个人简介

B.Sc., Alberta (1969); M.Sc., Berkeley (1970); Ph.D., California at San Diego (D.J. Faulkner, 1975); Postdoctoral, M.I.T., (G. Büchi 1975-76); Chemical Institute of Canada - Merck Sharpe and Dohme Lecture Award (1987), Royal Society of Canada - Rutherford Medal in Chemistry (1988); UBC Killam Research Prize (1987); Fellow of the Chemical Institute of Canada (1987); UBC Killam Faculty Research Fellowship (1993); Fellow of the Royal Society of Canada (2000); Arthur E. Schwarting Award, American Society of Pharmacognosy (2003); Killam Graduate Teaching Prize, UBC (2005); R.U.Lemieux Award, CSC (2009); Jacob Biely Research Prize, UBC (2011); Paul J. Scheuer Award (2012); CIC Medal (2012)

研究领域

Biological & Medicinal Chemistry; Organic Chemistry

The research interests of Dr. Andersen's group involve the isolation and structure elucidation of novel organic metabolites produced by marine organisms. Biosynthetic studies are carried out on the novel metabolites when it is feasible. The structures of the new metabolites are elucidated primarily by spectroscopic analysis. Multipulse 1D and 2D nmr experiments play a pivotal role in the structure elucidation. As a rule, the molecules investigated have to meet one or more of the following criteria: i) they should be of theoretical interest due to the novelty of their biogenesis - for example terpenes with new carbon skeletons, ii) they should display in vitro biological activity which makes them potential leads for the development of pharmaceutical agents and/or iii) they should display biological activities that allow them to play a central role in the biology of the producing organism (i.e. chemical ecology). Some current projects are described below. Marine invertebrates and bacteria are cont inually collected from tropical and cold temperate ocean habitats and their extracts are screened for novel cytotoxic secondary metabolites that are potential leads for the development of new anticancer drugs. Marine bacteria are being examined as a source of novel antibiotics that are active against 'antibiotic resistant' human pathogens. Marine invertebrate and microbial extracts are being examined as a source of i) novel protein phosphatase and protein kinase inhibitors, ii) novel antimitotic agents, and iii) new cell cycle check point inhibitors. Dorid nudibranchs are delicate, shell-less and often highly colored molluscs that are apparently ill equipped to ward off predators. The defensive metabolites found in the skin extracts of nudibranchs are being studied. Recent efforts have been focused on using stable isotope methodology to study the de novo biosynthesis of terpenoid and polyketide metabolites by dorid nudibranchs.

