近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
33. Shumin Ouyang, Shuo Shi, Wen Ding, Yang Ge, Yingxue Su, Jianshan Mo, Keren Peng, Qiyi Zhang, Guopin Liu, Wei Xiao, Peibin Yue, Jinjian Lu, Yandong Wang* Xiaofeng Xiong,* and Xiaolei Zhang*, Neuropeptide Precursor VGF Promotes Liver Metastatic Colonization of G𝜶q Mutant Uveal Melanoma by Facilitating Tumor Microenvironment via Paracrine Loops, Adv Sci, 2024, 2407967.
32. Guangjin Fan; Lu Liu; Jia Ye; Wei Xiao; Xiao-Feng Xiong, Design, synthesis and evaluation of quinazoline derivatives as Gαq/11 proteins inhibitors against uveal melanoma, Bioorganic Chemistry, 2024, 143, 107005.
31. Lu Liu; Zhendong Song; Guangjin Fan; Linlin Lou; Yuanxiang Wang; Xiaolei Zhang; Xiao-Feng Xiong, Discovery of novel indazole derivatives as SOS1 agonists that activate KRAS signaling, Bioorganic & Medicinal Chemistry, 2023, 93, 117457.
30. Zhendong Song, Linlin Lou; Guangjin Fan; Lu Liu; Yang Ge; He Liu; Albert S.C. Chan; Xiaolei Zhang; Xiao-Feng Xiong, Identification of novel Pyrrolo[2,3-d]Pyrimidine-based KRAS G12C inhibitors with anticancer effects, European Journal of Medicinal Chemistry, 2023, 245, 114907.
29. Qi-Long Hu, Jia-Tian Liu, Guangjin Fan, Jian Li, Hu, QL;Liu, JT;Fan, GJ;Li, J;Li, YX;Chan, ASC; Xiong, XF, On-resin peptide modification of methionine residue by employing 2-bromoacetate derivatives, Chin Chem Lett, 2023, 34, 198-202.
28. Feng Zhou, Qi-Long Hu, Ke-Qiang Hou,* Hu, QL;Liu, JT;Fan, GJ;Li, J;Li, YX;Chan, ASC;Xiong, XF*, Construction of α,β-Diamino Diacid Derivatives with Adjacent Acyclic Tetrasubstituted Stereocenters, J. Org. Chem., 2022,87, 8709-8718.
27. Feng Zhou, Yue Huang, Lu Liu, Zhendong Song, Ke-Qiang Hou, Yifan Yang, Hai-Bin Luo, Yi-You Huang*, Xiao-Feng Xiong*, Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects, Biochemical Pharmacology, 2022, 202, 115123.
26. Jun-Jie Deng , Lu Liu , Yang Ge, Zhendong Song Jie Huang, Guangjin Fan Xiao-Feng Xiong*, Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule Gαq/11 inhibitors against uveal melanoma, Eur. J. Med. Chem, 2022, 239, 114520.
25. Yang Ge, Jun-Jie Deng, Jianzheng Zhu, Lu Liu, Shumin Ouyang, Zhendong Song, Xiaolei Zhang*, Xiao-Feng Xiong*, Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma, Acta Pharmaceutica Sinica B, 2022, 12, 3326-3340.
24. Jian Li, Qi-Long Hu, Zhendong Song, Albert S. C. Chan*, Xiao-Feng Xiong*, Cleavable Cys labeling directed Lys-site-selective stapling and single-site modification, Sci. Chin. Chem, 2022, 65, 1356-1361.
23. Zhendong Song, Yi-You Huang, Ke-Qiang Hou, Lu Liu, Feng Zhou, Yue Huang, Guohui Wan, Hai-Bin Luo,* and Xiao-Feng Xiong*, Discovery and structural optimization of Toddacoumalone derivatives as novel PDE4 Inhibitors for the topical treatment of Psoriasis, J. Med. Chem. 2022, 65, 4238−4254.
22. Jian Li, Weihong Lai, Ao Pang, Lu Liu, Lianbao Ye, Xiao-Feng Xiong*, On-resin synthesis of linear aryl thioether containing peptides and in-solution cyclization via cysteine S N Ar reaction, Organic Letters, 2022, 24, 1673-1677.
21. Guangjin Fan, Linlin Lou, Zhendong Song*, Xiaolei Zhang*, Xiao-Feng Xiong*, Targeting mutated GTPase KRAS in tumor therapies, Eur. J. Med. Chem, 2021, 226, 113816.
20. Qi-Long Hu, Jia-Tian Liu, Jian Li, Yang Ge, Zhendong Song, Albert S. C. Chan; Xiao-Feng Xiong*, Demethylative alkylation of methionine residue by employing the sulfonium as the key intermediate, Organic Letters, 2021, 23: 8543-8548
19. Yang Ge,§ Shuo Shi,§ Jun-Jie Deng, Xue-Ping Chen, Zhendong Song, Lu Liu, Linlin Lou, Xiaolei Zhang,* Xiao-Feng Xiong*, Design, Synthesis and Evaluation of Small Molecule Gαq/11 Protein Inhibitors for the Treatment of Uveal Melanoma, J. Med. Chem. 2021, 64, 3131-3152.
18. Jian Li, Jun-Jie Deng, Zhibin Yin, Qi-Long Hu, Yang Ge, Zhen-Dong Song, Ying Zhang, Albert S. C. Chan, Huilin Li, and Xiao-Feng Xiong*, Cleavable and Tunable Cysteine-Specific Arylation Modification by Aryl Thioethers, Chemical Science, 2021, 12, 5209-5215.
