陈毅歆 - 厦门大学 - 公共卫生学院

个人简介

1999，福州大学生工系，学士 2005，厦门大学生命科学学院，硕士 2008，厦门大学生命科学学院，博士 2009，厦门大学生命科学学院，公共卫生学院，助理教授 2014，厦门大学生命科学学院，公共卫生学院，副教授

研究领域

针对人类病毒性传染病的病原体开展分子病毒学与免疫学研究，主要涉及流感病毒、肠道病毒和Epstein-Barr病毒等病原体。重点研究病原体靶标蛋白的抗原性变异规律、表位特征及生物学功能等，为研制病原体的诊断试剂、治疗性抗体药物和疫苗提供支持，在广谱免疫策略和广谱治疗性抗体筛选方面有独到经验。

近期论文

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(1)Chen Y, Chan, KH, Kang Y,Chen H, Luk HK, Poon RW, Chan JF, Yuen KY, Xia N, Lau SK and Woo PC. Asensitive and specific antigen detection assay for Middle East respiratorysyndrome coronavirus. Emerging Microbes & Infections,2015,4,e26. ( http://news.xmu.edu.cn/s/13/t/542/85/c7/info165319.htm) (2)Gui X,Li R, Zhang X, Shen C, Yu H, Guo X, Kang Y, Chen J, Chen H, Chen Y*, Xia N*. An important amino acid in nucleoprotein contributes toinfluenza A virus replication by interacting with polymerase PB2. Virology,2014,464-465:11-20. (3)Gui X,Ge P, Wang X, Yang K, Yu H, Zhao Q, ChenY*, Xia N*. Identification of ahighly conserved and surface exposed B-cell epitope on the nucleoprotein ofinfluenza A virus. Journal of Medical Virology,2014,86:995-1002. (4)Chen Y #, Li C #,He D, Cheng T, Ge S, Shih JW, Zhao Q, Chen P-J, Zhang J, Xia N. Antigenicanalysis of divergent genotypes human Enterovirus 71 viruses by a panel ofneutralizing monoclonal antibodies: Current genotyping of EV71 does not reflecttheir antigenicity. Vaccine,2013,31:425-30. (5)Wu WL,Lau SY, Chen Y, Wang G, Mok BW, WenX, Wang P, Song W, Lin T, Chan KH, Yuen KY, Chen H. The 2008-2009 H1N1influenza virus exhibits reduced susceptibility to antibody inhibition:Implications for the prevalence of oseltamivir resistant variant viruses. AntiviralResearch,2012,93:144-153. (6)Chen Y #, ZhengQ#, Yang K, Zen F, LauS-Y, Wu WL, Huang S, Zhang J, Chen H, Xia N. Serological survey of antibodiesto influenza A viruses on a group of people without a history of influenzavaccination.Clinical Microbiologyand Infection,2011,17:1347-1349. (7)ZhengQ, Xia L, Wu WL, Zheng Z, Huo Y, Wu J, Liu Y, Yu H, Chen Y, Lau SY, Chen H, Luo W, Xia N. Properties and therapeuticefficacy of broadly reactive chimeric and humanized H5-specific monoclonalantibodies against H5N1 influenza viruses. Antimicrobial Agents and Chemotherapy,2011,55:1349-1357. (8)Chen Y, Xu F, Gui X,Yang K, Wu X, Zheng Q, Ge S, Yuan Q, Yeo AET, Zhang J, Guan Y, Chen H, Xia N. Arapid test for the detection of influenza A virus including pandemic influenzaA/H1N1 2009.Journal of Virological Methods, 2009,167:100-102. (9)Chen Y #, Qin K#, Wu WL, Li G, Zhang J, DuH, Ng MH, Shih JWK, Peiris JSM, Guan Y, Chen H, and Xia N. BroadCross-Protection against H5N1 Avian Influenza Virus Infection by Means ofMonoclonal Antibodies that Map to Conserved Viral Epitopes.Journal of Infectious Diseases,2009,199:49-58. (10)WL Wu#, Chen Y #, Wang P, Song W, Lau SY, Rayner JM, Smith GJD,Webster RG, Peiris JSM, Lin T, Xia N, Guan Y and Chen H. Antigenic profile ofavian H5N1 viruses in Asia from 2002 to 2007.Journal of Virology, 2008,82:1798-1807. (11)Chen Y, F Xu, X Fan, HLuo, S Ge, Q Zheng, N Xia, H Chen, Y Guan, and J Zhang. Evaluation of a rapidtest for detection of H5N1 avian influenza virus. Journal of Virological Methods,2008,154:213-215.