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个人简介

Prof. Guo received his Ph.D. in Chemical and Biomolecular Engineering at The University of Melbourne, Australia. He initialed the pioneering research on polyphenol-based engineering of particle and thin-film systems, including metal-phenolic network (MPN) and polyphenol-based modular assembly method. Advisor: Prof. Frank Caruso (Fellows of the Royal Society, Fellow of Australian Academy of Science, Fellow of Australian Academy of Technology and Engineering, Deputy Director of the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, CSIRO Eureka Prize for Leadership). Prof. Guo conducted research and lecturing as Wyss Fellow in the Wyss Institute for Biologically Inspired Engineering at Harvard University, United States. High-impact works have been focused on phenolic-mediated nanoengineering of microbial and mammalian cells. Advisors: Prof. Samir Mitragotri (Member of the National Academy of Engineering, National Academy of Medicine, and National Academy of Inventors, Hiller Professor of Bioengineering and Hansjorg Wyss Professor of Biologically Inspired Engineering Core Faculty Member, Wyss Institute for Biologically Inspired Engineering). Prof. Neel Joshi (Associate Professor of Chemical and Biological Engineering, Hansjorg Wyss Professor of Biologically Inspired Engineering Core Faculty Member)

研究领域

Our mission: use bio-building blocks to create materials Natural polyphenols, these plant-derived natural products, were traditionally referred to as vegetable tannins, due to their original use in the industrial process of tanning to convert animal hide into leather. The possibility to exploring the unique physicochemical and biological properties of polyphenols can serve as an important source of inspiration in the search for new and improved materials. A library of functional metal-phenolic network (MPN) nanostructured films and capsules were reported which is based on the coordination between a phenolic ligand and a range of metal ions. Furthermore, the polyphenol-based particle functionalization was discovered by Prof. Guo to facilitate an interfacial molecular interaction-induced self-assembly process. This allowed for the generation of a highly versatile and effective methodology to prepare a large variety of superstructures assembled from a wide range of building blocks. This method displayed significant versatilities of sizes, shapes, microstructures, and compositions as building blocks. The generic nature of this method led to a large family of modularly assembled superstructures including core-satellite, hollow, hierarchically organized supraparticles, and inorganic-biological hybrids. In functional aspects, the polyphenol-based materials were tailored for biosynthesis, seawater uranium extraction, advanced drug delivery, positron emission tomography (PET), magnetic resonance imaging (MRI), catalysis, electromagnetic (EM) applications, etc.

近期论文

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Flowthrough capture of microplastics through polyphenol-mediated interfacial interactions on wood sawdust.Yu Wang, Mengyue Wang, Qin Wang, Taoyang Wang, Zhengming Zhou, Marina Mehling, Tianyu Guo, Hang Zou, Xiao Xiao, Yunxiang He, Xiaoling Wang*, Orlando J. Rojas*, Junling Guo*Advanced Materials, (2023) Customizable Supraparticles Constructed from Catechol-Terminated Molecular Building Blocks with Controllable Intermolecular Interactions.Yajing Zhang, Jin Wang, Yunxiang He, Jiezhou Pan, Xin Jin, Jiaojiao Shang, Guidong Gong*, Joseph J. Richardson, Ian Manners, Junling Guo*Angewandte Chemie International Edition, (2023) Microporous membranes for ultrafast and energy-efficient removal of antibiotics through polyphenol-mediated nanointerfaces.Yu Wang, Yunxiang He, Qin Wang, Xiaoling Wang*, Blaise L. Tardy, Joseph J. Richardson, Orlando J. Rojas, Junling Guo*Matter, (2023) Emerging