夏宇尘 - 武汉大学 - 基础医学院

个人简介

学习经历： 2008年9月 – 2013年9月博士德国慕尼黑工业大学专业:医学生命科学技术导师: Ulrike Protzer 教授 2005年9月 – 2008年7月硕士中国科学院武汉病毒研究所专业:生物技术与分子生物学导师: 胡志红研究员，邓菲研究员 2001年9月 – 2005年7月本科武汉大学生命科学学院专业:生物技术 7、主要工作经历与任职 2018年3月 – 现在教授，博导病毒学国家重点实验室，基础医学院，武汉大学 2014年10月 – 2018年9月博士后国立糖尿病消化及肾脏疾病研究所，美国国立卫生研究院导师: Dr. T.Jake Liang 2013年9月 – 2014年9月博士后德国环境健康研究中心导师: Ulrike Protzer 教授

个人简介

研究领域

1. 乙肝病毒与宿主相互作用机制； 2. 乙肝病毒致癌机制及靶向治疗； 3. 新型抗病毒药物筛选及机制研究；4. 干细胞精准医疗用于晚期肝病研究。

研究领域

专业：

研究方向：

研究领域和兴趣：

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Yuchen Xia and T.Jake Liang."Development direct acting antivirals and host targeting agents for treatment of HBV infection.".Gastroenterology. 2019 Accepted 2. Yuchen Xia, Xaioming Cheng, Yao Li, Kristin Valdez, Weiping Chen, T.Jake Liang.Hepatitis B virus deregulates cell cycle to promote viral replication and a premalignant phenotype.”Journal of Virology. 2018 Jul 18. pii: JVI.00722-18. doi: 10.1128/JVI.00722-18. 3. Yong Li*, Yuchen Xia*, Meifang Han, Guang Chen, Dake Zhang, Wolfgang E. Thasler, Ulrike Protzer, Qin Ning.“IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection.”Scientific Reports. 2017 Oct 5;7(1):12715. doi: 10.1038/s41598-017-13082-z. (共同第一作者) 4. Xiaoming Cheng, Yuchen Xia, Elisavet Serti, Peter Daniel Block, Michelle Chung, Kazuaki Chayama, Barbara Rehermann, T. Jake Liang.“Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages.”Hepatology. 2017 Dec;66(6):1779-1793. 5. Yuchen Xia, Xiaoming Cheng, Christoph K. Blossey, Karin Wisskirchen, Knud Esser, Ulrike Protzer “Secreted interferon-inducible factors restrict hepatitis B and C virus entry in vitro.”Journal of Immunology Research, 2017, doi: 10.1155/2017/4828936 6. Yuchen Xia and Ulrike Protzer.“Control of Hepatitis B Virus by Cytokines.”Viruses 2017, 9(1), 18; doi: 10.3390/v9010018 7. Yuchen Xia, Daniela Stadler, Chunkyu Ko, Ulrike Protzer. “Analyses of HBV cccDNA Quantification and Modification.”Methods Mol Biol. 2017;1540:59-72. 8. Yuchen Xia, Arnaud Carpentier, Xiaoming Cheng, Peter Daniel Block, Yao Zhao, Zhensheng Zhang, Ulrike Protzer, T. Jake Liang. “Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions.“Journal of Hepatology. 2016 Oct 13. pii: S0168-8278(16)30572-4. 9. Arnaud Carpentier, Ila Nimgaonkar, Virginia Chu, Yuchen Xia, Zongyi Hu, T. Jake Liang, “Hepatic differentiation of human pluripotent stem cells in miniaturized format suitable for high-throughput screen.”Stem Cell Res. 2016 Mar 29;16(3):640-650. 10. Yuchen Xia*, Daniela Stadler*, Julie Lucifora, Florian Reisinger, Dennis Webb, Marianna Hösel, Thomas Michler, Karin Wisskirchen, Xiaoming Cheng, Ke Zhang,Wen-Min Chou, Jochen M. Wettengel, Antje Malo, Felix Bohne, Dieter Hoffmann, Florian Eyer, Robert Thimme, Christine S. Falk, Wolfgang E.Thasler,Mathias Heikenwälder, Ulrike Protzer.“Interferon-γ and Tumor Necrosis Factor-α Produced by T cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis”Gastroenterology. 2016;150:194-205. 11. Julie Lucifora*, Yuchen Xia*, Florian Reisinger, Daniela Stadler, Mathias Heikenwälder, Ulrike Protzer.“Specific degradation of nuclear hepatitis B virus covalently closed circular DNA.”Medecine sciences: M/S 08/2014; 30(8-9):724-726. 12. Yuchen Xia, Julie Lucifora, Florian Reisinger, Mathias Heikenwalder, Ulrike Protzer.“Response to Comment on Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA ”Science. 2014, Vol. 344 no. 6189 pp. 1237 13. Lucifora J*, Xia Y*, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U. “Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA.”Science. 2014, Vol. 343 no. 6176 pp. 1221-1228. (共同第一作者) 14. Forough Golsaz Shirazi, Hamed Mohammadi, Mohammad Mehdi Amiri, Katrin Singethan, Yuchen Xia, Ali Ahmad Bayat, Motahareh Bahadori, Hodjatallah Rabbani, Mahmood Jeddi –Tehrani, Ulrike Protzer, Fazel Shokri. “Monoclonal antibodies to various epitopes of HBs antigen inhibit HBV infection.”Journal of Gastroenterology and Hepatology. 2014 May;29(5):1083-91.

