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Miles, Howard Professor 收藏
University of Central Florida     Department of Chemistry
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个人简介

Education NIH Postdoctoral Fellow, Stanford University, 1970, Synthetic Organic Chemistry Ph.D., Georgia Institute of Technology, 1970, Organic Chemistry B.S., Birmingham-Southern College, 1965, Chemistry/Mathematics Professional Experience Professor, Department of Chemistry, University of Central Florida, February 1988- Present Associate Director, Center for Diagnostics and Drug Development, University of Central Florida, 1998-1999 Co-Director, Center for Diagnostics and Drug Development, University of Central Florida, 1997–1998 2 Long term Technical Advisor in chemistry for the United States Agency for International Development (USAID) in Indonesia for the Higher Education Development Support (HEDS) Project, 1992–1994 Chair, Department of Chemistry, University of Central Florida, February 1988-1992 Senior Visiting Scientist at the University of Wisconsin and World Bank Consultant in the Department of Pharmacy at the University of Indonesia, 1986 Professor of Chemistry and Biochemistry, Mississippi State University, 1978-1988 Program Officer for the Regional Instrumentation Facilities Program, National Science Foundation, 1979 Coordinator of the Chemical Sciences Program, Mississippi State University, 1977- 1981 Associate Professor of Chemistry, Mississippi State University, 1974-1978 Assistant Professor of Chemistry, Mississippi State University, 1970-1974 National Institutes of Health Postdoctoral Fellow, Stanford University, 1969-1970 Honors and Awards UCF Teaching Incentive Program Award, 1997 UCF Teaching Incentive Program Award, 1993 UCF Premedical Club Golden Apple Teacher Award, 1997 UCF University Distinguished Researcher Award, 1995 UCF College of Arts and Sciences Distinguished Researcher Award, 1995 UCF Excellence in Undergraduate Teaching Award for the College of Arts and Sciences, 1997 Outstanding Chemist Award, Mississippi Section of the Chemical Society, 1979 Outstanding Young College Professor, Mississippi Jaycees, 1977 Alumni Award (Mississippi State University) for Excellence in Teaching and Research, 1977 Sigma Xi Award for Excellence in Research, 1974 National Institute of Health Postdoctoral Fellow, Stanford University, 1969-1970 National Institute of Health Postdoctoral Fellow, Georgia Institute of Technology, 1967-1969 National Aeronautics and Space Administration Predoctoral Fellow, Georgia Institute of Technology, 1965-1967 Theta Chi Delta (Chemistry honorary), Birmingham-Southern College, 1963-65 Theta Sigma Lambda (Mathematics honorary), Birmingham-Southern College, 1963- 65 Phi Lambda Upsilon (Chemistry honorary), Birmingham-Southern College, 1963-65

研究领域

The main goal of our research group is to discover new drug-leads that can be potentially developed into new pharmaceutical agents for the treatment of breast cancer, colon cancer, leukemia, myeloma (bone cancer), tuberculosis, and blood diseases. Currently, we are investigating plants that are indigenous to Russia and Southeast Asia in order to discover novel bioactive compounds from them. In collaboration with Professor Olga P. Kransykh (Perm State University, Russia), we are synthesizing novel heterocyclic molecules, which are then evaluated for their toxicity in mice by Professor Sergey Solodnikov, a pharmacologist at Perm State. Then, we test those compounds with low toxicity against various disease targets in collaboration with molecular biologists at UCF (Dr. Saleh Naser-TB) and the Health Research Institute of the Orlando Regional Healthcare System (Dr. David Flory). If a novel compound shows low toxicity and high activity, then we attempt to elucidate the complete mechanism of action. An effort is also underway to prepare new libraries of compounds from the natural product podocarpic acid. We have already documented the activity of some 20 novel synthetic compounds against colon cancer, breast cancer, myeloma, leukemia and tuberculosis. Eight patents have been issued to UCF based upon these findings. In addition, we have isolated many new bioactive natural products (such as, jucunsol, O-methyl embelin, and heritol) from natural products that are indigenous to the USA, Philippines, Thailand, Indonesia, Russia and Vietnam. Finally, as part of this process, we have also developed a new synthetic methodology for the selective cleavage of b-keto esters and vinylogous b-keto esters.