Self-assembled Nanoparticles Constructed from Natural Polyphenols for Intestinal Diseases.Qinling Liu, Yunxiang He, Yan Fang, Yue Wu, Guidong Gong, Xiao Du*, Junling Guo* Advanced NanoBiomed Research, (2023) - Invited Review Systemic tumor suppression via macrophage-driven automated homing of metal-phenolic-gated nanosponges for metastatic melanoma.Xue Liao, Guidong Gong, Mengyuan Dai, Zhenyu Xiang, Jiezhou Pan, Xianglian He, Jiaojiao Shang*, Anna Maria Blocki, Zongmin Zhao, C. Wyatt Shields IV, Junling Guo* Advanced Science, (2023) Mechanically robust and transparent organohydrogel‐based e‐skin nanoengineered from natural skin.Zhongxue Bai, Xuechuan Wang*, Manhui Zheng, Ouyang Yue, Mengchen Huang, Xiaoliang Zou, Boqiang Cui, Long Xie, Shuyin Dong, Jiaojiao Shang, Guidong Gong, Anna M. Blocki, Junling Guo*, Xinhua Liu* Advanced Functional Materials, (2023) Synergistic Adsorption and In Situ Catalytic Conversion of SO2 by Transformed Bimetal-Phenolic Functionalized Biomass.Gao Xiao, Qiuping Xie, Yunxiang He, Xin Huang, Joseph J. Richardson, Manna Dai, Jian Hua, Xin Li, Junling Guo*, Xuepin Liao*, and Bi Shi Environmental Science & Technology, (2023) Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels.Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang*, Orlando J. Rojas, Yong Zeng*, Junling Guo*Journal of Controlled Release, (2023) Liquid metal compartmented by polyphenol-mediated nanointerfaces enables high-performance thermal management on electronic devices.Chaojun Zhang, Yang Tang, Tianyu Guo, Yizhou Sang, Ding Li, Xiaoling Wang,* Orlando J. Rojas, Junling Guo*InfoMat, (2023) Flowthrough capture of microplastics through polyphenol-mediated interfacial interactions on wood sawdust.Yu Wang, Mengyue Wang, Qin Wang, Taoyang Wang, Zhengming Zhou, Marina Mehling, Tianyu Guo, Hang Zou, Xiao Xiao, Yunxiang He, Xiaoling Wang*, Orlando J. Rojas*, Junling Guo*Advanced Materials, (2023) Customizable Supraparticles Constructed from Catechol-Terminated Molecular Building Blocks with Controllable Intermolecular Interactions.Yajing Zhang, Jin Wang, Yunxiang He, Jiezhou Pan, Xin Jin, Jiaojiao Shang, Guidong Gong*, Joseph J. Richardson, Ian Manners, Junling Guo*Angewandte Chemie International Edition, (2023) Microporous membranes for ultrafast and energy-efficient removal of antibiotics through polyphenol-mediated nanointerfaces.Yu Wang, Yunxiang He, Qin Wang, Xiaoling Wang*, Blaise L. Tardy, Joseph J. Richardson , Orlando J. Rojas , Junling Guo* Matter, (2023) Systemic tumor suppression via macrophage-driven automated homing of metal-phenolic-gated nanosponges for metastatic melanoma.Xue Liao, Guidong Gong, Mengyuan Dai, Zhenyu Xiang, Jiezhou Pan, Xianglian He, Jiaojiao Shang*, Anna Maria Blocki, Zongmin Zhao, C. Wyatt Shields IV, Junling Guo* Advanced Science, (2023) A biologically stable, self-catalytic DNAzyme machine encapsulated by metal-phenolic nanoshells for multiple microRNA imaging.Xin Jin, Qin Wang, Jiezhou Pan, Jin Wang, Yunxiang He, Jiaojiao Shang, Mei Chen, Xianglian He, Yaoyao Zhang, Bo Wang, Yajie Wang, Guidong Gong*, Junling Guo* Chinese Chemical Letters, (2023) Protocol for fabrication of the absorption-based regenerable microporous membrane for ultrafast and energy-efficient removal of antibiotics.Yu Wang, Taoyang Wang, Mengyue Wang, Xiaoling Wang*, Junling Guo* STAR Protocols, (2023) Mechanically robust and transparent organohydrogel‐based e‐skin nanoengineered from natural skin.Zhongxue Bai, Xuechuan Wang*, Manhui Zheng, Ouyang Yue, Mengchen Huang, Xiaoliang Zou, Boqiang Cui, Long Xie, Shuyin Dong, Jiaojiao Shang, Guidong Gong, Anna M. Blocki, Junling Guo*, Xinhua Liu* Advanced Functional Materials, (2023) Advancing bio-based materials for sustainable solutions to food packaging.Blaise L. Tardy*, Joseph J. Richardson, Luiz G. Greca, Junling Guo, Julien Bras, Orlando J. Rojas Nature Sustainability, (2022) Engineering