Microbiol Resour Announc 8(28):e00530-19. 7. Li M, Yin J, Mei S, Wang X, Tang XF*,Tang B* (2018) Halolysin SptA, a serine protease, contributes to growth-phase transition of haloarchaeon Natrinema sp. J7-2, and its expression involves cooperative action of multiple cis-regulatory elements. Front Microbiol 9:1799. 8. Perveen S, Rashid N, Tang XF, Imanaka T, Papageorgiou AC* (2017) Anthranilate phosphoribosyltransferase from the hyperthermophilic archaeon Thermococcus kodakarensis shows maximum activity with zinc and forms a unique dimeric structure. FEBS Open Bio 7(8):1217-30. 9. Gao X, Zeng J, Yi H, Zhang F, Tang B*, Tang XF* (2017) Four inserts within the catalytic domain confer extra stability and activity to hyperthermostable pyrolysin from Pyrococcus furiosus. Appl Environ Microbiol 83(5).pii:e03228-16. 10. Zhu F, Yang X, Wu Y, Wang Y, Tang XF, Tang B* (2017) Release of an HtrA-like protease from the cell surface of thermophilic Brevibacillus sp. WF146 via substrate-induced autoprocessing of the N-terminal membrane anchor. Front Microbiol 8:481.

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