个人简介

Education: B.Sc., McGill University (1976); Ph.D., MIT - NSERC Postgraduate Scholar (A. Davison, FRS, 1981); NSERC Postdoctoral Fellow, University of California, Berkeley (K. N. Raymond, 1981-83); Postdoc, McMaster University (C. J. L. Lock, 1983-1984). Director, Medicinal Inorganic Chemistry Group. Awards: Fellow, Chemical Institute of Canada (1992). UBC Killam Faculty Research Fellowship (1992‑1993). Society of Pure and Applied Coordination Chemistry (SPACC) of Japan Award (1996). UBC Faculty of Science Killam Teaching Prize (1998). Alexander von Humboldt Foundation Research Award (1999-2000, 2013). UBC Faculty of Science Achievement Award for Service (2005). UBC Killam Faculty Research Prize (2006). JSPS (Japan Society for the Promotion of Science) Invitation Fellow (2007). Rio Tinto Alcan Award, Canadian Society for Chemistry (2009). Bioinorganic Chemistry Award, Royal Society of Chemistry (2009). Fellow of the Royal Society of Canada (2010). Davison Lecturer, MIT (2011). Canada Council Killam Research Fellowship (2011-13). University of Canterbury (NZ) Visiting Erskine Fellow (2013). UBC Jacob Biely Research Prize (2013). G. Ronald Brown Lecturer, McGill University (2014). Honorary Positions: International Symposium on Applied Bioinorganic Chemistry (ISABC) International Advisory Committee (2001- ). International Conference on Biological Inorganic Chemistry (ICBIC) International Organizing Committee (2007- ). Executive Secretary, International Conferences on Coordination Chemistry (2012- ). Humboldt Ambassador Scientist, Alexander von Humboldt-Stiftung, Germany (2015-2018).

研究领域

Biological & Medicinal Chemistry; Chemical Synthesis; Inorganic Chemistry; Nuclear and Radiochemistry

TEACHING PHILOSOPHY My basic teaching philosophy is to be enthusiastic about my subject, honest about potential confusions, and unambiguous in my explanations. I involve students in every lecture through a variety of mechanisms (call-and-response, intimate tutorials in which the students tell each other the answers using the chalkboard and I act as a facilitator, spot-the-trend checks, student papers/seminars, etc.). I try to make students feel that the lecture could not take place without them. I extensively use clear handouts so that the principles, not the details, are emphasized as being of importance. I de-emphasize memory work, and I stress the importance of integration of knowledge in the problem sets and exams (I tell the students this). Regurgitation is not part of my teaching philosophy. RESEARCH PROGRAMME Research projects in our labs study the roles of metal ions in the etiology, diagnosis, and therapy of disease. These projects encompass a variety of metal ions as well as numerous ligand systems and a wide panoply of techniques and collaborations. Synthesis of organic ligands and inorganic complexes as well as physical (potentiometric and spectrophotometric titrations, various spectroscopies, electrochemistry etc.) and biological studies (in cells, at UBC Bioservices and/or in collaboration) are undertaken in the research programme.

