个人简介

B.S. (chemistry) 1978, Spring Hill College, Mobile AL; Ph.D. 1981, University of Michigan, Ann Arbor MI (M. Koreeda); Postdoc 1982-84, Yale University, New Haven, CT (S. Danishefsky). A. P. Sloan Fellow, 1994-98; Merck & Co. Academic Development Prize, 2001-2. Canada Research Chair in Synthetic Organic Chemistry, 2004

研究领域

Chemical Synthesis; Organic Chemistry

Research in this group is directed toward the total synthesis of nitrogenous natural products that possess interesting structures and useful biological activities. In the course of these endeavors, great emphasis is placed on the development of innovative, efficient, and environmentally responsible preparative reactions. Possibilities are currently being sought in areas as diverse as main-group, transition-, and f-block organometallic chemistry; enzymatic transformations; photochemistry; heterocycles; hypervalent iodine chemistry, etc. Problems of current interest encompass the synthesis of thiopeptide antibiotics (genetic modulators and inhibitors of protein synthesis); of polyoxazole natural products, e.g. telomestatin (potent and selective inhibitor of human telomerase); of substances incorporating medium-ring nitrogen heterocycles or surrogates thereof; e.g. mitomycinoids (antitumor agents); and of spirocyclic alkaloids (immunusuppressants; cytotoxic agents; ion-channel blockers; and so on). These substances are of great interest in oncology, neurology, microbiology, immunology, and genetics. Our research is thus especially relevant to the objectives of UBC's Drug Research Institute, an exciting multidisciplinary initiative, and of the pharmaceutical industry.

