徐明华 - 南方科技大学

个人简介

1999年7月博士毕业于中国科学院上海有机化学研究所，先后在美国弗吉尼亚大学和乔治敦大学医学研究中心从事博士后工作研究，2003年8月加入中国科学院上海有机化学研究所，2005年入选中国科学院，7月起任中国科学院上海药物研究所研究员、课题组长、博士生导师，新药研究国家重点实验室研究员。2018年受邀加入南方科技大学，现任化学系和深圳格拉布斯研究院双聘教授。

研究领域

主要从事有机不对称合成及手性药物方面的研究研究方向包括新型手性配体/催化剂的设计及不对称反应研究生物活性分子的高效合成和小分子药物发现基于疾病诊断的小分子荧光探针研究

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Rhodium(I) Carbene-Promoted Enantioselective C-H Functionalization of Simple Unprotected Indoles, Pyrroles and Heteroanalogues: New Mechanistic Insights Tian-Yi Wang, Xiao-Xuan Chen, Dong-Xing Zhu, Lung Wa Chung, and Ming-Hua Xu* Angew. Chem. Int. Ed. 2022, e202207008 Rhodium(i)-catalyzed C-S bond formation via enantioselective carbenoid S-H insertion: catalytic asymmetric synthesis of α-thioesters Yu-Tuo Sun, Xiaofeng Rao, Weici Xu and Ming-Hua Xu* Org. Chem. Front. 2022, DOI：10.1039/D2QO00164K Applications of Asymmetric Petasis Reaction in the Synthesis of Chiral Amines Yi Li,Ming-Hua Xu* Acta Chimica Sinica 2021, 79, 1345-1359. Stereodivergent Synthesis of Enantioenriched 2,3-Disubstituted Dihydrobenzofurans via a One-Pot C–H Functionalization/Oxa-Michael Addition Cascade Dong-Xing Zhu, Jian-Guo Liu, and Ming-Hua Xu* J. Am. Chem. Soc. 2021, 143, 8583–8589 Transition Metal-Catalyzed Asymmetric Carbene Insertion for Synthesis of Chiral Amines Bo Liu, and Ming-Hua Xu* Chinese Science Bulletin, 2021, 66, 3251-3260. (in Chinese) (Invited contribution, Special issue) Facile Synthesis of Coumaronochromones through Palladium-Catalyzed Intramolecular Cross Dehydrogenative Coupling Chang-Xue Gu, Jian-Guo Liu, Wen-Wen Chen,* and Ming-Hua Xu* Tetrahedron 2021, 85, 132048-132054.(Invited contribution, Special issue in honor of Professor Guo-Qiang Lin) Rhodium(I)-Catalyzed Enantioselective C(sp3)-H Functionalization via Carbene-Induced Asymmetric Intermolecular C-H Insertion BoLiu, and Ming-Hua Xu* Chin. J. Chem. 2021, 39, 1911-1915 (Invited contribution, Special issue: Dedicated to Department of Chemistry, SUSTech, on the Occasion of Her 10th Anniversary) Regiospecific and Enantioselective Arylvinylcarbene Insertion of a C-H bond of Aniline Derivatives Enabled by a Rh(I)-Diene Catalyst Dong-Xing Zhu, Hui Xia, Jian-Guo Liu, Lung Wa Chung,* and Ming-Hua Xu* J. Am. Chem. Soc. 2021, 143. 2608-2619 Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)–Diene: Access to Nonproteinogenic β2/γ2/δ2-Amino Acid Derivatives Jian-Ping Chen, Yi Li, Chao Liu, Tianyi Wang, Lung Wa Chung, and Ming-Hua Xu* Org. Lett. 2021, 23, 571–577 (Highlighted by Synfacts, 2021, 17(4), 0462) Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3β Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity Jian-Guo Liu, Danfeng Zhao, Qi Gong, Fengxia Bao, Wen-Wen Chen*, Haiyan Zhang*, and Ming-Hua Xu* ACS Chem. Neurosci. 2020,11(20), 3398–3408 Chiral diene-promoted room temperature conjugate arylation: highly enantioselective synthesis of substituted chiral phenylalanine derivatives and α,α-di(arylmethyl)acetates Jian-Ping Chen, and Ming-Hua Xu* Org. Biomol. Chem. 2020, 18, 4569-4574 Pd(II)-Catalyzed Asymmetric Annulation toward the Synthesis of 2,3-Disubstituted Chiral Indenols Chang-Xue Gu, Wen-Wen Chen,* and Ming-Hua Xu* J. Org. Chem. 2020, 85, 3887-3893 Palladium-Catalyzed Highly Enantioselective Arylation of Cyclic N-sulfonyl α-Ketimino Esters towards the Synthesis of α-Quaternary Chiral Amino Acid Derivatives Chun-Yan Wu, and Ming-Hua Xu* ChemCatChem 2020, 12, 1129-1133 (Very Important Paper, Invited contribution, topic on Sustainable and Affordable Chemistry to Meet Future Challenges in the Pharmaceutical Industry) Transition Metal-Catalyzed Asymmetric Addition of Organoboron Reagents to Aldehydes and Ketones Chin. J. Org. Chem. 2020, 40, 255-275. Dong-Xing Zhu, and Ming-Hua Xu* The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals Yu-Tuo Sun, Dong-Xing Zhu, Xiaofeng Rao, and Ming-Hua Xu* Org. Chem. Front. 2020, 7, 340-344. Rhodium-Catalyzed Enantioselective Addition of Arylboroxines to Isatin-Derived N-Boc Ketimines Using Chiral Phosphite–Olefin Ligands: Asymmetric Synthesis of 3-Aryl-3-amino-2-oxindoles Yue-Na Yu, Wei-Yi Qi, Chun-Yan Wu and Ming-Hua Xu* Org. Lett. 2019, 21(18), 7493-7497. Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Glyoxylates:Access to Optically Active Substituted Mandelic Acid Esters Diao Chen, Jian-Guo Liu, Xu Zhang, and Ming-Hua Xu* Synlett 2019, 30, 1693-1697 (Invited contribution, Synlett Cluster issue on Organosulfur and Organoselenium Compounds in Catalysis) Construction of Chiral 1,3-Diamines through Rhodium-Catalyzed Asymmetric Arylation of Cyclic N-Sulfonyl Imines Chun-Yan Wu and Ming-Hua Xu* Org. Lett. 2019, 21(13), 5035-5039. Synthesis of indolo[2,3-c]coumarins and indolo[2,3-c]quinolinones via microwave-assisted base-free intramolecular cross dehydrogenative coupling Chang-Xue Gu, Wen-Wen Chen, Bin Xu,and Ming-Hua Xu* Tetrahedron 2019, 75, 1605-1611 (Invited contribution, Special issue in memory of Professor Wei-Shan Zhou) Highly Enantioselective Synthesis of α-Tertiary Chiral Amino Acid Derivatives through Rhodium-Catalyzed Asymmetric Arylation of Cyclic N-Sulfonyl α-Ketimino Esters Zheng Wang, and Ming-Hua Xu* Org. Biomol. Chem. 2018, 16, 4633-4640 (Cover Article, Highlighted by Synfacts, 2018, 14(9), 0943)