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个人简介

教授,博士生导师。主要从事合成生物、系统生物学、生物医用材料等领域的研究。至今在 Chemical Engineering Journal 、 Small Structure 、 mBio 、 Nanoscale 、 Biotechnology for Biofuels 等杂志发表 SCI 论文 55 篇,其中通讯 / 一作 45 篇,发表文章总引用次数 2200 多次。授权专利 11 项。主持国家自然科学青年基金和面上项目基金。参与 973 、 863等重大科技项目多项。目前的主要研究方向有 ( 1 )微生物蛋白质的机理研究和应用;( 2 )生物质碳点的合成和应用;( 3 )抗菌抗癌纳米药物研发。 工作教育经历 : 2023/5- 至今, 东南大学, 生医学院, 教授 2014/9-2023/4 , 东南大学, 生医学院, 副教授 2011/9-2014/8, 美国密歇根大学,化工系和化学系,博士后 2005/9-2011/6 ,天津大学, 制药工程, 博士,元英进 2009/9-2011/6 ,美国密歇根大学, 化学工程系, 联合培养 ,Xiaoxia Nina Lin 2001/9-2005/9 ,天津大学, 制药工程, 学士

研究领域

( 1 )微生物蛋白质的机理研究和应用 ( 2 )生物质碳点的合成和应用 ( 3 )抗菌抗癌纳米药物研发

近期论文

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(1)S amran Durrani, Jie Zhang, Faisal Durrani, Zihao Wang , Mukramin, Ke-Fei Xu, Haiyan Wang, Haroon Khan, Fu-Gen Wu, Fengming Lin* . Triple channel fluorescence Na-Ca-Cl-doped carbon dots for erythrosine detection in food samples and living cells. Journal of Molecular Structure, 2025, 139934. (IF: 4.9; 2 区 ) (2)Haiyan Wang, Xiaotong Shi, Liujie Huo, Jing Tu, Chengcheng Li, Fu-Gen Wu, Fengming Lin* . The discovery of novel ER-localized cellobiose transporters involved in cellulase biosynthesis in Trichoderma reesei . Journal of Basic Microbiology, 2024, e2400573. (IF: 3.5; 4 区 ) (3) Jie Zhang, Barbar Khan, Funing Zhang, Samran Durrani, Fu-Gem Wu, Fengming Lin* . Natural outer membrane vesicles from  Serratia marcescens  for inherent and biocompatible anti-microbial photodynamic therapy. Chemical Engineering Journal,  2024,502. (IF: 13.4; 1 区 ) (4)Babar Khan, Jie Zhang, Samran Durrani, Haiyan Wang, Ali Nawaz, Faisal Durrani, Yonghao Ye, Fu-Gen Wu, Fengming Lin*. Carbon-dots-mediated improvement of antimicrobial activity of natural products. ACS Applied Materials & Interfaces 2024, 16, 47257−47269. (IF: 8.5; 2 区 ) (5)Ai-Ping Pang , Haiyan Wang, Yongsheng Luo, Funing Zhang, Fu-Gen Wu , Zhihua Zhou, Zuhong Lu * , Fengming Lin* . Investigating the cellular functions of ?-glucosidases for synthesis of lignocellulose-degrading enzymes in Trichoderma reesei , Engineering Microbiology, 2023, 3, 1005. (6)Haiyan Wang, Ai-Ping Pang, Bingzhi Li, Liujie Huo, Fu-Gen Wu, Fengming Lin * . Intracellular sugar transporters facilitate cellulase synthesis in Trichoderma reesei using lactose. Biomolecules, 2023, 13, 295. (IF: 5.5; 2 区 ) (7)Zihuayuan Yang, Jie Zhang, Fu-Gen Wu, Fengming Lin *. Structural characterization, functional profiling, and mechanism study of four antimicrobial peptides for antibacterial and anticancer applications. Langmuir 2023, 39, 2161−2170. (3.9; 3 区 ) (8)Samran Durrani, Jie Zhang, Mukramin, Haiyan Wang, Zihao Wang, Latif Ullah Khan, Funing Zhang, Faisal Durrani, Fu-Gen Wu, and Fengming Lin *. Biomass-based carbon dots for Fe 3+ and adenosine triphosphate detection in mitochondria. ACS Applied Nano Materials, 2023, 6, 1, 76–85. (IF: 5.9; 2 区 ) (9)Samran Durrani, Zihuayuan Yang, Jie Zhang, Zihao Wang, Haiyan Wang, Faran Durrani, Fu-Gen Wu, Fengming Lin* . Nucleus-targeting