of bioactive nanocomplexes on dental floss for targeted gingival therapy.Mayuka Nakajima, Nao Nakajima, Junling Guo*, Samir Mitragotri*Bioengineering & Translational Medicine, (2022) ​ Ultrasound‐mediated delivery of flexibility‐tunable polymer drug conjugates for treating glioblastoma.Tao Sun, Vinu Krishnan, Daniel C. Pan, Sergey K. Filippov, Sagi Ravid, Apoorva Sarode, Jayoung Kim, Yongzhi Zhang, Chanikarn Power, Sezin Aday, Junling Guo, Jeffrey M. Karp, Nathan J. McDannold, Samir S. Mitragotri* Bioengineering & Translational Medicine, (2022) Benchmarking supramolecular adhesive behaviour of nanocelluloses, cellulose derivatives and proteins.Otso I. V. Luotonen, Luiz G. Greca, Gustav Nyström, Junling Guo, Joseph J. Richardson, Orlando J Rojas*, Blaise L. Tardy* Carbohydrate Polymers, (2022) Red blood cell anchoring enables targeted transduction and re‐administration of AAV‐mediated gene therapy.Zongmin Zhao, Jayoung Kim, Vinny Chandran Suja, Neha Kapate, Yongsheng Gao, Junling Guo, Vladimir R. Muzykantov, Samir Mitragotri* Advanced Science, (2022) Customizable metal-phenolic supraparticles based on rationally designed building blocks.Yajing Zhang, Jin Wang, Yunxiang He, Jiezhou Pan, Xue Liao, Xin Jin, Jiaojiao Shang, Guidong Gong*, Joseph J Richardson, Junling Guo* ChemRxiv, (2022) Self‐assembled integrative nutrient carrier platform containing green tea catechin for short bowel syndrome treatment.Zhengming Zhou, Ke Li, Lei Shi, Yunfeng Wang, Yunxiang He, Wen Hu*, Junling Guo* Advanced Healthcare Materials, (2022)- Cover Article Multifunctional dual cross‐linked bioadhesive patch with low immunogenic response and wet tissues adhesion.Yang Tang, Guidong Gong, Xianglian He, Mengyuan Dai, Mei Chen, Bo Wang, Yajie Wang, Xiaoling Wang*, Junling Guo* Advanced Healthcare Materials, (2022)- Cover Article Near infrared light-induced dynamic modulation of enzymatic activity through polyphenol-functionalized liquid metal nanodroplets.Chaojun Zhang, Yang Tang, Qin Wang, Yunxiang He, Xiaoling Wang*, Sebastian Beyer, Junling Guo* Chinese Chemical Letters, (2022) Microporous membranes for ultrafast and energy-efficient removal of antibiotics through polyphenol-mediated nanointerfaces.Yu Wang, Yunxiang He, Qin Wang, Xiaoling Wang*, Blaise L. Tardy, Joseph J. Richardson, Orlando J. Rojas, Junling Guo* Matter, (2022) A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea.Jiezhou Pan, Guidong Gong, Qin Wang, Jiaojiao Shang, Yunxiang He, Chelsea Catania, Dan Birnbaum, Yifei Li, Zhijun Jia, Yaoyao Zhang*, Neel S. Joshi*, Junling Guo* Nature Communications, (2022) Intratumoral synthesis of transformable metal-phenolic nanoaggregates with enhanced tumor penetration and retention for photothermal immunotherapy.Xianglian He, Hongfu Zhu, Jiaojiao Shang, Meifeng Li, Yaoyao Zhang, Shicheng Zhou, Guidong Gong*, Yunxiang He*, Anna Blocki, Junling Guo* Theranostics, (2022) Driving forces and molecular interactions in the self-assembly of block copolymers to form fiber-like micelles.Yunxiang He, Yang Tang, Yifan Zhang, Liam MacFarlane, Jiaojiao Shang, Heping Shi, Qiuping Xie, Hui Zhao*, Ian Manners, Junling Guo* Applied Physics Reviews, (2022) Biomass-based encapsulating material for probiotic protection and methods of use thereof.Junling Guo, Yaoyao Zhang, Jiezhou Pan, Guidong Gong US Patent App., (2022) The role of extracellular matrix on unfavorable maternal–fetal interface: focusing on the function of collagen in human fertility.Rang Liu, Mengyuan Dai, Guidong Gong, Mei Chen, Canhui Cao, Tianren Wang, Zhenhui Hou, Yu Shi, Junling Guo*, Yaoyao Zhang*, Xi Xia* Journal of Leather Science and Engineering, (2022) Collagen-based materials in reproductive medicine and engineered reproductive tissues.Hanxiao Chen, Luqi Xue, Guidong Gong, Jiezhou Pan, Xiaoling Wang, Yaoyao Zhang*, Junling Guo*, Lang Qin* Journal of Leather Science and Engineering, (2022) Nanostructured