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个人简介

EDUCATION 2003-2007 Bachelor of Science, College of Chemistry, Nankai University, Tianjin, China. Research Advisor (2005-2006): Professor Qi-Lin Zhou. Research Topic: Asymmetric Hydrogenation of Simple Ketones Catalyzed by Chiral Spiro Phosphines-Ligated Ruthenium Complexes. During 2006-2007, Studied in the National University of Singapore as an exchange student. 2007-2012 Doctor of Philosophy, Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, United States. Research Advisor: Professor Michael P. Doyle Research Topic: Asymmetric Catalysis with Metal Carbenes and Lewis Acids; Structural Design and Chemistry of Dirhodium Carboxamidates WORK EXPERIENCE 2012-2015 Postdoctoral Scholar, Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States. Research Advisor: Professor Jin-Quan Yu. Research Topic: Palladium-Catalyzed C-H Functionalizations. 2015-present Professor (tenure-track), State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China HONORS AND AWARDS HuangYaoZeng Organometallic Young Investigator Award, 2021. Thieme Chemistry Journals Award, 2021. Xplorer Prize, 2019. ACP Lectureship Award, Singapore, 2018. Research of Excellence Award, University of Maryland, 2012. Millard and Lee Alexander Graduate Fellowship in Chemistry, University of Maryland, 2012.

研究领域

Our group is centered on the development of new catalytic methods that would allow efficient synthesis of polyfunctional organic compounds. The catalysts we were particularly interested in are boranes (organoborons). Research projects are directed towards the following aspects: new synthetic methods, asymmetric catalysis, activation of inert chemical bonds (C–H and C–C activations), and synthetic applications in pharmaceutical science and material science. Ultimately, we hope to develop highly practical and effective catalytic reactions that are desirable for both academia and industry.