pH-responsive carbon dots for fast nucleus pH detection. Talanta, 2023, 152:123855. (IF: 6.5; 2 区 ) (10)Zihuayuan Yang, Xin Hu, Funing Zhang, Samran Durrani, Jie Zhang, Ai-Ping Pang, Yichen Gao, Fu-Gen Wu, Fengming Lin *. Chitosan-modified fluorescent dye for simple, fast, and in-situ measurement of fungal cell growth in the presence of insoluble compounds. FEMS Microbiology Letters , 2022, 369,1, fnac118. (IF: 2.8; 4 区 ) (11)Haiyan Wang, Ai-Ping Pang, Wei Wang, Bingzhi Li, Chengcheng Li, Fu-Gen Wu, Fengming Lin* . Discovery of ER-localized sugar transporters for cellulase production with lac1 being essential. Biotechnology for Biofuels and Bioproducts, 2022, 15: 132. (IF: 7.7; 1 区 ) (12)Jie Zhang, Funing Zhang, Xin Hu, Jing Yang, Haiyan Wang, Samran Durrani, Fu-Gen Wu, Fengming Lin* . Self-assembly and disassembly of glycol chitosan/photosensitizer nano-micelles for antibacterial photodynamic therapy. ACS Applied Polymer Materials, 2022, 4, 8665−867. (IF: 4.8; 2 区 ) (13) Fengming Lin , Chenyang Jia, and Fu-Gen Wu*. Intracellular enzyme-instructed self-assembly of peptides (IEISAP) for biomedical applications. Molecules, 2022, 27, 6557. (IF: 4.9; 2 区 ) (14) Fengming Lin , Zihao Wang and Fu-Gen Wu*. Carbon dots for killing microorganisms: An update since 2019. Pharmaceuticals, 2022, 15, 1236. (IF: 5.2; 2 区 ) (15)Chengcheng Li, Ruihan Gu, Fengming Lin* , Huining Xiao *. Sorbicillinoids hyperproduction without affecting the cellulosic enzyme production in Trichoderma reesei JNTR5. Biotechnology for Biofuels, 2022, 15: 85. (IF: 7.7; 1 区 ) (16) Fengming Lin , Cheyang Jia, Fu-Gen Wu *, Carbon dots for intracellular sensing. Small Structures, 2022, 3, 2200033. (IF: 11.3) (17)Ai-Ping Pang, Yongsheng Luo, Xin Hu, Funing Zhang, Haiyan Wang, Yichen Gao, Samran Durrani, Chengcheng Li, Xiaotong Shi, Fu-Gen Wu, Bing-Zhi Li, Zuhong Lu * , Fengming Lin*. Transmembrane transport process and endoplasmic reticulum function facilitate the role of gene cel1b in cellulase production of Trichoderma reesei. Microbial Cell Factories, 2022. (IF: 6.4; 2 区 ) (18)Yichen Gao, Ai-Ping Pang, Leyao Ma, Haiyan Wang, Samran Durrani, Bingzhi Li, Fu-Gen Wu, Fengming Lin*. Intron retention coupled with nonsense-mediated decay is involved in cellulase biosynthesis in cellulolytic fungi. Biotechnology for Biofuels, 2022, 15: 53. (IF:7.7; 1 区 ) (19)Samran Durrani, Jie Zhang , Ai-Ping Pang, Yichen Gao, Tian-Yu Wang, Haiyan Wang , Fu-Gen Wu, Fengming Lin* . Carbon dots for multicolor cell imaging and ultra-sensitive detection of multiple ions in living cells: one stone for multiple birds. Environmental Research, 2022, 212:1113260 (IF: 8.4; 2 区 ) (20)Samran Durrani, Jie Zhang , Zihuayuan Yang, Ai-Ping Pang, Jia Zeng, Sayed Mir Sayed, Adeel Khan, Yaqin Zhang, Fu-Gen Wu, Fengming Lin* . Plant-derived Ca, N, S-Doped carbon dots for fast universal cell imaging and intracellular Congo red detection. Analytica Chimica Acta, 2022, 339672. (IF: 6.9; 1 区 ) (21)Jie Zhang, Zihuayuan Yang, Yan-Hong Li, Samran Durrani, Ai-Ping Pang, Yichen