particles assembled from natural building blocks for advanced therapies.Yi Ju, Haotian Liao, Joseph J Richardson, Junling Guo*, Frank Caruso* Chemical Society Review, (2022)- Invited Review Alloyed nanostructures integrated metal-phenolic nanoplatform for synergistic wound disinfection and revascularization.Yi Xie, Shengqiu Chen, Xu Peng, Xiaoling Wang, Zhiwei Wei, Joseph J. Richardson, Kang Liang, Hirotaka Ejima, Junling Guo*, Changsheng Zhao* Bioactive Materials, (2022) Engineering microparticles based on solidified stem cell secretome with an augmented pro-angiogenic factor portfolio for therapeutic angiogenesis.Thomas Später, Marisa Assunção, Kwok Keung Lit, Guidong Gong, Xiaoling Wang, Yi-Yun Chen, Ying Rao, Yucong Li, Chi Him Kendrick Yiu, Matthias W Laschke, Michael D Menger, Dan Wang, Rocky S Tuan, Kay-Hooi Khoo, Michael Raghunath, Junling Guo*, Anna Blocki* Bioactive Materials, (2022) Imparting reusable and SARS-CoV-2 inhibition properties to standard masks through metal-organic nanocoatings.Xiaoling Wang#, Ting Hu#, Bing Hu, Yan Liu, Yu Wang, Yunxiang He, Yan Li, Kun Cai*, Xingcai Zhang*, Junling Guo* Journal of Hazardous Materials, (2022) Natural polyphenol-based nanoengineering of collagen-constructed hemoperfusion adsorbent for the excretion of heavy metals.Meifeng Li, Xiaoling Wang, Guidong Gong, Yi Tang, Yaoyao Zhang, Junling Guo*, Xuepin Liao*, Bi Shi Journal of Hazardous Materials, (2022) Self-assembly of nanomicelles with rationally designed multifunctional building blocks for synergistic chemo-photodynamic therapy.Guidong Gong, Jiezhou Pan, Yunxiang He, Jiaojiao Shang, Xiaoling Wang, Yaoyao Zhang, Guolin Zhang, Fei Wang*, Gang Zhao*, Junling Guo*Theranostics, (2022) Fabrication of super-high transparent cellulose films with multifunctional performances via postmodification strategy.Ying Qi, Shaojian Lin, Jianwu Lan, Yifei Zhan, Junling Guo, Jiaojiao Shang* Carbohydrate Polymers, (2021) Modular biohybrid systems and methods of use thereof.Junling Guo, Miguel Suastegui, Neel S. Joshi US Patent App, (2021) Superstructured mesocrystals through multiple inherent molecular interactions for highly reversible sodium-ion batteries.Xiaoling Qiu, Xiaoling Wang, Yunxiang He, Jieying Liang, Kang Liang, Blaise L. Tardy, Joseph J. Richardson, Ming Hu, Hao Wu,* Yun Zhang*, Orlando J. Rojas, Ian Manners, Junling Guo* Science Advances, (2021) Biofilms in plant-based fermented foods: Formation mechanisms, benefits and drawbacks on quality and safety, and functionalization strategies.Chuanjie Gong, Yunxiang He, Yao Tang, Rong Hu, Yuanping Lv, Qisheng Zhang, Blaise L Tardy, Joseph J Richardson, Qiang He, Junling Guo*, Yuanlong Chi* Trends in Food Science & Technology, (2021) Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in lung metastases.Zongmin Zhao, Anvay Ukidve, Vinu Krishnan, Alexandra Fehnel, Daniel C. Pan, Yongsheng Gao, Jayoung Kim, Michael A. Evans, Abhirup Mandal, Junling Guo, Vladimir R. Muzykantov, Samir Mitragotri* Nature Biomedical Engineering, (2021) A heterostructure-in-built multichambered host architecture enabled by topochemical self-nitridation for rechargeable lithiated silicon-polysulfide full battery.Yunhong Wei, Mi Zhang, Li Yuan, Boya Wang, Hongmei Wang, Qian Wang, Yun Zhang*, Junling Guo*, Hao Wu* Advanced Functional Materials, (2021) Skin-inspired gelatin-based flexible bio-electronic hydrogel for wound healing promotion and motion sensing.Manhui Zheng, Xuechuan Wang*, Ouyang Yue, Mengdi Hou, Huijie Zhang, Sebastian Beyer, Anna Maria Blocki, Qin Wang, Guidong Gong, Xinhua Liu*, Junling Guo* Biomaterials, (2021) Engineered liver-inspired collagen matrix as a high-performance hemoperfusion adsorbent for bilirubin removal.Meifeng Li, Xiaoling Wang, Guidong Gong, Xia Li, Yi Tang, Qin Wang, Jibo Zhou, Junling Guo*, Xuepin Liao*, Bi Shi Chemical Engineering Journal, (2021) Thermoresponsive