近期论文

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Ming Zhang, Zi-Lu Tang, Heng Luo, Xiao-Chen Wang* β-C–H Allylation of Trialkylamines with Allenes Promoted by Synergistic Borane/Palladium Catalysis Angew. Chem. Int. Ed. 2023, e202317610 Jun-Jie Tian,# Rui-Rui Li,# Gui-Xiu Tian, Xiao-Chen Wang*Enantioselective C3-Allylation of Pyridines via Tandem Borane and Palladium Catalysis Angew. Chem. Int. Ed. 2023, e202307697 Zhong Liu, #Zhu-Jun Shi,# Lu Liu, Ming Zhang, Meng-Chen Zhang Hao-Yang Guo, and Xiao-Chen Wang* Asymmetric C3-Allylation of Pyridines J. Am. Chem. Soc. 2023 Ming Zhang, Qingyang Zhou, Heng Luo, Zi-Lu Tang, Xiufang Xu*, Xiao-Chen Wang* C3-Cyanation of Pyridines: Constraints on Electrophiles and Determinants of Regioselectivity Angew. Chem. Int. Ed. 2023, e202216894 Xin-Yue Zhou, Ming Zhang, Zhong Liu, Jia-Hao He, Xiao-Chen Wang* C3-Selective Trifluoromethylthiolation and Difluoromethylthiolation of Pyridines and Pyridine Drugs via Dihydropyridine Intermediates J. Am. Chem. Soc. 2022, 144, 14463–14470 Jun-Jie Tian,Wei Sun,Rui-Rui Li,Gui-Xiu Tian,Xiao-Chen Wang* Borane/Gold(I)-Catalyzed C–H Functionalization Reactions and Cycloaddition Reactions of Amines and α-Alkynylenones Angew. Chem. Int. Ed. 2022, 61, e202208427 Xin-Shen Liang,# Rui-Dong Li,# Wei Sun, Zhong Liu, and Xiao-Chen Wang* Coupling of 2H-Chromenes with Silyl Ketene Acetals Enabled by Borane Catalysis ACS. Catal. 2022, 12, 9153-9158 Zhong Liu,# Jia-Hao He,# Ming Zhang, Zhu-Jun Shi, Han Tang, Xin-Yue Zhou, Jun-Jie Tian, Xiao-Chen Wang* Borane-Catalyzed C3-Alkylation of Pyridines with Imines, Aldehydes, or Ketones as Electrophiles J. Am. Chem. Soc. 2022, 144 ,4810–4818 Zhao-Ying Yang, Ming Zhang, and Xiao-Chen Wang* Synthesis and Applications of Chiral Bicyclic Bisborane Catalysts Synthesis 2022, 54(06): 1527-1536 Zhao-Ying Yang, Heng Luo, Ming Zhang, and Xiao-Chen Wang* Borane-Catalyzed Reduction of Pyridines via a Hydroboration/Hydrogenation Cascade ACS Catal. 2021, 11, 10824−10829 Ming Zhang, and Xiao-Chen Wang* Bifunctional Borane Catalysis of a Hydride Transfer/Enantioselective [2+2] Cycloaddition Cascade Angew. Chem. Int. Ed. 2021, 60, 17185-17190 Zi-Yu Zhang, Jie Ren, Ming Zhang, Xiu-Fang Xu, Xiao-Chen Wang* Divergent Synthesis of N-Heterocycles by Merging Borane-Mediated Cyclopropane Ring-Opening and Hydride Abstraction Chin. J. Chem. 2021, 39, 1641-1645. Jun-Jie Tian,# Ning Liu,# Qi-Fei Liu, Wei Sun, and Xiao-Chen Wang* Borane-Catalyzed Direct Asymmetric Vinylogous Mannich Reactions of Acyclic α,β-Unsaturated Ketones J. Am. Chem. Soc. 2021, 143, 3054-3059. Zhong Liu, Xian-Shuang Tu, Le-Tao Guo and Xiao-Chen Wang* Aluminum–Catalyzed Tunable Halodefluorination of Trifluoromethyl- and Difluoroalkyl-Substituted Olefins Chem. Sci. 2020, 11, 11548–11553. Ya-Lin Zhang, Rui-Ting Guo, Heng Luo, Xin-Shen Liang, and Xiao-Chen Wang* Convergent Synthesis of Dihydropyrans from Catalytic ThreeComponent Reactions of Vinylcyclopropanes, Diazoesters, and Diphenyl Sulfoxide Org. Lett. 2020, 22, 5627-5632. Jun-Jie Tian,# Zhao-Ying Yang,# Xin-Shen Liang, Ning Liu, Chen-Yu Hu, Xian-Shuang Tu, Xiang Li, and Xiao-Chen Wang* Borane-Catalyzed Chemoselective and Enantioselective Reduction of 2-Vinyl-Substituted Pyridines Angew. Chem. Int. Ed., 2020, 59, 18452-18456. Rui-Ting Guo, Ya-Lin Zhang, Jun-Jie Tian, Ke-Yu Zhu and Xiao-Chen Wang* Rhodium-Catalyzed ortho-Selective Carbene C–H Insertion of Unprotected Phenols Directed by a Transient Oxonium Ylide Intermediate Org. Lett. 2020, 22, 908-913 Yu-Quan Zhao, Jun-Jie Tian, Chong-Ren Ai and Xiao-Chen Wang* Diiodomethane-Mediated Generation of N-Aryliminium Ions and Subsequent [4 + 2] Cycloadditions with Olefins J. Org. Chem. 2020, 85, 2456-2465 Zhi-Yun Liu,# Ming Zhang,#and Xiao-Chen Wang* Hydrosilylation-Promoted Furan Diels–Alder Cycloadditions with Stereoselectivity Controlled by the Silyl Group J. Am. Chem. Soc. 2020, 142, 581-588 Jun-Jie Tian#, Ning-Ning Zeng#, Ning Liu, Xian-Shuang Tu, and Xiao-Chen Wang* Intramolecular Cyclizations of Vinyl-Substituted N,N-Dialkyl Arylamines Enabled by Borane-Assisted Hydride Transfer ACS Catal. 2019, 9, 295-300. Xin-Shen Liang, Rui-Dong Li, and Xiao-Chen Wang* Copper-Catalyzed Asymmetric Annulation Reactions of Carbenes with 2-Iminyl- or 2-Acyl-Substituted Phenols: Convenient Access to Enantioenriched 2,3-Dihydrobenzofurans Angew. Chem. Int. Ed. 2019, 58, 13885 –13889 Ya-Lin Zhang,# Rui-Ting Guo,#Jia-Hao He, and Xiao-Chen Wang* Catalytic Intermolecular Coupling of Rhodacyclopentanones with Alcohols Enabled by Dual Directing Strategy Org. Lett. 2019, 21, 4239-4244 Xiang Li,#Jun-Jie Tian,# Ning Liu, Xian-Shuang Tu, Ning-Ning Zeng, and Xiao-Chen Wang* Spiro Bicyclic Bisborane Catalysts for Metal-Free Chemoselective and Enantioselective Hydrogenation of Quinolines Angew. Chem. Int. Ed. 2019, 58, 4664-4668. Xian-Shuang Tu, Ning-Ning Zeng, Ru-Ye Li, Yu-Quan Zhao, De-Zhen Xie, Qian Peng* and Xiao-Chen Wang* C2-Symmetric Bicyclic Bis-Borane Catalysts: Kinetic or Thermodynamic Products from a Reversible Hydroboration of Dienes Angew. Chem. Int. Ed. 2018, 57, 15096-15100. Zi-Yu Zhang,# Zhi-Yun Liu,# Rui-Ting Guo, Yu-Quan Zhao, Xiang Li, and Xiao-Chen Wang* B(C6F5)3-Catalyzed Ring Opening and Isomerization of Unactivated Cyclopropanes Angew. Chem. Int. Ed. 2017, 56, 4028-4032 Zhi-Yun Liu, Zhi-Hui Wen, and Xiao-Chen Wang* B(C6F5)3-Catalyzed Cascade Reduction of Pyridines Angew. Chem. Int. Ed. 2017, 56, 5817-5820 Brandon E. Haines, Xiao-Chen Wang, Jin-Quan Yu and Djamaladdin G. Musaev Mechanistic Details of the Pd(II)-Catalyzed C-H Iodination by Iodine Molecule: Oxidative Addition vs Electrophilic Cleavage. J. Am. Chem. Soc. 2015, 137, 9022. Xiao-Chen Wang, Wei Gong, Li-Zhen Fang, Ru-Yi Zhu, Suhua Li, Keary M. Engle and Jin-Quan Yu Ligand-enabled meta-C-H activation using a transient mediator. Nature 2015, 519, 334.

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