近期论文

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Ciufolini, M. A. Synthetic Studies On Heterocyclic Natural Products. Can. J. Chem. 2014, 91.BibTex Kasahara, T. ; Jang, Y. J. ; Racicot, L. ; Panagopoulos, D. ; Liang, S. H. ; Ciufolini, M. A. Iodonium Metathesis Reactions. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2014, 53, 9637-9639.BibTex 2013 Chau, J. ; Xu, S. ; Ciufolini, M. A. Assembly Of A Key Dienic Intermediate For Tetrodotoxin Via A Machetti-Desarlo Reaction. JOURNAL OF ORGANIC CHEMISTRY 2013, 78, 11901-11910.BibTex Tam, Y. Yi C. ; Chen, S. ; Zaifman, J. ; Tam, Y. K. ; Lin, P. J. C. ; Ansell, S. ; Roberge, M. ; Ciufolini, M. A. ; Cullis, P. R. Small Molecule Ligands For Enhanced Intracellular Delivery Of Lipid Nanoparticle Formulations Of Sirna. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 2013, 9, 665-674.BibTex Smith, M. R. ; Kim, J. Yun; Ciufolini, M. A. Pd-Arylurea Complexes For The Heck Arylation Of Crotonic And Cinnamic Substrates. TETRAHEDRON LETTERS 2013, 54, 2042-2045.BibTex Lin, P. J. C. ; Tam, Y. Yi C. ; Hafez, I. ; Sandhu, A. ; Chen, S. ; Ciufolini, M. A. ; Nabi, I. R. ; Cullis, P. R. Influence Of Cationic Lipid Composition On Uptake And Intracellular Processing Of Lipid Nanoparticle Formulations Of Sirna. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 2013, 9, 233-246.BibTex Kasahara, T. ; Ciufolini, M. A. Further Studies Toward Himandrine Via Sequential Oxidative Amidation - Intramolecular Diels-Alder Reactions. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE 2013, 91, 82-90.BibTex Smith, M. R. ; Jang, Y. Jin; Kim, J. Yun; Ciufolini, M. A. Selective Reactivity Of Electron-Rich Aryl Iodides In The Heck Arylation Of Disubstituted Alkenes Catalyzed By Palladium-Arylurea Complexes. TETRAHEDRON 2013, 69, 10139-10151.BibTex Chau, J. ; Ciufolini, M. A. Bimolecular Oxidative Amidation Of Phenols: 1-(Acetylamino)4-Oxo-2,5-Cyclohexadiene-1-Acetic Acid, Methyl Ester. Org. Syn. 2013, 90, 190.BibTex 2012 Turner, C. Dylan; Ciufolini, M. A. Useful Building Blocks For The Stereocontrolled Assembly Of 2,3,5-Trisubstituted Pyrrolidines. HETEROCYCLES 2012, 85, 85-94.BibTex Braud, S. ; Ciufolini, M. A. ; Harosh, I. Enteropeptidase: A Gene Associated With A Starvation Human Phenotype And A Novel Target For Obesity Treatment. PLOS ONE 2012, 7, e49612.BibTex Turner, C. Dylan; Ciufolini, M. A. ``extreme'' Ugi Reactions With Some Complex Alpha-Amino Acids. ORGANIC LETTERS 2012, 14, 4970-4973.BibTex Lee, J. B. ; Zhang, K. ; Tam, Y. Yi C. ; Tam, Y. K. ; Belliveau, N. M. ; Sung, V. Y. C. ; Lin, P. J. C. ; LeBlanc, E. ; Ciufolini, M. A. ; Rennie, P. S. ; Cullis, P. R. Lipid Nanoparticle Sirna Systems For Silencing The Androgen Receptor In Human Prostate Cancer In Vivo. INTERNATIONAL JOURNAL OF CANCER 2012, 131, E781-E790.BibTex 2011 Kim, S. ; Ciufolini, M. A. Complete Facial Selectivity In The Diels-Alder Reaction Of A 5-Amino-5-Carboxycyclopentadiene Derivative. ORGANIC LETTERS 2011, 13, 3274-3277.BibTex Aulakh, V. S. ; Ciufolini, M. A. Total Synthesis And Complete Structural Assignment Of Thiocillin I. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011, 133, 5900-5904.BibTex Turner, C. D. ; Ciufolini, M. A. Ugi Reactions At The Limit: A Modular Approach To The Tetrahydroisoquinoline Natural Products. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2011, 241}, Meeting Abstract = {79-ORGN.BibTex Zhang, J. ; Coqueron, P. - Y. ; Ciufolini, M. A. Development And Applications Of An Oxazole-Forming Reaction. HETEROCYCLES 2011, 82, 949+.BibTex Zhang, J. ; Ciufolini, M. A. An Approach To The Bis-Oxazole Macrocycle Of Diazonamides. ORGANIC LETTERS 2011, 13, 390-393.BibTex Jen, T. ; Mendelsohn, B. A. ; Ciufolini, M. A. Oxidation Of Alpha-Oxo-Oximes To Nitrile Oxides With Hypervalent Iodine Reagents. JOURNAL OF ORGANIC CHEMISTRY 2011, 76, 728-731.BibTex Liang, H. ; Ciufolini, M. A. Chiral Hypervalent Iodine Reagents In Asymmetric Reactions. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2011, 50, 11849-11851.BibTex Turner, C. Dylan; Ciufolini, M. A. Oxidation Of Oximes With Hypervalent Iodine Reagents: Opportunities, Development, And Applications. ARKIVOC 2011, 410-428.BibTex Basha, G. ; Novobrantseva, T. ; Rosin, N. ; Ciufolini, M. ; Tam, Y. Y. C. ; Hafez, I. M. ; Wong, M. ; Sugo, T. ; Ruda, V. ; Klebanov, B. ; Qin, J. ; Akinc, A. ; J., H. ;M. ; Cullis, P. R. Influence Of Cationic Lipid Composition On Uptake, Intracellular Trafficking And Gene Silencing Properties Of Lipid Nanoparticle Formulations Of Sirna In Primary Antigen Presenting Cells. Molecular Theraphy 2011, 19, 2186.BibTex Turner, C. Dylan; Ciufolini, M. A. Directed Aromatic Functionalization In Natural-Product Synthesis: Fredericamycin A, Nothapodytine B, And Topopyrones B And D. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 2011, 7, 1475-1485.BibTex Chau, J. ; Ciufolini, M. A. The Chemical Synthesis Of Tetrodoxin: An Ongoing Quest. MARINE DRUGS 2011, 9, 2046-2074.BibTex