hemostatic hydrogel with a biomimetic nanostructure constructed from aggregated collagen nanofibers.Xinhua Liu*, Mengdi Hou, Xiaomin Luo, Manhui Zheng, Xuechuan Wang*, Huijie Zhang, Junling Guo* Biomacromolecules, (2021) Rapid assembly of colorless antimicrobial and anti-odor coatings from polyphenols and silver.Joseph J Richardson, Wenting Liao, Jincai Li, Bohan Cheng, Chenyu Wang, Taku Maruyama, Blaise L Tardy, Junling Guo, Lingyuan Zhao, Wanping An, Hirotaka Ejima Scientific Reports, (2021) Hyaluronic a cid–doxorubicin nanoparticles for targeted treatment of colorectal cancer.Daniel C Pan, Vinu Krishnan, Alyssa K Salinas, Jayoung Kim, Tao Sun, Sagi Ravid, Kevin Peng, Debra Wu, Md Nurunnabi, Jeffery A Nelson, Zachary Niziolek, Junling Guo, Samir Mitragotri* Bioengineering & Translational Medicine, (2021) Collagen peptide provides streptomyces coelicolor CGMCC 4.7172 with abundant precursors for enhancing undecylprodigiosin production.Xia Li, Meifeng Li, Junling Guo, Xian Liu, Xuepin Liao*, Bi Shi Journal of Leather Science and Engineering, (2021) ​ Collagen peptide provides saccharomyces cerevisiae with robust stress tolerance for enhanced bioethanol production.Xia Li, Nengkai Cen, Lu Liu, Yongle Chen, Xi Yang, Kang Yu, Junling Guo, Xuepin Liao*, Bi Shi ACS Applied Materials & Interfaces, (2020) Research on X-ray shielding performance of wearable Bi/Ce-natural leather composite materials.Qian Li, Yaping Wang, Xiao Xiao*, Rui Zhong, Jiali Liao, Junling Guo, Xuepin Liao*, Bi Shi Journal of Hazardous Materials, (2020) Engineering of living cells with polyphenol-functionalized biologically active nanocomplexes.Zongmin Zhao, Daniel C. Pan, Qin M. Qi, Jayoung Kim, Neha Kapate, Tao Sun, C. Wyatt Shields IV, Lily Li-Wen Wang, Debra Wu, Christopher J. Kwon, Wei He, Junling Guo*, Samir Mitragotri* Advanced Materials, (2020) Advanced X-ray shielding materials enabled by the coordination of well-dispersed high-Z elements in natural leather.Yaping Wang, Pingping Ding, Heng Xu, Qian Li, Junling Guo, Xuepin Liao*, Bi Shi ACS Applied Materials & Interfaces, (2020) Anisotropic adhesion: exploiting supramolecular interactions from polymeric colloids for strong anisotropic adhesion between solid surfaces.Blaise L. Tardy*, Joseph J. Richardson, Luiz G. Greca, Junling Guo, Hirotaka Ejima*, Orlando J. Rojas* Advanced Materials, (2020) Oral delivery of sorafenib through spontaneous formation of ionic liquid nanocomplexes.Yujie Shi, Zongmin Zhao, Yongsheng Gao, Daniel C. Pan, Alyssa K. Salinas, Eden E. L. Tanner, Junling Guo, Samir Mitragotri* Journal of Controlled Release, (2020) Lightweight and wearable X‐ray shielding material with biological structure for low secondary radiation and metabolic saving performance.Yaping Wang, Rui Zhong, Qian Li, Jiali Liao, Ning Liu, Neel S Joshi, Bi Shi, Xuepin Liao*, Junling Guo* Advanced Materials Technologies, (2020) Nanocarrier‐mediated cytosolic delivery of biopharmaceuticals.Wei He, Xuyang Xing, Xiaoling Wang, Debra Wu, Wei Wu, Junling Guo*, Samir Mitragotri* Advanced Functional Materials, (2020) - Invited Review Layered self-assemblies for controlled drug delivery: A translational overview.Apoorva Sarode, Akshaya Annapragada, Junling Guo, Samir Mitragotri* Biomaterials, (2020) Exploiting supramolecular interactions from polymeric colloids for strong anisotropic adhesion between solid surfaces.Blaise L. Tardy, Joseph J. Richardson, Luiz G. Greca, Junling Guo, Hirotaka Ejima*, Orlando J. Rojas* Advanced Materials, (2020) - Cover Article Hierarchical assembly of nanostructured coating for siRNA-based dual therapy of bone regeneration and revascularization.Helin Xing, Xing Wang, Gao Xiao, Zongmin Zhao, Shiquan Zou, Man Li, Joseph J Richardson, Blaise L Tardy, Liangxia Xie, Satoshi Komasa, Joji Okazaki, Qingsong Jiang*, Guodong Yang*, Junling Guo* Biomaterials, (2020)

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