研究领域
Analytical Chemistry; Biological & Medicinal Chemistry; Interfacial and Surface Chemistry; Materials & Polymer Chemistry
The Algar Research Group is interested in developing optically active nanoparticles as platforms for biosensing and theranostics, as well as understanding the bio/physicochemical properties of such systems.
Nanoparticles represent a new frontier for biosensing: they provide unique optoelectronic properties that are often inaccessible with bulk or molecular materials; and while sufficiently small to be used inside cells and tissues, they also provide surface area that can be chemically modified, decorated with functional biomolecules, and carry other cargoes (see illustration). Currently, our work focuses on harnessing quantum dots as a bioanalytical platform. These brightly luminescent semiconductor nanocrystals are among the most interesting and versatile nanomaterials available. We use a combination of biological, chemical, and spectroscopic tools to impart quantum dots with the ability to detect specific biomolecules and enzymatic processes.
The luminescent properties of quantum dots are ideal for multiplexing—i.e., the simultaneous detection of multiple analytes. We are working towards developing multiplexed diagnostic devices and cellular probes that can either (1) rapidly measure panels of clinically relevant biomarkers or (2) track coupled biological activity in real-time. The latter refers to biomarkers in complex signaling pathways in biological systems. Proteolytic cascades are an example in which we have a particular interest.
Some of our research projects can be loosely categorized as:
Modular, sensor-ready optical components that can be easily integrated into lab-on-a-chip systems and/or point-of-care devices.
"Smarter" cellular probes capable of multiplexed detection, or quantitative detection with a concurrent therapeutic effect.
Novel energy transfer configurations for biosensing.
Improving the affinity and selectivity of biorecognition through the use of nanoparticle scaffolds.
Students in our laboratory have the opportunity to gain experience in bioanalytical, materials, and bioconjugate chemistry, as well as fluorescence spectroscopy and imaging. Opportunities will also exist for experience in basic cell culture, manipulation, and measurements. Prospective graduate students should apply to the UBC Chemistry graduate program and contact Russ via email.
近期论文
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Petryayeva, E. ; W. Algar, R. Toward Point-Of-Care Diagnostics With Consumer Electronic Devices: The Expanding Role Of Nanoparticles. RSC Adv. 2015, 5, 22256-22282.BibTex
2014
Kim, H. ; Petryayeva, E. ; Algar, W. R. Enhancement Of Quantum Dot F #x00F6;rster Resonance Energy Transfer Within Paper Matrices And Application To Proteolytic Assays. Selected Topics in Quantum Electronics, IEEE Journal of 2014, 20, 1-11.BibTex
2013
Stewart, M. H. ; Huston, A. L. ; Scott, A. M. ; Oh, E. ; W. Algar, R. ; Deschamps, J. R. ; Susumu, K. ; Jain, V. ; Prasuhn, D. E. ; Blanco-Canosa, J. ; Dawson, P. E. ; Medintz, I. L. Competition Between Forster Resonance Energy Transfer And Electron Transfer In Stoichiometrically Assembled Semiconductor Quantum Dot-Fullerene Conjugates. ACS NANO 2013, 7, 9489-9505.BibTex
Algar, W. R. ; Medintz, I. L. Concentric Energy Transfer With Quantum Dots For Multiplexed Biosensing}. Nano Rev 2013, 4.BibTex
Spillmann, C. M. ; Ancona, M. G. ; Buckhout-White, S. ; W. Algar, R. ; Stewart, M. H. ; Susumu, K. ; Huston, A. L. ; Goldman, E. R. ; Medintz, I. L. Achieving Effective Terminal Exciton Delivery In Quantum Dot Antenna-Sensitized Multistep Dna Photonic Wires. ACS NANO 2013, 7, 7101-7118.BibTex
Petryayeva, E. ; Algar, W. R. Proteolytic Assays On Quantum-Dot-Modified Paper Substrates Using Simple Optical Readout Platforms}. Anal. Chem. 2013, 85, 8817–8825.BibTex
Anderson, G. P. ; Glaven, R. H. ; W. Algar, R. ; Susumu, K. ; Stewart, M. H. ; Medintz, I. L. ; Goldman, E. R. Single Domain Antibody-Quantum Dot Conjugates For Ricin Detection By Both Fluoroimmunoassay And Surface Plasmon Resonance. ANALYTICA CHIMICA ACTA 2013, 786, 132-138.BibTex
