Kosik, Kenneth S - University of California, Santa Barbara - Biomolecular Science and Engineering

个人简介

Kenneth S. Kosik completed a B.A. and M.A. in English literature from Case Western Reserve University in 1972 and an M.D. from the Medical College of Pennsylvania in 1976. He served as a resident in neurology at Tufts New England Medical Center and was Chief Resident there in 1980. Beginning in 1980 he held a series of academic appointments at the Harvard Medical School and achieved the rank of full professor there in 1996. He also held appointments at McLean Hospital, Brigham and Women's Hospital, the Massachusetts General Hospital and the Dana-Farber Cancer Institute. In 2004, Kosik became the Harriman Professor of Neuroscience Research and Co-Director of the Neuroscience Research Institute at the University of California, Santa Barbara. He founded and serves as Medical Director of the non-profit center, Cottage Center for Brain Fitness (CCBF).

研究领域

The Kosik lab intends to create an intellectual setting conducive to the exploration of fundamental biological processes, particularly those related to the brain and its evolution. Although the approach is largely reductionist with an emphasis on genes, molecules and cells, studies in the lab also encompass systems level informatic approaches that include large genomic and transcriptional and imaging data sets. One theme in the lab is how cells acquire and lose their identities. A specialized case of altered cellular identity is synaptic plasticity. The lab is interested in the underlying molecular basis of plasticity, particularly how protein translation at the synapse affects learning and how impairments of plasticity lead to neurodegenerative diseases. Behind all the lab projects stands the overarching principle succinctly stated by Theodosius Dobzhansky, "Nothing in Biology Makes Sense Except in the Light of Evolution."

近期论文

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Life at Low Copy Number: How Dendrites Manage with So Few mRNAs. Kosik KS. Neuron. 2016 Dec 21;92(6):1168-1180. doi: 10.1016/j.neuron.2016.11.002. Review.PubMed PMID: 28009273. Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability. Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MH, Zhang Z, Huang Y,Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ. Stem Cell Reports. 2016 Sep 13;7(3):325-40. doi: 10.1016/j.stemcr.2016.08.001. PubMed PMID:27594585; PubMed Central PMCID: PMC5032560. A path toward understanding neurodegeneration. Kosik KS, Sejnowski TJ, Raichle ME, Ciechanover A, Baltimore D. Science. 2016 Aug 26;353(6302):872-3. doi:10.1126/science.aai7622. PubMed PMID: 27563087. A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA. Rani N, Nowakowski TJ, Zhou H, Godshalk SE, Lisi V, Kriegstein AR, Kosik KS. Neuron. 2016 Jun 15;90(6):1174-88. doi:10.1016/j.neuron.2016.05.005. PubMed PMID: 27263970; PubMed Central PMCID:PMC4911262. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V,Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Neuron. 2016 May 4;90(3):662. doi:10.1016/j.neuron.2016.04.025. PubMed PMID: 27151643. Primary Cilium-Autophagy-Nrf2 (PAN) Axis Activation Commits Human Embryonic Stem Cells to a Neuroectoderm Fate. Jang J, Wang Y, Lalli MA, Guzman E, Godshalk SE, Zhou H, Kosik KS. Cell. 2016 Apr 7;165(2):410-20. doi:10.1016/j.cell.2016.02.014. PubMed PMID: 27020754. Tracking Down Mutations Cell by Cell. Kosik KS. Neuron. 2016 Mar 16;89(6):1126-7. doi: 10.1016/j.neuron.2016.02.042. PubMed PMID: 26985720. Detection of Prokaryotic Genes in the Amphimedon queenslandica Genome. Conaco C, Tsoulfas P, Sakarya O, Dolan A, Werren J, Kosik KS. PLoS One. 2016 Mar 9;11(3):e0151092. doi: 10.1371/journal.pone.0151092. PubMed PMID: 26959231; PubMed Central PMCID: PMC4784904. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Piedrahita D, Castro-Alvarez JF, Boudreau RL, Villegas-Lanau A, Kosik KS, Gallego-Gomez JC, Cardona-Gómez GP. Front Cell Neurosci. 2016 Jan 8;9:498. doi: 10.3389/fncel.2015.00498. PubMed PMID: 26778963; PubMed Central PMCID: PMC4705306. Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways. Lalli MA, Jang J, Park JH, Wang Y, Guzman E, Zhou H, Audouard M, Bridges D,Tovar KR, Papuc SM, Tutulan-Cunita AC, Huang Y, Budisteanu M, Arghir A, Kosik KS. Hum Mol Genet. 2016 Apr 1;25(7):1294-306. doi: 10.1093/hmg/ddw010. PubMed PMID: 26755828. Tau-er of Power. Cerebrum. Kosik KS. 2015 May 1;2015:6. PubMed PMID: 26380035; PubMed Central PMCID: PMC4564233.