Elcock, Adrian - University of Iowa - Department of Biochemistry

个人简介

Education BSc, Department of Chemistry, University of East Anglia DrPH, Department of Chemistry, Oxford University Fellow, Department of Chemistry and Biochemistry, University of California, San Diego

研究领域

Work in my laboratory focuses on using molecular simulation techniques to address a variety of fundamental biophysical questions. Research areas in which we have recently published work include: (1) simulation of diffusion and association of proteins in highly concentrated solutions (such as those that are found inside living cells), (2) simulation of amino acid associations at the very high temperatures encountered by hyperthermophilic organisms, (3) computational prediction of drug-receptor interactions, with a view to identifying all cellular targets of current anti-cancer drugs, and (4) computational prediction of functionally important residues in proteins given only the protein's structure. Other research areas that we have recently developed interests in include: (1) computational identification of cryptic binding sites in proteins that might be used to develop novel inhibitors, (2) molecular simulations of protein folding in physiological conditions (including the effects of chaperonins), (3) modeling the role of conformational flexibility in protein-protein association events, and (4) experimentally measuring the affinities of drug-receptor interactions to provide reliable data for testing our computational methods. Students in my laboratory come from a wide range of backgrounds, and do not have to be experts in the use of computers: most of our work involves developing ideas in our heads, and computer simulations are typically only used to test these ideas. To complement our simulation work, we will in the near future also be increasingly conducting our own experiments: students joining my laboratory will therefore have the opportunity to undertake combined theoretical and experimental research projects.

近期论文

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Miller, M. S., Lay, W. K. & Elcock, A. H. (2016). Osmotic Pressure Simulations of Amino Acids and Peptides Highlight Potential Routes to Protein Force Field Parameterization.. The journal of physical chemistry. B, 120(33), 8217-29. DOI: 10.1021/acs.jpcb.6b01902. Lay, W. K., Miller, M. S. & Elcock, A. H. (2016). Optimizing Solute-Solute Interactions in the GLYCAM06 and CHARMM36 Carbohydrate Force Fields Using Osmotic Pressure Measurements.. Journal of chemical theory and computation, 12(4), 1401-7. DOI: 10.1021/acs.jctc.5b01136. Clark, P. L., Elcock, A. H. (2016). Molecular chaperones: providing a safe place to weather a midlife protein-folding crisis.. Nature structural & molecular biology, 23(7), 621-3. DOI: 10.1038/nsmb.3255. Chen, R., Subramanyam, S., Elcock, A. H., Spies, M. & Wold, M. S. (2016). Dynamic binding of replication protein a is required for DNA repair.. Nucleic acids research, 44(12), 5758-72. DOI: 10.1093/nar/gkw339. Li, S., Andrews, C. T., Frembgen-Kesner, T., Miller, M. S., Siemonsma, S. L., Collingsworth, T. D., Rockafellow, I. T., Ngo, N. A., Campbell, B. A., Brown, R. F., Guo, C., Schrodt, M., Liu, Y. T. & Elcock, A. H. (2015). Molecular Dynamics Simulations of 441 Two-Residue Peptides in Aqueous Solution: Conformational Preferences and Neighboring Residue Effects with the Amber ff99SB-ildn-NMR Force Field.. Journal of chemical theory and computation, 11(3), 1315-29. DOI: 10.1021/ct5010966. Brown, R. F., Andrews, C. T. & Elcock, A. H. (2015). Stacking Free Energies of All DNA and RNA Nucleoside Pairs and Dinucleoside-Monophosphates Computed Using Recently Revised AMBER Parameters and Compared with Experiment.. Journal of chemical theory and computation, 11(5), 2315-28. DOI: 10.1021/ct501170h. Li, S., Elcock, A. H. (2015). Residue-Specific Force Field (RSFF2) Improves the Modeling of Conformational Behavior of Peptides and Proteins.. The journal of physical chemistry letters, 6(11), 2127-33. DOI: 10.1021/acs.jpclett.5b00654.