近期论文

“Treatment of Breast Cancer”, Miles, D. Howard; Solonikov, Sergey Yurjevich; Krasnykh, Olga Petrovna; Pimenova, Elena Valentinovna; Goun, Elena A, U. S. Patent 6,703,426 B1, 2003. “Treatment of Myeloma”, Miles, D. Howard; Solonikov, Sergey Yurjevich; Krasnykh, Olga Petrovna; Alexandrovna, Korotkova Tatiana; Goun, Elena A, U.S. Patent 6,686,496 B1, 2004. “Methyl Esters of Substituted 4-oxo-2-butenoic Acid for Treatment of Tuberculosis”, Miles, D. Howard; Krasnykh, Olga Petrovna; Saleh, Naser; Solodnikov, Sergey Yurjevich; Goun, Elena A.; Suslonov, Vladimir Michailovich, U. S. Patent 6,683,110 B1, 2004. “2-Oxo-1,4-benzoxazine Compounds for Treatment of Tuberculosis”, Miles, D. Howard; Krasnykh, Olga Petrovna; Saleh, Naser; Solodnikov, Sergey Yurjevich; Goun, Elena A.; Suslonov, Vladimir Michailovich, U.S. Patent 6,649,610 B1, 2003. “Treatment of Breast Cancer”, Miles, D. Howard; Solonikov, Sergey Yurjevich; Krasnykh, Olga Petrovna; Pimenova, Elena Valentinovna; Goun, Elena A, U.S. Patent 6,638,975 B1, 2003. “Treatment of Breast Cancer”, Miles, D. Howard; Solodnikov, Sergey Yurjevich; Krasnykh, Olga Petrovna; Pimenova, Elena Valentinovna; Goun, Elena A., U.S. Patent 6,602,907 B1, 2003. Pimenova, Elena V.; Krasnych, Olga P.,; Goun, Elena A., Miles, Howard D.; “Synthesis and Reactions of 2-Hydroxy-4-oxo-4-(2,3,5,6-tetrafluoro-4- methoxyphenyl)-but-2-enoic acid Methyl Ester”, Journal of Fluorine Chemistry, 2003, 121, 201-204. Goun, E.; Cunningham, G.; Chu, D.; Nguyen, C.; Miles, D. Howard; “Antibacterial and antifungal activity of Indonesian Ethnomedical Plants”, Fiteroterapia, 2003, 76, 592-596. Goun, E.; Cunningham, G.; Solodnikov, S.; Krasnykch, O.; Miles, D. H. “ Isolation and Evaluation of the Antithrombin and Anticancer Activity of Three Compounds from Origanum vulgare”, Fitoterapia, 73, 692-694 (2002). Goun, Elena A.; Petrichenko, V. M.; Solodnikov, S.U.; Suhinina, T.V.; Kline, 13 Martin A.; Cunningham, Glenn; Nguyen, Chi; Miles, Howard “ Anticancer and Antithrombin Acitivity of Russian Plants” Journal of Ethnopharmacology, , 81, 337- 342 (2002). Chistokhodova, Natalya; Nguyen, Chi; Calvino, Tony; Kachirskaia, Ioulia; Cunningham, Glenn; Miles, D. Howard “ Antithrombin Activity of Medicinal Plants from Central Florida” Journal of Ethnopharmacology, , 81, 277-280 (2002). Chistokhodova, N.A.; Ghiviriga, I.; Nguyen, Chi; Miles, D. H.; Ughegova, N. A.; Solodnikov. S. Yu; “Alpha-amyryl hexadecanoate from Parthenocissus quinouefolia". Khim. Farm Ghurn. , 23-25 (2002). Solodnikov, S. Yu;, Miles, D. H.; Krasnykh, O.P.;, Gun, E. A.; Naser, S. A.; Denisov, V. E.; Shilov, Yu. I. ; “ Synthesis, antithrombin and antitubercular activity of 2-hydrazine derivatives of acylpyruvates”. Khim. Farm Ghurn., 10-11 (2002). Miles, D. Howard; Payne, Matthew; “ Synthesis of 5-O-methylembelin” Tetrahedron”, 57, 5769-5772 (2001). Tip-pyang, Santi; Miles, D. Howard; “ A Search for Agrochemicals from Pluchea indica” ACGC Chemical Research Communications, , 12, 51-55 (2000). Medeiros, Jorge Manuel Rosa; Macedo, Manuelo; Contancia, Joao; Ngueyn, Chi; Cunningham, Glenn; Miles, D. Howard; “Antithrombin Activity of Medicinal Plants of the Azores” Journal of Ethnopharmacology, , 72, 157-165 (2000). “Utilization of Natural Products for Treatment of Blood Diseases,”D. Howard Miles, Chi L. Nguyen, and David H. Miles, Current Medicinal Chemistry, (5) 421-440 (1998). “The Amebicidal Activity of Plant Extracts from southeast Asia on Acenthamoeba,” Dan-My Chu, D. Howard Miles, Denise Toney, Chi Nguyen, and Francine Marciano-Cabral, Parasitology Research, 84, 746-756, (1998). “Calorimetic Cytotxicity Assay Using Lactobacillus laseu rhamnosus,” Stephen Spears, Chi Nguyen, Howard Miles, J.M. Medeiros, and Harry Price, Journal of Undergraduate Research, 3, 80-89 (1997). “Bioactive Constituents from Tropical Plants of Peru, Philippines, Vietnam, Thailand, and Indonesia,” D. Howard Miles, Sumaryati Syukur, Dan-May Chu, Chi Nguyen, Vallapa Chittawong, John Francis, Jorge Medeiros, Matt Payne, Santi Tip-Pyang and Kwanjai Tunsuwan, Proceedings of the International Seminar on Tropical Rainforests Plants and their Utilization for Development, page 36,1996.

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