近期论文

1. Yuchen Xia and T.Jake Liang."Development direct acting antivirals and host targeting agents for treatment of HBV infection.".Gastroenterology. 2019 Accepted   2. Yuchen Xia, Xaioming Cheng, Yao Li, Kristin Valdez, Weiping Chen, T.Jake Liang.Hepatitis B virus deregulates cell cycle to promote viral replication and a premalignant phenotype.”Journal of Virology. 2018 Jul 18. pii: JVI.00722-18. doi: 10.1128/JVI.00722-18.   3. Yong Li*, Yuchen Xia*, Meifang Han, Guang Chen, Dake Zhang, Wolfgang E. Thasler, Ulrike Protzer, Qin Ning.“IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection.”Scientific Reports. 2017 Oct 5;7(1):12715. doi: 10.1038/s41598-017-13082-z. (共同第一作者)   4. Xiaoming Cheng, Yuchen Xia, Elisavet Serti, Peter Daniel Block, Michelle Chung, Kazuaki Chayama, Barbara Rehermann, T. Jake Liang.“Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages.”Hepatology. 2017 Dec;66(6):1779-1793.   5. Yuchen Xia, Xiaoming Cheng, Christoph K. Blossey, Karin Wisskirchen, Knud Esser, Ulrike Protzer “Secreted interferon-inducible factors restrict hepatitis B and C virus entry in vitro.”Journal of Immunology Research, 2017, doi: 10.1155/2017/4828936   6. Yuchen Xia and Ulrike Protzer.“Control of Hepatitis B Virus by Cytokines.”Viruses 2017, 9(1), 18; doi: 10.3390/v9010018   7. Yuchen Xia, Daniela Stadler, Chunkyu Ko, Ulrike Protzer. “Analyses of HBV cccDNA Quantification and Modification.”Methods Mol Biol. 2017;1540:59-72.   8. Yuchen Xia, Arnaud Carpentier, Xiaoming Cheng, Peter Daniel Block, Yao Zhao, Zhensheng Zhang, Ulrike Protzer, T. Jake Liang. “Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions.“Journal of Hepatology. 2016 Oct 13. pii: S0168-8278(16)30572-4.   9. Arnaud Carpentier,  Ila Nimgaonkar, Virginia Chu, Yuchen Xia, Zongyi Hu, T. Jake Liang, “Hepatic differentiation of human pluripotent stem cells in miniaturized format suitable for high-throughput screen.”Stem Cell Res. 2016 Mar 29;16(3):640-650.   10. Yuchen Xia*, Daniela Stadler*, Julie Lucifora, Florian Reisinger, Dennis Webb, Marianna Hösel, Thomas Michler, Karin Wisskirchen, Xiaoming Cheng, Ke Zhang,Wen-Min Chou, Jochen M. Wettengel, Antje Malo, Felix Bohne, Dieter Hoffmann, Florian Eyer, Robert Thimme, Christine S. Falk, Wolfgang E.Thasler,Mathias Heikenwälder, Ulrike Protzer.“Interferon-γ and Tumor Necrosis Factor-α Produced by T cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis”Gastroenterology. 2016;150:194-205.   11. Julie Lucifora*, Yuchen Xia*, Florian Reisinger, Daniela Stadler, Mathias Heikenwälder, Ulrike Protzer.“Specific degradation of nuclear hepatitis B virus covalently closed circular DNA.”Medecine sciences: M/S 08/2014; 30(8-9):724-726.   12. Yuchen Xia, Julie Lucifora, Florian Reisinger, Mathias Heikenwalder, Ulrike Protzer.“Response to Comment on Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA ”Science. 2014, Vol. 344 no. 6189 pp. 1237   13. Lucifora J*, Xia Y*, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U.  “Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA.”Science. 2014, Vol. 343 no. 6176 pp. 1221-1228. (共同第一作者)   14. Forough Golsaz Shirazi, Hamed Mohammadi, Mohammad Mehdi Amiri, Katrin Singethan, Yuchen Xia, Ali Ahmad Bayat, Motahareh Bahadori, Hodjatallah Rabbani, Mahmood Jeddi –Tehrani, Ulrike Protzer, Fazel Shokri. “Monoclonal antibodies to various epitopes of HBs antigen inhibit HBV infection.”Journal of Gastroenterology and Hepatology. 2014 May;29(5):1083-91.