Gao, Fu-Gen Wu, Fengming Lin*. Super stable chitosan-based nanoparticles for broad-spectrum antimicrobial photodynamic therapy. ACS Applied Polymer Materials, 2022, 4:425–434. (IF: 4.8; 2 区 ) (22)Ai-Ping Pang, Funing Zhang, Xin Hu, Yongsheng Luo, Haiyan Wang, Samran Durrani, Fu-Gen Wu, Bing-Zhi Li, Zhihua Zhou, Zuhong Lu * , Fengming Lin * . Glutamine involvement in nitrogen regulation of cellulase production in fungi. Biotechnology for Biofuels, 2021, 14:199. (IF: 7.7; 1 区 ) (23)Ai-Ping Pang, Haiyan Wang, Funing Zhang, Xin Hu, Fu-Gen Wu, Zhihua Zhou, Wei Wang, Zuhong Lu*, Fengming Lin* . High-dose rapamycin exerts a temporary impact on T. reesei RUT-C30 through gene trFKBP12. Biotechnology for Biofuels, 2021, 14:77. (IF: 7.7; 1 区 ) (24)Ai-Ping Pang, Haiyan Wang, Yongsheng Luo, Zihuayuan Yang, Zhiyu Liu, Zhao Wang, Bingzhi Li, Song Yang, Zhihua Zhou, Xiaolin Lu, Fu-Gen Wu, Zuhong Lu*, Fengming Lin* . Dissecting cellular function and distribution of β-glucosidases in Trichoderma reesei . mBio, 2021, 12(3):e03671-20. (IF: 7.8; 1 区 ) (25) Fengming Lin , Qiu-Yi Duan, and Fu-Gen Wu * . Conjugated Polymer-Based Photothermal Therapy for Killing Microorganisms. ACS Applied Polymer Materials, 2020, 2, 4331−4344 . (IF: 4.8; 2 区 ) (26)Zihuayuan Yang, Ying Qiao, Junying Li, Fu-Gen Wu, Fengming Lin* . Novel Water-Soluble Photosensitizer from Trichoderma reesei for photodynamic inactivation of gram-positive bacteria. Langmuir, 2020, 36: 13227–13235. (IF: 4.3; 2 区 ) (27)Liang Ma, Ai‑Ping Pang, Yongsheng Luo, Xiaolin Lu* and Fengming Lin *. Beneficial factors for biomineralization by ureolytic bacterium Sporosarcina pasteurii. Microbial Cell Factory, 2020, 19:12. (IF: 5.3; 2 区 ) (28)Chengcheng Li, Ai-Ping Pang, Hang Yang, Rongjin Lv, Zhihua Zhou, Fu-Gen Wu, Fengming Lin *. Tracking localization and secretion of cellulase spatiotemporally and directly in living Trichoderma reesei . Biotechnology for biofuels, 2019,12, 200. (IF: 7.7; 2 区 ) (29) Fengming Lin , Hao-Ran Jia, and Fu-Gen Wu. Glycol chitosan: A water-soluble polymer for cell imaging and drug delivery. Molecules 24.23 (2019): 4371. (IF: 4.9; 3 区 ) (30) Fengming Lin , Yan-Wen Bao, and Fu-Gen Wu. Carbon Dots for Sensing and Killing Microorganisms. C-Journal of Carbon Research, 2019, 5: 33. (31)Chengcheng Li, Fengming Lin *, Wei Sun, Shaoxun Yuan, Zhihua Zhou, Fu‑Gen Wu and Zhan Chen. Constitutive hyperproduction of sorbicillinoids in Trichoderma reesei ZC121. Biotechnology for Biofuels, 2018, 11:291. (IF: 7.7; 1 区 ) (32) Fengming Lin , Yan-Wen Bao and Fu-Gen Wu. Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria. Molecules, 2018, 23, 3016. (IF: 4.9; 3 区 ) (33) Fengming Lin *, Chengcheng Li, and Zhan Chen. Exopolysaccharide-Derived Carbon Dots for Microbial Viability Assessment. Frontiers in Microbiology. 2018, 9. 