Algar, W. R. ; Blanco-Canosa, J. B. ; Manthe, R. L. ; Susumu, K. ; Stewart, M. H. ; Dawson, P. E. ; Medintz, I. L. Synthesizing And Modifying Peptides For Chemoselective Ligation And Assembly Into Quantum Dot-Peptide Bioconjugates}. Methods Mol. Biol. 2013, 1025, 47–73.BibTex
Boeneman, K. ; Delehanty, J. B. ; Blanco-Canosa, J. B. ; Susumu, K. ; Stewart, M. H. ; Oh, E. ; Huston, A. L. ; Dawson, G. ; Ingale, S. ; Walters, R. ; Domowicz, M. ; Deschamps, J. R. ; W. Algar, R. ; DiMaggio, S. ; Manono, J. ; Spillmann, C. M. ; Thompson, D. ; Jennings, T. L. ; Dawson, P. E. ; Medintz, I. L. Selecting Improved Peptidyl Motifs For Cytosolic Delivery Of Disparate Protein And Nanoparticle Materials. ACS NANO 2013, 7, 3778-3796.BibTex
Sapsford, K. E. ; W. Algar, R. ; Berti, L. ; Gemmill, K. Boeneman; Casey, B. J. ; Oh, E. ; Stewart, M. H. ; Medintz, I. L. Functionalizing Nanoparticles With Biological Molecules: Developing Chemistries That Facilitate Nanotechnology. CHEMICAL REVIEWS 2013, 113, 1904-2074.BibTex
Petryayeva, E. ; W. Algar, R. ; Medintz, I. L. Quantum Dots In Bioanalysis: A Review Of Applications Across Various Platforms For Fluorescence Spectroscopy And Imaging. APPLIED SPECTROSCOPY 2013, 67, 215-252.BibTex
Petryayeva, E. ; W. Algar, R. ; Krull, U. J. Adapting Fluorescence Resonance Energy Transfer With Quantum Dot Donors For Solid-Phase Hybridization Assays In Microtiter Plate Format. LANGMUIR 2013, 29, 977-987.BibTex
Buckhout-White, S. ; Spillmann, C. ; Ancona, M. ; W. Algar, R. ; Stewart, M. H. ; Susumu, K. ; Huston, A. ; Goldman, E. R. ; Medintz, I. L. Improving Energy Transfer In Qd-Dna Photonic Networks. In NANOBIOSYSTEMS: PROCESSING, CHARACTERIZATION, AND APPLICATIONS VI; Kobayashi, N. ; Ouchen, F. ; Rau, I. ; NANOBIOSYSTEMS: PROCESSING, CHARACTERIZATION, AND APPLICATIONS VI; SPIE, 2013; Vol. 8817.BibTex
Claussen, J. C. ; W. Algar, R. ; Hildebrandt, N. ; Susumu, K. ; Ancona, M. G. ; Medintz, I. L. Enhancing Molecular Logic Through Modulation Of Temporal And Spatial Constraints With Quantum Dot-Based Systems That Use Fluorescent (Forster) Resonance Energy Transfer. In NANOBIOSYSTEMS: PROCESSING, CHARACTERIZATION, AND APPLICATIONS VI; Kobayashi, N. ; Ouchen, F. ; Rau, I. ; NANOBIOSYSTEMS: PROCESSING, CHARACTERIZATION, AND APPLICATIONS VI; SPIE, 2013; Vol. 8817.BibTex
Claussen, J. C. ; W. Algar, R. ; Hildebrandt, N. ; Susumu, K. ; Ancona, M. G. ; Medintz, I. L. Biophotonic Logic Devices Based On Quantum Dots And Temporally-Staggered Forster Energy Transfer Relays. NANOSCALE 2013, 5, 12156-12170.BibTex
Delehanty, J. B. ; Spillmann, C. M. ; Naciri, J. ; W. Algar, R. ; Ratna, B. R. ; Medintz, I. L. Fluorescent Nanocolloids For Differential Labeling Of The Endocytic Pathway And Drug Delivery Applications. In COLLOIDAL NANOCRYSTALS FOR BIOMEDICAL APPLICATIONS VIII; Parak, W. J. ; Osinski, M. ; Yamamoto, K. ; COLLOIDAL NANOCRYSTALS FOR BIOMEDICAL APPLICATIONS VIII; SPIE, 2013; Vol. 8595, p. 85951E.BibTex
2012
W. Algar, R. ; Ancona, M. G. ; Malanoski, A. P. ; Susumu, K. ; Medintz, I. L. Assembly Of A Concentric Forster Resonance Energy Transfer Relay On A Quantum Dot Scaffold: Characterization And Application To Multiplexed Protease Sensing. ACS NANO 2012, 6, 11044-11058.BibTex
W. Algar, R. ; Malanoski, A. P. ; Susumu, K. ; Stewart, M. H. ; Hildebrandt, N. ; Medintz, I. L. Multiplexed Tracking Of Protease Activity Using A Single Color Of Quantum Dot Vector And A Time-Gated Forster Resonance Energy Transfer Relay. ANALYTICAL CHEMISTRY 2012, 84, 10136-10146.BibTex
Delehanty, J. B. ; Susumu, K. ; Manthe, R. L. ; W. Algar, R. ; Medintz, I. L. Active Cellular Sensing With Quantum Dots: Transitioning From Research Tool To Reality; A Review. ANALYTICA CHIMICA ACTA 2012, 750, 63-81.BibTex
W. Algar, R. ; Malonoski, A. ; Deschamps, J. R. ; Banco-Canosa, J. B. ; Susumu, K. ; Stewart, M. H. ; Johnson, B. J. ; Dawson, P. E. ; Medintz, I. L. Proteolytic Activity At Quantum Dot-Conjugates: Kinetic Analysis Reveals Enhanced Enzyme Activity And Localized Interfacial ``hopping''. NANO LETTERS 2012, 12, 3793-3802.BibTex
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