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个人简介

1985年本科毕业于湖南医科大学(现中南大学湘雅医学院),毕业后一直从事病理学的医教研工作,先后在中山医科大学病理教研室和香港中文大学病理学系获得硕士和博士学位。1991年入职于中山大学肿瘤医院病理科担任病理医生,1997年在香港威尔斯亲王医院进修临床病理诊断。临床医疗擅长于肿瘤病理诊断,教学主讲本科生和研究生的《肿瘤病理学》课程,科研上主要研究肿瘤发生发展的分子机制及分子分型,已获得包括5项国家自然基金在内的省部级科研项目16项。发表文章近70篇,其中以第一作者或通讯作者发表SCI文章近30篇。 学习简历:1980.9-1985.6:湖南医科大学,医学本科. 1988.9-1991.6中山医科大学病理教研室,硕士1997.1-7 香港中文大学病理学系 外科病理进修1998.3-2001.3 香港中文大学病理学系 博士 工作简历:1985.7-1988.8 湖南医科大学病理教研室任职助教1991.7-1998.3 中山大学肿瘤防治中心病理科任医师和主治医师2001.3-至今 中山大学肿瘤防治中心病理科任主治医师、副教授及教授/主任医师。

研究领域

肿瘤生物学和肿瘤分子病理学

近期论文

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1, Zhou X, Zhang CZ, Lu SX, Chen GG, Li LZ, Liu LL, Yi C, Fu J, Hu W, Wen JM, Yun JP. miR-625 suppresses tumour migration and invasion by targeting IGF2BP1 in hepatocellular carcinoma. Oncogene 2015;34:965-77. 2, Hu W, Lu SX, Li M, Zhang C, Liu LL, Fu J, Jin JT, Luo RZ, Zhang CZ, Yun JP. Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma. Oncotarget 2015;6:6570-83. 3, Zhang CZ, Fang EF, Zhang HT, Liu LL, Yun JP. Momordica charantia lectin exhibits antitumor activity towards hepatocellular carcinoma. Invest New Drugs 2015;33:1-11. 4, Li LZ, Zhang CZ, Liu LL, Yi C, Lu SX, Zhou X, Zhang ZJ, Peng YH, Yang YZ, Yun JP. miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1. Carcinogenesis 2014;35:469-78. 5, Liu LL, Lu SX, Li M, Li LZ, Fu J, Hu W, Yang YZ, Luo RZ, Zhang CZ, Yun JP. FoxD3-regulated microRNA-137 suppresses tumour growth and metastasis in human hepatocellular carcinoma by targeting AKT2. Oncotarget 2014;5:5113-24. 6, Liu LL, Zhang MF, Pan YH, Yun JP, Zhang CZ. NORE1A sensitises cancer cells to sorafenib-induced apoptosis and indicates hepatocellular carcinoma prognosis. Tumour Biol 2014;35:1763-74. 7, Liu LL, Zhang MF, Pan YH, Yun JP, Zhang CZ. NORE1A sensitises cancer cells to sorafenib-induced apoptosis and indicates hepatocellular carcinoma prognosis. Tumour Biol 2014 8, Fu J, Qiu H, Cai M, Pan Y, Cao Y, Liu L, Yun J, Zhang CZ. Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis. Cancer Sci 2013;104:508-15. 9, Yi C, Wang Q, Wang L, Huang Y, Li L, Liu L, Zhou X, Xie G, Kang T, Wang H, Zeng M, Ma J, Zeng Y, Yun JP. MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma. Oncogene 2012;31:4421-33. 10, Huang Y, Li LZ, Zhang CZ, Yi C, Liu LL, Zhou X, Xie GB, Cai MY, Li Y, Yun JP. Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis. J Transl Med 2012;10:106. 11, Cai MY, Luo RZ, Chen JW, Pei XQ, Lu JB, Hou JH, Yun JP. Overexpression of ZEB2 in peritumoral liver tissue correlates with favorable survival after curative resection of hepatocellular carcinoma. PLoS One 2012;7:e32838. 12, Wang X, Liang Y, Chen Q, Xu HM, Ge N, Luo RZ, Shao JY, He Z, Zeng YX, Kang T, Yun JP, Xie F. Prognostic significance of SOX2 expression in nasopharyngeal carcinoma. Cancer Invest 2012;30:79-85. 13, Li JD, Zhuang Y, Li YF, Feng YL, Hou JH, Chen L, Zhu AN, Wu QL, Yun JP. A clinicopathological aspect of primary small-cell carcinoma of the uterine cervix: a single-centre study of 25 cases. J Clin Pathol 2011;64:1102-7. 14, Zhang MF, Lin SX, Yi C, Fu J, Wu QL, Yun JP. Keratocystoma of the parotid gland: case report and immunohistochemical investigation. J Clin Pathol 2010;63:758-60. 15, Zhang MF, Zhang ZY, Fu J, Yang YF, Yun JP. Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma. J Transl Med 2009;7:110. 16, Xiao J, Zhang Z, Chen GG, Zhang M, Ding Y, Fu J, Li M, Yun JP. Nucleophosmin/B23 interacts with p21WAF1/CIP1 and contributes to its stability. Cell Cycle 2009;8:889-95. 17, Luo R, Zhang M, Liu L, Lu S, Zhang CZ, Yun J. Decrease of fibulin-3 in hepatocellular carcinoma indicates poor prognosis. PLoS One 2013;8:e70511. 18, Zhang CZ, Liu L, Cai M, Pan Y, Fu J, Cao Y, Yun J. Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma. PLoS One 2012;7:e51703.

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