Zhang, Liangfang - University of California San Diego

个人简介

Postdoc, Massachusetts Institute of Technology, Chemical Engineering PhD, University of Illinois at Urbana-Champaign, Chemical Engineering MS & BE, Tsinghua University, Chemical Engineering Prof. Liangfang Zhang received his Ph.D. in Chemical Engineering from the University of Illinois at Urbana- Champaign (UIUC) in 2006 under the supervision of Prof. Steve Granick. He was a postdoc in the laboratory of Prof. Robert Langer at MIT during 2006-2008. He holds B.E. and M.S. degrees in Chemical Engineering from Tsinghua University. He joined the Department of Nanoengineering at UC San Diego as Assistant Professor in 2008 and was promoted to Associate Professor with tenure in 2012 and to Professor in 2014.

研究领域

We work on the design, synthesis, characterization and evaluation of lipid- and polymer-based nanostructured biomaterials. One specific interest lies in developing nanomaterials for healthcare and other medical applications, for example, drug delivery to improve or enable treatments of human diseases. In addition, we also seek to understand the fundamental sciences underlying the arenas of nanomedicine. Overall, our research covers a broad scope of multidisciplinary areas including chemical & molecular engineering, materials science, chemistry, nanotechnology, biotechnology and medicine. Currently, we are interested in three specific topics: (1) developing multifunctional lipid-polymer hybrid nanoparticles as a robust drug delivery platform that combines the merits of liposomes and polymeric nanoparticles; (2) simultaneously delivering multiple drugs with different hydrophobicity to the same cancer cells for combination therapy; and (3) understanding how single nanoparticles with distinct characteristics interact with biomembranes, with special focus on understanding cellular endocytosis and endosome escape of therapeutic nanoparticles. For detailed description about these projects, you are welcome to visit our group webpage.

