个人简介
Education
Sep 2007 – Jul 2012 Tsinghua University, China Ph.D.
Sep 2003 – Jul 2007 Nankai University, China B.S.
Working Experience
Jan 2018 – Now Wuhan University, China Professor
Aug 2013 – Dec 2017 Duke University, U.S.A. Postdoc
Jul 2012 – Jul 2013 Tsinghua University, China Postdoc
Oct 2010 – Jul 2013 Tsinghua University, China College Counselor
研究领域
Research Interests:
Our Biotechnology & Interdisciplinary Research Lab aims to use interdisciplinary strategy to study Translational Control, Plant Defense and Precision Agriculture.
We are focusing on two basic biological questions. One is the Bio-triangle relationship (i.e., plant-pathogen-endophyte). Overusing pesticides and fertilizers and gaining resistant traits must ruin the harmonious bio-triangle relationship. We are working on the molecular mechanisms of the Arabidopsis-Pseudomonas-entophytic bacteria bio-triangle interaction model to help engineer disease-resistant crops. The other question is the Trait-triangle relationship (i.e., defense-yield-quality). High yield usually compromises crop defense and quality. We are working on the molecular mechanisms of balancing the trait-triangle relationship to meet the increasing requirement for high-quality crops.
To address those questions, we are developing novel Biotechniques by introducing different disciplines, including omics and information technology, microfluidic technology, synthetic chemistry and biology.
近期论文
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Published Papers(# Co-first author; *Corresponding):
Corresponding and co-corresponding:
7. Yulu Zhou, Ruixia Niu, Zhijuan Tang, Rui Mou, Zhao Wang, Sitao Zhu, Hongchun Yang, Pingtao Ding and Guoyong Xu*: Plant HEM1 specifies a condensation domain to control immune gene translation. Nature Plants 01/23, DOI: 10.1038/s41477-023-01355-7
6. Tianyuan Chen, Guoyong Xu#*, Rui Mou, George H. Greene, Lijing Liu, Jonathan Motley and Xinnian Dong*: Global translational induction during NLR-mediated immunity in plants is dynamically regulated by CDC123, an ATP-sensitive protein. Cell Host and Microbe 01/23, DOI: 10.1016/j.chom.2023.01.014
5. Yin Zhao, Dongjuan Chen, Zhichen Xu, Tao Li, Jiang Zhu, Rui Hu, Guoyong Xu*, Ying Li*, Yunhuang Yang*, Maili Liu*: Integrating CRISPR-Cas12a into a microfluidic dual-droplet device enables simultaneous detection of HPV16 and HPV18.Analytical Chemistry 01/23, DOI: 10.1021/acs.analchem.2c05320
4. Guilong Zhou, Ruixia Niu, Yulu Zhou, Ming Luo, Yao Peng, Hui Wang, Zhao Wang, Guoyong Xu*: Proximity editing to identify RNAs in phase-separated RNA binding protein condensates. Cell Discovery 03/2021, DOI: 10.1038/s41421-021-00288-9
3. Ruixia Niu, Yulu Zhou, Yu Zhang, Rui Mou, Zhijuan Tang, Zhao Wang, Guilong Zhou, Sibin Guo, Meng Yuan, Guoyong Xu*: uORFlight: a vehicle toward uORF-mediated translational regulation mechanisms in eukaryotes. Database 03/2020, DOI: 10.1093/database/baaa007
2. Jingjing Tian,Guoyong Xu*, Meng Yuan*: Towards engineering broad-spectrum disease-resistant crops. Trends in Plant Science 02/2020, DOI: 10.1016/j.tplants.2020.02.012 (Note: Spotlight)
1. Jingjing Tian,Guoyong Xu*, Meng Yuan*: Precise editing enables crop broad-spectrum resistance. Molecular Plant 11/2019, DOI: 10.1016/j.molp.2019.11.006 (Note: Spotlight)
First and co-first:
7. Shanshan Wang#, Ke Xie#, Guoyong Xu#, Huarui Zhou, Qiang Guo, Jingyi Wu, Zengwei Liao, Na Liu, Yan Wang, Yule Liu: Plant G proteins interact with ER luminal protein receptors to regulate ER retrieval: Signaling between ERD2s and G proteins. Journal of Integrative Plant Biology03/2018, DOI: 10.1111/jipb.12648
6. Guoyong Xu#, George H. Greene#, Heejin Yoo#, Lijing Liu, Jorge Marqués, Jonathan Motley, Xinnian Dong: Global translational reprogramming is a fundamental layer of immune regulation in plants. Nature 04/17, DOI: 10.1038/nature22371
5. Guoyong Xu#, Meng Yuan#, Chaoren Ai, Lijing Liu, Edward Zhuang, Sargis Karapetyan, Shiping Wang, Xinnian Dong: uORF-mediated translation allows engineered plant disease resistance without fitness cost. Nature 04/17, DOI: 10.1038/nature22372
4. Guoyong Xu#, Shanshan Wang#, Shaojie Han, Ke Xie, Yan Wang, Jinlin Li, Yule Liu: Plant Bax Inhibitor-1 interacts with ATG6 to regulate autophagy and programmed cell death. Autophagy 07/2017, DOI: 10.1080/15548627.2017.1320633
3. Guoyong Xu#, Yule Liu: Plant ERD2s self-interact and interact with GTPase-activating proteins and ADP-ribosylation factor 1. Plant signaling & behavior 09/2012, DOI: 10.4161/psb.21217
2. Guoyong Xu#, Sizhun Li#, Ke Xie, Qiang Zhang, Yan Wang, Yang Tang, Dong Liu, Yiguo Hong, Chenyang He, Yule Liu: Plant ERD2-like proteins function as ER luminal protein receptors and participate in programmed cell death during innate immunity. The Plant Journal 05/2012, DOI: 10.1111/j.1365-313X.2012.05053.x
1. Guoyong Xu#, Ning Sui#, Yang Tang, Ke Xie, Yizhen Lai, Yule Liu: One-step, zero-background ligation-independent cloning intron-containing hairpin RNA constructs for RNAi in plants. New Phytologist 07/2010, DOI: 10.1111/j.1469-8137.2010.03253.x
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