蔡国斌 - 武汉大学 - 基础医学院

个人简介

学习经历： 2003.09~2007.06 武汉大学病原生物学专业博士研究生 2000.09~2003.06 武汉大学病原生物学专业硕士研究生 1990.09~1994.06 武汉大学生物学专业大学本科主要工作经历与任职： 2011.03~2012.05 美国贝勒医学院药理学系博士后 2008.12~至今武汉大学基础医学院病原生物学系副教授 2004.03~2006.10 韩国成均馆大学分子寄生虫学系交流学者 1999~2008.11 武汉大学基础医学院病原生物学系讲师 1994.07~1999.11 湖北医科大学基础医学院人体寄生虫学教研室助教

研究领域

（1）寄生虫生殖、生理学研究：重点关注医学吸虫卵胚发育和虫卵形成过程中关键酶的分子特性和动力学研究，以及酶作用的分子机制研究。（2）小分子药物筛选及其抗病原体的机制研究：主要针对病原生物（如疟原虫、弓形虫、结核杆菌等）特有的类异戊二烯合成途径中关键酶的小分子抑制剂进行筛选；同时揭示小分子高效抑制关键酶的分子结构机制，以及其抗病原生物增殖作用的分子机制。

近期论文

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1) Ying Zhang, Jin Guo, Li He, Hong-Ying Zong, Guo-Bin Cai (Correspondence). Isolation and characterization of a novel serine protease inhibitor, SjSPI, from Schistosoma japonicum. Parasitology International 2018, 67(4): 415-424. 2) Ying ZHANG, Young-An BAE, Hong-Ying ZONG, Yoon KONG, Guo-Bin CAI (Correspondence). Functionally Expression of Metalloproteinase in Taenia solium Metacestode and Its Evaluation for Serodiagnosis of Cysticercosis. Iranian Journal of Parasitology 2016, 11(1): 35-45. 3) YING ZHANG, YUAN HE, LI HE, HONGYING ZONG and GUOBIN CAI (Correspondence). Expression and characterization of a phospholipid hydroperoxide glutathione peroxidase gene in Schistosoma japonicum. Parasitology 2015, 142: 1595-1604. 4) Ying Zhang, Yuan He, Li He, Hong-Ying Zong, Guo-Bin Cai (Correspondence). Molecular cloning and characterization of a phospholipid hydroperoxide glutathione peroxidase gene from a blood fluke Schistosoma japonicum. Molecular & Biochemical Parasitology 2015, 203: 5-13. 5) Xue Jian, Diao Jiasheng (Co-first), Guobin Cai (Co-first), Lisheng Deng, Yongcheng Song. Antimalarial and Structural Studies of Pyridine-Containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase. ACS Medicinal Chemistry Letters 2013, 4(2), 278-282. 6) Guobin Cai, Lisheng Deng, Jian Xue, Silvia N.J. Moreno, Boris Striepen, Yongcheng Song. Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Bioorganic & medicinal chemistry letters 2013, 23(7): 2158-2161. 7) Yuan He, Guobin Cai (Co-first), Yonghui Ni, Ying Li, Hongying Zong, Li He. siRNA-mediated knockdown of two tyrosinase genes from Schistosoma japonicum cultured in vitro. Experimental Parasitology 2012, 132: 394-402. 8) Guobin Cai, Lisheng Deng, Bartlomiej G. Fryszczyn, Nicholas G. Brown, Zhen Liu, Hong Jiang, Timothy Palzkill, and Yongcheng Song. Thermodynamic Investigations of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase. ACS Medicinal Chemistry Letters 2012, 3, 496-500. 9) Guo-Bin Cai, Young-An Bae, Seon-Hee Kim, Woon-Mok Sohn, Yoon-Song Lee, Ming-Sen Jiang, Tong-Soo Kim, Yoon Kong. Vitellocyte-specific expression of phospholipid hydroperoxide glutathione peroxidases in Clonorchis sinensis. International Journal for Parasitology 2008, 38: 1613-1623. 10) Guo-Bin Cai, Young-An Bae, Seon-Hee Kim, Byoung-Kuk Na, Tong-Soo Kim, Ming-Sen Jiang, Yoon Kong. A membrane-associated metalloprotease of Taenia solium metacestode structurally related to FACE-1/Ste24p protease family. International Journal for Parasitology 2006, 36: 925-935.