近期论文

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Ai, X.; Wang, S.; Duan, Y.; Zhang, Q.; Chen, M.; Gao, W.; Zhang, L.* "Emerging approaches to functionalizing cell membrane-coated nanoparticles", Biochemistry 2020, in press. Jiang, Y.; Krishnan, N.; Zhou, J.; Chekuri, S.; Wei, X.; Kroll, A.; Yu, C.; Gao, W.; Fang, R.; Zhang, L.* "Engineered cell membrane-coated nanoparticles directly present tumor antigens to promote anticancer immunity", Advanced Materials 2020, in press. Bsteban-Fernandez de Avila, B., Lopez-Ramirez, M.; Mundaca-Uribe, R.; Wei, X.; Ramirez-Herrera, D.; Karshalev, E.; Nguyen, B.; Fang, R.; Zhang, L.*, Wang, J. "Multi-compartment tubular micromotors towards enhanced localized active delivery", Advanced Materials 2020, in press. Zhang, Q.; Fang, R.; Gao, W.; Zhang, L.* "A biomimetic nanoparticle to 'lure and kill' phospholipase A2", Angewandte Chemie International Edition 2020, 59, 10461-10465. [link] Tang, S.; Zhang, F.; Gong, H.; Wei, F.; Zhuang, J.; Karshalev, E.; Bsteban-Fernandez de Avila, B., Huang, C.; Hu, Z; Zhou, Z.; Li, Z; Lu, Y.; Dong, H.; Fang, R.; Zhang, X.; Zhang, L.*, Wang, J. "Enzyme-powered Janus platelet micromotors for targeted therapeutic delivery", Science Robotics 2020, 5, eaba6137. [link] Jiang, Y.; Krishnan, N.; Heo, J.; Fang, R.; Zhang, L.* "Nanoparticle-hydrogel superstructures for biomedical applications", Journal of Controlled Release 2020, 324, 505-521. [link] Zhang, Q.; Gong, H.; Gao, W.; Zhang, L.* "Recent progress in capturing and neutralizing inflammatory cytokines", CCS Chemistry 2020, 2, 376-389. [link] Zhuang, J.; Duan, Y.; Zhang, Q.; Gao, W.; Li, S.; Fang, R.; Zhang, L.* "Multimodal enzyme delivery and therapy enabled by cell membrane-coated metal-organic framework nanoparticles", Nano Letters 2020, 20, 4051-4058. [link] Zhou, J.; Kroll, A.; Holay, M.; Fang, R.; Zhang, L.* "Biomimetic nanotechnology towards personalized vaccines", Advanced Materials 2020, 32, 1901255. [link] Zhuang, J.; Gong, H.; Zhou, J.; Zhang, Q.; Gao W.; Fang, R.; Zhang, L.* "Targeted gene silencing in vivo by platelet membrane-coated metal-organic framework nanoparticles", Science Advances 2020, 6, eaaz6108. [link] Park, J. H.; Dehaini, D.; Zhou, J.; Holay, M.; Fang, R.; Zhang, L.* "Biomimetic nanoparticle technology for cardiovascular disease detection and treatment", Nanoscale Horizons 2020, 5, 25-42. [link] Zhang, Y.; Miyamoto, Y.; Ihara, S.; Yang, J.; Zuill, D.; Angsantikul, P.; Zhang, Q.; Gao, W.; Zhang, L.*, Eckmann, L. "Composite thermoresponsive hydrogel with auranofin-loaded nanoparticles for topical treatment of vaginal trichomonad infection", Advanced Therapeutics 2019, 2, 1900157. [link] Wierzbicki, I.; Campeau, A.; Dehaini, D.; Holay, M.; Wei, X.; Greene, T.; Ying, M.; Sands, J.; Lamsa, A.; Zuniga, E.; Pogliano, K.; Fang, R.; LaRock, C.; Zhang, L.; Gonzalez, D. "Group A Streptococcal S protein utilizes red blood cells as immune camouflage and is a critical determinant for immune evasion", Cell Reports 2019, 29, 2979-2989. [link] Karshalev, E.; Zhang, Y.; Bsteban-Fernandez de Avila, B.; Beltran-Gastelum, M.; Chen, Y.; Mundaca-Uribe, R.; Zhang, F.; Nguyen, B.; Tong, Y.; Fang, R.; Zhang, L.*, Wang, J. "Micromotors for active delivery of minerals toward the treatment of iron deficiency anemia", Nano Letters 2019, 19, 7816-7826. [link] Koo, J.; Escajadillo, T.; Zhang, L.; Nizet, V.; Lawrence, S. M. "Erythrocyte-coated nanoparticles block cytotoxic effects of group B streptococcus beta-hemolysin/cytolysin", Frontiers in Pediatrics 2019, 7, 410. [link] Zhang, F.; Zhuang, J.; Bsteban-Fernandez de Avila, B.; Tang, S.; Zhang, Q.; Fang, R.; Zhang, L.*; Wang, J. "A nanomotor-based active delivery system for intracellular oxygen transport", ACS Nano 2019, 13, 11996-12005. [link] Zhuang, J.; Holay, M.; Park, J. H.; Fang, R.; Zhang, J.; Zhang, L.* "Nanoparticle delivery of immunostimulatory agents for cancer immunotherapy", Theranostics 2019, 9, 7826-7848. [link] Fang, R.; Zhang, L.* "Biomimetic nanosponges as a broad-spectrum countermeasure to biological threats", HDIAC Journal, 2019, 6(3), 14-19. [link] [journal cover] Zhang, Y.; Chen, Y.; Lo, C.; Zhuang, J.; Angsantikul, P.; Zhang, Q.; Wei, X.; Zhou, Z.; Obonyo, M.; Fang, R.; Gao, W.; Zhang, L.* "Inhibition of pathogen adhesion by bacterial outer membrane-coated nanoparticles", Angewandte Chemie International Edition 2019, 58, 11404-11408. [link] Kumar, S.; Han, J.; Michael, I.; Ki, D.; Sunkara, V.; Park, J.; Gautam, S.; Ha, H. K.; Zhang, L.; Cho, Y. "Human platelet membrane functionalized microchips with plasmonic codes for cancer detection", Advanced Functional Materials 2019, 29, 1902669. [link] [journal cover]