宋立兵 - 中山大学 - 肿瘤防治中心

个人简介

2001年获得中山医科大学医学博士学位。2002-2004年先后在美国麻省新英格兰医疗中心及美国芝加哥西北大学担任博士后及助理研究员，进行有关原癌基因Bmi-1在乳腺癌发生发展中生物学机制及功能的研究。目前为中山大学肿瘤防治中心-华南肿瘤学国家重点实验室独立PI，研究方向为恶性肿瘤的发病机制和早期诊断,包括探讨鼻咽癌源(干)细胞来源、鼻咽癌发生发展的病因病理及鼻咽癌、乳腺癌、食管癌的早期诊断标志物及靶位点，探索表观遗传因子遗传Bmi-1在肿瘤干细胞中的表观调节机制，原癌基因AEG-1诱导肿瘤转移的分子机制等。上述领域的工作已在Journal of clinical investigation, Cancer research, Oncogene, Clinical cancer research等SCI杂志上发表。

研究领域

1. 恶性肿瘤侵袭转移分子机制 2. 肿瘤标志物和早期诊断 3. 肿瘤分子分型和基因治疗

近期论文

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1. Liu L, Lin C, Liang W, Wu S, Liu A, Wu J, Zhang X, Ren P, Li M, Song L*. TBL1XR1 promotes lymphangiogenesis and lymphatic metastasis in esophageal squamous cell carcinoma. Gut. 2014 Mar 25. (IF: 10.372)　　2. Wang X, Lin C, Zhao X, Liu A, Zhu J, Li X, Song L*. Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor. Molecular Cancer 2014, 13:106.(IF:5.134)　　3. Chen X, Ying Z, Lin X, Lin H, Wu J, Li M, Song L*. Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells. J Clin Invest. 2013 Jun 3; 123(6):2576-89. (IF: 12.812)　　4. Liu LP, Chen K, Wu J, Shi L, Hu B, Cheng SY, Li M, Song L*. Downregulation of miR-452 Promotes Stem-like traits and Tumorigenicity of Gliomas. Clin Cancer Res. 2013 May 21. (IF: 7.837)　　5. Xie C, Wu J, Yun J, Lai J, Yuan Y, Gao Z, Li M, Li J, Song L*. MACC1 as a Prognostic Biomarker for Early-Stage and AFP-Normal Hepatocellular Carcinoma. PLoS One. 2013 May 23; 8(5):e64235. (IF: 3.73)　　6. Zeng Z, Lin H, Zhao X, Liu G, Wang X, Xu R, Chen K, Li J, Song L*. Overexpression of GOLPH3 promotes proliferation and tumorigenicity in breast 　cancer via suppression of the FOXO1 transcription factor. Clin Cancer Res. 2012 Aug 1; 18(15):4059-69. (IF: 7.837)　　7. Yu C, Zhang Z, Liao W, Zhao X, Liu L, Wu Y, Liu Z, Li Y, Zhong Y, Chen K, Li J, Zhou F*, Song L*.The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway. Carcinogenesis. 2012 Mar; 33(3): 678-86. (IF: 5.635)　　8. Li Z, Yu C, Zhong Y, Liu T, Huang Q, Zhao X, Tu H, Jiang S, Zhang Y, Liu J*, Song L*. Sam68 expression and cytoplasmic localization is correlated with lymph node metastasis as well as prognosis in patients with early-stage cervical cancer. Ann Oncol. 2012 Mar; 23(3):638-46. (IF: 7.384)　　1. C Lin, L Song, A Liu, H Gong, X Lin, J Wu, M Li and J Li. Overexpression of AKIP1 promotes angiogenesis and lymphangiogenesis in human esophageal squamous cell carcinoma. Oncogene , 13 January 2014. (IF: 7.357)　　2. Song L, Lin C, Gong H, Wang C, Liu L, Wu J, Tao S, Hu B, Cheng SY, Li M, Li J. miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops. Cell Res. 2013 Feb; 23(2):274-89. (IF: 10.526)　　3. Lin C, Song L, Gong H, Liu A, Lin X, Wu J, Li M, Li J. Nkx2-8 Downregulation Promotes Angiogenesis and Activates NF-κB in Esophageal Cancer. Cancer Res. 2013 Jun 5. (IF: 8.65)　　4. Gong H, Song L, Lin C, Liu A, Lin X, Wu J, Li M, Li J. Downregulation of miR-138 sustains NF-κB activation and promotes lipid raft formation in esophageal squamous cell carcinoma. Clin Cancer Res. 2013 Mar 1; 19(5):1083-93. (IF: 7.837)　　5. Jiang L, Song L, Wu J, Yang Y, Zhu X, Hu B, Cheng SY, Li M. Bmi-1 promotes glioma angiogenesis by activating NF-κB signaling. PLoS One. 2013; 8(1):e55527. (IF: 3.73)　　6. Song L, Liu L, Wu Z, Li Y, Ying Z, Lin C, Wu J, Hu B, Cheng SY, Li M, Li J. TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets. J Clin Invest. 2012 Oct 1; 122(10):3563-78. (IF: 12.812)　　7. Jiang L, Lin C, Song L, Wu J, Chen B, Ying Z, Fang L, Yan X, He M, Li J, Li M. MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop. J Clin Invest. 2012; 122(1):33-47. (IF: 12.812)　　8. Song L, Gong H, Lin C, Wang C, Liu L, Wu J, Li M, Li J. Flotillin-1 promotes tumor necrosis factor-α receptor signaling and activation of NF-κB in esophageal squamous cell carcinoma cells. Gastroenterology. 2012 Oct; 143(4):995-1005. (IF: 12.821)　　9. Song L, Dai T, Xie Y, Wang C, Lin C, Wu Z, Ying Z, Wu J, Li M, Li J. Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair. J Mol Cell Biol. 2012 Apr; 4(2):108-17. (IF: 7.308)　　10. Song L, Liu L, Wu Z, Lin C, Dai T, Yu C, Wang X, Wu J, Li M, Li J*. Knockdown of stomatin-like protein 2 (STOML2) reduces the invasive ability of glioma cells through inhibition of the NF-κB/MMP-9 pathway. J Pathol. 2012 Feb; 226(3):534-43. (IF: 7.585)