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个人简介

教育背景 2008.9-2014.12 博士 厦门大学 2012.8-2013.3 访问学者 哈佛大学医学院 2004.9-2008.7 学士 福州大学 工作经历 2021.9-至今 博士生导师 厦门大学公共卫生学院 2020.8-至今 副教授 厦门大学公共卫生学院 2015.7-2020.7 助理教授 厦门大学公共卫生学院 授权专利 1.国家发明专利,一种重组单纯疱疹病毒及其用途,ZL 201810165563.4,2022/8,第一发明人 2.美国发明专利,RECOMBINANT HERPES SIMPLEX VIRUS AND USE THEREOF,US11,680,248,2023/7,第一发明人 3.国家发明专利,抗PD-1抗体及其用途,ZL 201910654839.X,2021/12,第一发明人 主持课题 1.国家自然科学基金面上项目,82373286,靶向抑制富亮氨酸重复激酶2消除胶质母细胞瘤对溶瘤疱疹病毒抵抗性的作用及其机制研究,2024/01-2027/12,在研,主持 2.国家科技重大专项,2018ZX10301404-001,HBV特异性B细胞应答规律及抗体基因克隆,2018/01-2021/06,已结题,子课题负责人,主持 3.国家自然科学基金面上项目,81571990,HBx BH3结构域在HBV复制和肝癌转化中的作用及机制研究,2016/01-2019/12,已结题,主持 获奖 厦门市科学技术进步一等奖(2014年)、福建省科学技术进步二等奖(2017年)

研究领域

溶瘤病毒与肿瘤治疗 肿瘤的免疫调节及免疫治疗研究 肿瘤致癌机制研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Ren, W. * , Xu, Z. * , Chang, Y. * , Ju, F. * , Wu, H. * , Liang, Z. * , Zhao, M., Wang, N., Lin, Y., Xu, C., Chen, S., Rao, Y., Lin, C., Yang, J, Liu, P. # , Zhang, J. # , Huang, C. # & Xia, N. # Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1. Nature Communication s 15, 9, doi: 10.1038/s41467-023-44466-7 (2024).( # 共通讯作者) 2. Lin, C. * , Teng, W. * , Tian, Y. * , Li, S., Xia, N. # & Huang, C. # The immune landscape and response to oncolytic virus-based immunotherapy. Frontiers of Medicine , https://doi.org/10.1007/s11684-023-1048-0 (2024). ( # 共通讯作者) 3. Wang, G. * , Cao, J. * , Gui, M. * , Huang, P. * , Zhang, L. * , Qi, R., Chen, R., Lin, L., Han, Q., Lin, Y., Chen, T., He, P., Ma, J., Fu, R., Hong, J., Wu, Q., Yu, H., Chen, J., Huang, C. # , Zhang, T. # , Yuan, Q. # , Zhang, J. # , Chen, Y. # & Xia, N. # The potential of swine pseudorabies virus attenuated vaccine for oncolytic therapy against malignant tumors. J Exp Clin Cancer Res 42, 284, doi:10.1186/s13046-023-02848-1 (2023).( # 共通讯作者) 4. Tian, R. * , Ju, F. * , Yu, M. * , Liang, Z., Xu, Z., Zhao, M., Qin, Y., Lin, Y., Huang, X., Chang, Y., Li, S., Ren, W., Lin, C., Xia, N. & Huang, C. # A potent neutralizing and protective antibody against a conserved continuous epitope on HSV glycoprotein D. Antiviral Res 201, 105298, doi:10.1016/j.antiviral.2022.105298 (2022).( # 通讯作者) 5. Ju, F. * , Luo, Y. * , Lin, C. * , Jia, X. * , Xu, Z., Tian, R., Lin, Y., Zhao, M., Chang, Y., Huang, X., Li, S., Ren, W., Qin, Y., Yu, M., Jia, J., Han, J., Luo, W., Zhang, J., Fu, G. # , Ye, X. # , Huang, C. # & Xia, N. # Oncolytic virus expressing PD-1 inhibitors activates a collaborative intratumoral immune response to control tumor and synergizes with CTLA-4 or TIM-3 blockade. J Immunother Cancer 10, doi:10.1136/jitc-2022-004762 (2022).( # 共通讯作者) 6. Luo, Y. * , Lin, C. * , Zou, Y., Ju, F., Ren, W., Lin, Y., Wang, Y., Huang, X., Liu, H., Yu, Z., Liu, P., Tan, G., Yuan, Q., Zhang, J., Huang, C. # & Xia, N. # Tumor-targeting oncolytic virus elicits potent immunotherapeutic vaccine responses to tumor antigens. Oncoimmunology 9, 1726168, doi:10.1080/2162402X.2020.1726168 (2020).( # 共通讯作者) 7. Lin, C. * , Ren, W. * , Luo, Y., Li, S., Chang, Y., Li, L., Xiong, D., Huang, X., Xu, Z., Yu, Z., Wang, Y., Zhang, J., Huang, C. # & Xia, N. # Intratumoral Delivery of a PD-1-blocking scFv encoded in Oncolytic HSV-1 Promotes Antitumor Immunity and Synergizes with TIGIT Blockade. Cancer Immunol Res , doi:10.1158/2326-6066.CIR-19-0628 (2020).( # 共通讯作者) 8. Lin, C., Li, H., Hao, M., Xiong, D., Luo, Y., Huang, C. # , Yuan, Q., Zhang, J. & Xia, N. # Increasing the Efficiency of CRISPR/Cas9-mediated Precise Genome Editing of HSV-1 Virus in Human Cells. Sci Rep 6, 34531, doi:10.1038/srep34531 (2016).( # 共通讯作者) 9. Huang, C. H. * , Yuan, Q. * , Chen, P. J., Zhang, Y. L., Chen, C. R., Zheng, Q. B., Yeh, S. H., Yu, H., Xue, Y., Chen, Y. X., Liu, P. G., Ge, S. X., Zhang, J. # & Xia, N. S. # Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors. J Hepatol 57, 720-729, doi:10.1016/j.jhep.2012.05.009 (2012).( * 共第一作者) 10. Geng, X. * , Huang, C. * , Qin, Y., McCombs, J. E., Yuan, Q., Harry, B. L., Palmer, A. E., Xia, N. S. # & Xue, D. # Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction. Proc Natl Acad Sci U S A 109, 18471-18476, doi:10.1073/pnas.1204668109 (2012).( * 共第一作者)

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