近期论文

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Du, Y. - L. ; Dalisay, D. S. ; Andersen, R. J. ; Ryan, K. S. N-Carbamoylation Of 2,4-Diaminobutyrate Reroutes The Outcome In Padanamide Biosynthesis. Chemistry & Biology 2013, 20, 1002-1011.BibTex 2010 Daoust, J. ; Fontana, A. ; Merchant, C. E. ; de Voogd, N. J. ; Patrick, B. O. ; Kieffer, T. J. ; Andersen, R. J. Ansellone A, A Sesterterpenoid Isolated From The Nudibranch Cadlina Luteromarginata And The Sponge Phorbas Sp., Activates The Camp Signaling Pathway. Organic Letters 2010, 12, 3208 - 3211.BibTex Williams, D. E. ; Amlani, A. ; Dewi, A. S. ; Patrick, B. O. ; van Ofwegen, L. ; Mui, A. L. - F. ; Andersen, R. J. Australin E Isolated From The Soft Coral Cladiella Sp. Collected In Pohnpei Activates The Inositol 5-Phosphatase Ship1. Australian Journal of Chemistry 2010, 63, 895 - 900.BibTex Carr, G. ; Williams, D. E. ; Diaz-Marrero, A. R. ; Patrick, B. O. ; Bottriell, H. ; Balgi, A. D. ; Donohue, E. ; Roberge, M. ; Andersen, R. J. Bafilomycins Produced In Culture By Streptomyces Spp. Isolated From Marine Habitats Are Potent Inhibitors Of Autophagy. Journal of Natural Products 2010, 73, 422 - 427.BibTex Meimetis, L. G. ; Nodwell, M. ; Wang, C. ; Yang, L. ; Mui, A. L. ; Ong, C. ; Krystal, G. ; Andersen, R. J. Development Of Ship Activators: Potentially Selective Cancer Therapy. In; American Chemical Society, 2010; p. ORGN-936.BibTex Andersen, R. J. ; Mawji, N. R. ; Wang, J. ; Wang, G. ; Haile, S. ; Myung, J. - K. ; Watt, K. ; Tam, T. ; Yang, Y. Chi; Banuelos, C. A. ; Williams, D. E. ; McEwan, I. J. ; Wang, Y. ; Sadar, M. D. Regression Of Castrate-Recurrent Prostate Cancer By A Small-Molecule Inhibitor Of The Amino-Terminus Domain Of The Androgen Receptor. Cancer cell 2010, 17, 535 - 46.BibTex Pereira, A. R. ; Strangman, W. K. ; Marion, F. ; Feldberg, L. ; Roll, D. ; Mallon, R. ; Hollander, I. ; Andersen, R. J. Synthesis Of Phosphatidylinositol 3-Kinase (Pi3K) Inhibitory Analogues Of The Sponge Meroterpenoid Liphagal. Journal of Medicinal Chemistry 2010, 53, 8523 - 8533.BibTex Nodwell, M. ; Zimmerman, C. ; Roberge, M. ; Andersen, R. J. Synthetic Analogues Of The Microtubule-Stabilizing Sponge Alkaloid Ceratamine A Are More Active Than The Natural Product. Journal of Medicinal Chemistry 2010, 53, 7843 - 7851.BibTex 2009 Carr, G. ; Tay, W. ; Bottriell, H. ; Andersen, S. K. ; Mauk, A. G. ; Andersen, R. J. Plectosphaeroic Acids A, B, And C, Indoleamine 2,3-Dioxygenase Inhibitors Produced In Culture By A Marine Isolate Of The Fungus Plectosphaerella Cucumerina. Organic Letters 2009, 11, 2996-2999.BibTex Williams, D. E. ; Yu, K. ; Behrisch, H. W. ; Van Soest, R. ; Andersen, R. J. Rolloamides A And B, Cytotoxic Cyclic Heptapeptides Isolated From The Caribbean Marine Sponge Eurypon Laughlini. Journal of Natural Products 2009, 72, 1253-1257.BibTex Pereira, A. ; Pfeifer, T. A. ; Grigliatti, T. A. ; Andersen, R. J. Functional Cell-Based Screening And Saturation Transfer Double-Difference Nmr Have Identified Haplosamate A As A Cannabinoid Receptor Agonist. Acs Chemical Biology 2009, 4, 139-144.BibTex Nodwell, M. ; Pereira, A. ; Riffell, J. L. ; Zimmerman, C. ; Patrick, B. O. ; Roberge, M. ; Andersen, R. J. Synthetic Approaches To The Microtubule-Stabilizing Sponge Alkaloid Ceratamine A And Desbromo Analogues. Journal of Organic Chemistry 2009, 74, 995-1006.BibTex Ho, C. H. ; Magtanong, L. ; Barker, S. L. ; Gresham, D. ; Nishimura, S. ; Natarajan, P. ; Koh, J. L. Y. ; Porter, J. ; Gray, C. A. ; Andersen, R. J. ; Giaever, G. ; Nislow, C. ; Andrews, B. ; Botstein, D. ; Graham, T. R. ; Yoshida, M. ; Boone, C. A Molecular Barcoded Yeast Orf Library Enables Mode-Of-Action Analysis Of Bioactive Compounds. Nature Biotechnology 2009, 27, 369-377.BibTex Williams, D. E. ; Marques, S. O. ; Hajdu, E. ; Peixinho, S. ; Andersen, R. J. ; Berlinck, R. G. S. Pyrodysinoic Acid Derivatives From The Marine Sponge Dysidea Robusta. Journal of Natural Products 2009, 72, 1691-1694.BibTex Forestier, R. ; Merchant, C. E. ; de Voogd, N. J. ; Matainaho, T. ; Kieffer, T. J. ; Andersen, R. J. Alotaketals A And B, Sesterterpenoids From The Marine Sponge Hamigera Species That Activate The Camp Cell Signaling Pathway. Organic Letters 2009, 11, 5166-5169.BibTex Williams, D. E. ; Hollander, I. ; Feldberg, L. ; Frommer, E. ; Mallon, R. ; Tahir, A. ; Van Soest, R. ; Andersen, R. J. Scalarane-Based Sesterterpenoid Rce-Protease Inhibitors Isolated From The Indonesian Marine Sponge Carteriospongia Foliascens. Journal of Natural Products 2009, 72, 1106-1109.BibTex 2008 Volgraf, M. ; Lumb, J. P. ; Brastianos, H. C. ; Carr, G. ; Chung, M. K. W. ; Munzel, M. ; Mauk, A. G. ; Andersen, R. J. ; Trauner, D. Biomimetic Synthesis Of The Ido Inhibitors Exiguamine A And B. Nature Chemical Biology 2008, 4, 535-537.BibTex Sadar, M. D. ; Williams, D. E. ; Mawji, N. R. ; Patrick, B. O. ; Wikanta, T. ; Chasanah, E. ; Irianto, H. E. ; Van Soest, R. ; Andersen, R. J. Sintokamides A To E, Chlorinated Peptides From The Sponge Dysidea Sp That Inhibit Transactivation Of The N-Terminus Of The Androgen Receptor In Prostate Cancer Cells. Organic Letters 2008, 10, 4947-4950.BibTex Carr, G. ; Chung, M. K. W. ; Mauk, A. G. ; Andersen, R. J. Synthesis Of Indoleamine 2,3-Dioxygenase Inhibitory Analogues Of The Sponge Alkaloid Exiguamine A. Journal of Medicinal Chemistry 2008, 51, 2634-2637.BibTex Sturgeon, C. M. ; Cinel, B. ; Diaz-Marrero, A. R. ; McHardy, L. M. ; Ngo, M. ; Andersen, R. J. ; Roberge, M. Abrogation Of Ionizing Radiation-Induced G(2) Checkpoint And Inhibition Of Nuclear Export By Cryptocarya Pyrones. Cancer Chemotherapy and Pharmacology 2008, 61, 407-413.BibTex