近期论文

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"Cawthray, J. F. ; Creagh, A. L. ; Haynes, C. A. ; Orvig, C. Ion Exchange In Hydroxyapatite With Lanthanides}. Inorg Chem 2015, 54, 1440–1445.BibTex Ramogida, C. F. ; Cawthray, J. F. ; Boros, E. ; Ferreira, C. L. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. H2Chxdedpa And H4Chxoctapa-Chiral Acyclic Chelating Ligands For (67/68)Ga And (111)In Radiopharmaceuticals}. Inorg Chem 2015, 54, 2017–2031.BibTex Rodriguez-Rodriguez, C. ; Telpoukhovskaia, M. A. ; Ali-Torres, J. ; Rodriguez-Santiago, L. ; Manso, Y. ; Bailey, G. A. ; Hidalgo, J. ; Sodupe, M. ; Orvig, C. Thioflavin-Based Molecular Probes For Application In Alzheimer's Disease: From In Silico To In Vitro Models. Metallomics 2015, 7, 83-92.BibTex Mjos, K. Dralle; Cawthray, J. F. ; Jamieson, G. ; Fox, J. A. ; Orvig, C. Iron(Iii)-Binding Of The Anticancer Agents Doxorubicin And Vosaroxin. Dalton Trans. 2015, 44, 2348-2358.BibTex Telpoukhovskaia, M. ; Rodríguez-Rodríguez, C. ; Cawthray, J. F. ; Scott, L. Emily; Page, B. D. G. ; Ali-Torres, J. ; Sodupe, M. ; Bailey, G. A. ; Patrick, B. O. ; Orvig, C. 3-Hydroxy-4-Pyridinone Derivatives As Metal Ion And Amyloid Binding Agents. Metallomics 2014, 6, 249-262.BibTex Price, E. W. ; Orvig, C. Matching Chelators To Radiometals For Radiopharmaceuticals. Chem. Soc. Rev. 2014, 43, 260-290.BibTex Price, E. W. ; Zeglis, B. M. ; Lewis, J. S. ; Adam, M. J. ; Orvig, C. H(6)Phospa-Trastuzumab: Bifunctional Methylenephosphonate-Based Chelator With Zr-89, In-111 And Lu-177. Dalton Trans. 2014, 43, 119-131.BibTex Mawani, Y. ; Orvig, C. Improved Separation Of The Curcuminoids, Syntheses Of Their Rare Earth Complexes, And Studies Of Potential Antiosteoporotic Activity. J. Inorg. Biochem. 2014, 132, 52-58.BibTex Telpoukhovskaia, M. A. ; Rodríguez-Rodríguez, C. ; Scott, L. E. ; Page, B. D. G. ; Patrick, B. O. ; Orvig, C. Synthesis, Characterization, And Cytotoxicity Studies Of Cu(Ii), Zn(Ii), And Fe (Iii) Complexes Of N-Derivatized 3-Hydroxy-4-Pyridiones. J. Inorg. Biochem. 2014, 132, 59-66.BibTex Mjos, K. Dralle; Orvig, C. Metallodrugs In Medicinal Inorganic Chemistry. Chem. Rev. 2014, 114, 4540-4563.BibTex Price, E. W. ; Cawthray, J. F. ; Adam, M. J. ; Orvig, C. Modular Syntheses Of H(4)Octapa And H(2)Dedpa, And Yttrium Coordination Chemistry Relevant To Y-86/y-90 Radiopharmaceuticals. Dalton Trans. 2014, 43, 7176-7190.BibTex Price, E. W. ; Ferreira, C. L. ; Adam, M. J. ; Orvig, C. High-Denticity Ligands Based On Picolinic Acid For 111In Radiochemistry. Can. J. Chem. 2014, 92, 695-705.BibTex Price, E. W. ; Zeglis, B. M. ; Cawthray, J. F. ; Lewis, J. S. ; Adam, M. J. ; Orvig, C. What A Difference A Carbon Makes: H4Octapa Vs. H4C3Octapa, Ligands For In-111 And Lu-177 Radiochemistry. Inorg. Chem. 2014, 53, 10412-10431.BibTex Spreckelmeyer, S. ; Orvig, C. ; Casini, A. Cellular Transport Mechanisms Of Cytotoxic Metallodrugs: An Overview Beyond Cisplatin. Molecules 2014, 19, 15584-15610.BibTex Telpoukhovskaia, M. A. ; Patrick, B. O. ; Rodríguez-Rodríguez, C. ; Orvig, C. Exploring The Multifunctionality Of Thioflavin- And Deferiprone-Based Molecules As Acetylcholinesterase Inhibitors For Potential Application In Alzheimer’S Disease. Molecular BioSystems 2013, 9, 792-805.BibTex Mawani, Y. ; Cawthray, J. F. ; Chang, S. ; Sachs-Barrable, K. ; Weekes, D. M. ; Wasan, K. M. ; Orvig, C. In Vitro Studies Of Lanthanide Complexes For The Treatment Of Osteoporosis. Dalton Trans. 2013, 42, 5999-6011.BibTex Ramogida, C. F. ; Orvig, C. Tumour Targeting With Radiometals For Diagnosis And Therapy. Chem. Commun. 2013, 49, 4720-4739.BibTex Telpoukhovskaia, M. A. ; Orvig, C. Werner Coordination Chemistry And Neurodegeneration. Chem. Soc. Rev. 2013, 42, 1836-1846.BibTex Dikanov, S. A. ; Liboiron, B. D. ; Orvig, C. Vo2+-Hydroxyapatite Complexes As Models For Vanadyl Coordination To Phosphate In Bone. Mol. Phys. 2013, 111, 2967-2979.BibTex Price, E. W. ; Zeglis, B. M. ; Cawthray, J. F. ; Ramogida, C. F. ; Ramos, N. ; Lewis, J. S. ; Adam, M. J. ; Orvig, C. H 4 Octapa-Trastuzumab: Versatile Acyclic Chelate System For 111 In And 177 Lu Imaging And Therapy. J. Am. Chem. Soc. 2013, 135, 12707 - 12721.BibTex