17. Xue-Ping Chen, Ke-Qiang Hou, Feng Zhou, Albert S. C. Chan, and Xiao-Feng Xiong*, Organocatalytic Asymmetric Synthesis of Benzothiazolopyrimidines via [4 + 2] Cyclization of 2‑Benzothiazolimines and Aldehydes, J. Org. Chem., 2021, 86, 1667-1675.
16. Zhen-Dong Song, Mei-Jing Wang, Yang Ge, Xue-Ping Chen, Zi-Yang Xu, Yang Sun*, Xiao-Feng Xiong*, Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies, Acta Pharmaceutica Sinica B, 2021, 11, 13-29.
15. Ke-Qiang Hou, Feng Zhou, Xue-Ping Chen, Yang Ge, Albert S.C. Chan and Xiao-Feng Xiong*, Asymmetric Synthesis of Oxindole-Derived Vicinal Tetrasubstituted Acyclic Amino Acid Derivatives by Mannich-Type Reaction, J. Org. Chem., 2020, 85, 9661-9667.
14. Qi-Long Hu, Ke-Qiang Hou, Jian Li, Yang Ge, Zhen-Dong Song, Albert S.C. Chan and Xiao-Feng Xiong*, Silanol: A bifunctional group for peptide synthesis and late-stage functionalization, Chemical Science, 2020, 11, 6070-6074。
13. Jun-Xiang Huang, Ke-Qiang Hou, Qi-Long Hu, Xue-Ping Chen, Jian Li, Albert S. C. Chan, and Xiao-Feng Xiong*, Organo-catalytic Asymmetric Three-component Povarov Reactions of Anilines and Aldehydes, Organic Letters, 2020, 22, 1858-1862.
12. Ke-Qiang Hou, Xue-Ping Chen, Yiyou Huang, Albert S. C. Chan, Hai-Bin Luo, Xiao-Feng Xiong*, Asymmetric total synthesis and biological evaluation of the nutural PDE4 inhibitor toddacoumalone. Organic Letters, 2020, 22, 584-588.
11. Jian Li, Qi-Long Hu, Xue-Ping Chen, Ke-Qiang Hou, Albert S.C. Chan*, Xiao-Feng Xiong*, Asymmetric synthesis of tetrahydropyran[3,2-c]quinolinones via an organocatalyzed formal [3+3] annulation of quinolinones and MBH 2-naphthoates of nitroolefifin, Chin. Chem. Lett., 2020, 21, 697-670.
10. Jian Li, Yang Ge, Jun-Xiang Huang, Kristian Strømgaard, Xiaolei Zhang, Xiao-Feng Xiong*,, Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery, J. Med. Chem. 2020, 63, 5013-5020.
9. Xiao-Feng Xiong, Hang Zhang, Michael W. Boesgaard, Christina R. Underwood, Hans Bräuner-Osborne, Kristian Strømgaard, Structure-activity relationship study of natural Gq protein inhibitor YM-254890, ChemMedChem, 2019, 14, 865-870.
8. Xiao-Feng Xiong, Hang Zhang, Christina R. Underwood, Kasper Harpsøe, Thomas J. Gardella, Mie F. Wöldike, Micheal Mannstadt, David. E. Gloriam, Hans Bräuner-Osore, Kristian Strømgaard. “Total synthesis and structure-activity relationship study of a series of selective Gq protein inhibiotrs “. Nature Chemistry. 2016, 8, 1035-1041.
7. Xiao-Feng Xiong, Mette H. Poulsen, Rama Ashraf, Niels G. Nørager, Kristian Strømgaard, “Structure-activity relationship study of spider polyamine toxins as inhibitors of ionotropic glutamate receptors“. ChemMedChem, 2014, 9, 2661-2670. 封面文章
6. Xiao-Feng Xiong, Quan Zhou, Jing Gu, Lin Dong, Tan-Yu Liu, Ying-Chun Chen, “Trienamine Catalysis with 2,4-Dienones: Development and Application in Asymmetric Diels-Alder Reaction”, Angew. Chem. Int. Ed. 2012, 51, 4401-4404. VIP及封面文章
5. Xiao-Feng Xiong, Hang Zhang, Jing Peng, and Ying-Chun Chen, “Direct Asymmetric Michael Addition of cyclic N-sulfonylimines to α,β-Unsaturated Aldehydes”, Chem. Eur. J. 2011, 17, 2358-2360.
4. Xiao-Feng Xiong, Zhi-Jun Jia, Wei Du, Kun Jiang, Tian-Yu liu, Ying-Chun Chen, “Merging chiral organocatalysts: enantio- and diastereoselective directvinylogous Mannich reaction of alkylimines”, Chem. Commun. 2009, 6994-6996.
3. Kelly L Roszko, Bi Ruiye, Caroline Gorvin, Hans Bräuner-Osborne, Xiao-Feng Xiong, Asuka Inoue, Rajesh V Thakker, Kristian Strømgaard, Thomas Gardella, Michael Mannstadt, "Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors", JCI Insight, 2017, 2(3):e91079. doi:10.1172/jci.insight.91079
2. Hang Zhang, Xiao-Feng Xiong, Michael W. Boesgaard, Christina R. Underwood, Hans Bruner-Osborne, and Kristian Strømgaard. "Structure–Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein", ChemMedChem, 2017, DOI: 10.1002/cmdc.201700155.
1. Bo Han, Qing-Ping Liu, Rui Li, Xu Tian, Xiao-Feng Xiong, Jing-Gen Deng, Ying-Chun Chen, “Discovery of Bifunctional Thiourea/Secondary-Amine Organocatalysts for the Highly Stereoselective Nitro-Mannich Reaction of α-Substituted Nitroacetates”, Chem. Eur. J. 2008，14 , 8094-8097.
京公网安备 11010802027423号