2697. (IF: 5.0; 2 区 ) (34)Chengcheng Li, Fengming Lin *, Wei Sun, Fu-Gen Wu, Hang Yang, Roujing Lv, Ya-Xuan Zhu, Hao-Ran Jia, Chu Wang, Ge Gao, Zhan Chen. Self-assembled rose bengal-exopolysaccharide nanoparticles for improved photodynamic inactivation of bacteria by enhancing singlet oxygen generation directly in the solution. ACS Applied Materials & Interfaces, 2018, 10(19), 16715-16722 (IF: 10.4; 1 区 ) (35) Fengming Lin *, Chengcheng Li, Zhan Chen. Bacteria-derived carbon dots inhibit biofilm formation of Escherichia coli without affecting cell growth. 2018, Frontiers in Microbiology, 2018, 9, 259. (IF: 5.0; 2 区 ) (36)Chengcheng Li, Fengming Lin *, Le Zhou, Lei Qin, Bingzhi Li, Zhihua Zhou, Mingjie Jin, Zhan Chen. Cellulase hyper-production by Trichoderma reesei mutant SEU-7 on lactose. Biotechnology for Biofuels , 2017, 10, 228. (IF: 7.7; 1 区 ) (37) Fengming Lin *, Chengcheng Li, Li Dong, Degang Fu, and Zhan Chen * . Imaging biofilm-encased microorganisms using carbon dots derived from L. plantarum . Nanoscale , 2017, 9, 9056-9064. (IF: 8.3; 1 区 ) (38)Chengcheng Li, Le Zhou, Hang Yang, Roujing Lv, Peilong Tian, Xu Li, Yaqin Zhang, Zhan Chen * , Fengming Lin *. Self-assembled Exopolysaccharide Nanoparticles for Bioremediation and Green Synthesis of Noble Metal Nanoparticle s. ACS Applied Materials & Interfaces, 2017,9, 22808−22818. (IF: 10.4; 1 区 ) . (39)Chengcheng Li, Fengming Lin *, Yizhen Li, Wei Wei, Hongyin Wang, Lei Qin, Zhihua Zhou, Bingzhi Li, Fugen Wu, Zhan Chen, A beta-glucosidase hyper-production Trichoderma reesei mutant reveals a potential role of cel3D in cellulose production. Microbial Cell Factories , 2016 , 15 ( 1 ): 151. (IF:6.4; 2 区 ) (40) Fengming Lin , Kyle L. Fergusion, David R. Boyer, Xiaoxia Nina Lin, E. Neil G. Marsh . Isofunctional enzymes PAD1 and UbiX catalyze formation of a novel cofactor required by Ferulic Acid Decarboxylase and 4-Hydroxy-3-polyprenylbenzoic Acid Decarboxylase. ACS Chemical Biology , 2015, 10, 1137-1144. (IF: 4.6; 2 区 ) (41) Fengming Lin , E. Neil G. Marsh, Xiaoxia Nina Lin . Recent progress in hydrocarbon biofuel synthesis: pathways and enzymes . Chinese Chemical Letters , 2015, 26, 431-434. (IF: 8.5; 2 区 ) (42) Fengming Lin , Yu Chen, Robert Levine, Kilho Lee, Yingjin Yuan, Xiaoxia Nina Lin . Improving fatty acid availability for bio-hydrocarbon production in Escherichia coli by metabolic engineering . PLoS One , 2013, 8(10): e78595. (IF: 3.7; 3 区 ) (43) Fengming Lin , Debasis Das, Xiaoxia Nina Lin, E. Neil G. Marsh . Aldehyde-forming fatty acyl-CoA reductase from cyanobacteria: expression, purification and characterization of the recombinant enzyme . FEBS Journal , 2013, 280:4773-4781. (IF:5.6; 2 区 ) (44) Fengming Lin , Ying Tan, Ying-jin Yuan . Temperal quantitative proteomics of Saccharomyces cerevisiae in response to a nonlethal concentration of furfural . Proteomics , 2009, 9:5471-5483. (IF:5.4; 2 区 ) (45) Fengming Lin , Bin Qiao, Ying-jin Yuan . Comparative proteomic analysis of tolerance and adaptation of ethanologenic Saccharomyces cerevisiae to furfural , a lignocellulosic inhibitory compound . Applied and Environmental Microbiology , 2009, 75(1):3765-3776. (IF:5.0; 2 区 )

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