Baker, Sheila - University of Iowa - Department of Biochemistry

个人简介

Education BS, Biology, University of Wisconsin, Stevens Point PhD, Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin Post Doctoral Fellow, Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School Post Doctoral Fellow, Ophthalmology, Albert Eye Research Institute, Duke University

研究领域

Our vision has such a large dynamic range that we can adjust to see under the glaring light of high noon to traverse a desert or detect the small scattering of photons that reach our eye after traveling for 2.5 million light-years from the Andromeda Galaxy. How is this possible? One part of the answer to that question lies in the cellular organization of our photoreceptors where a division of labor ensures optimal function. The phototransduction cascade, one of the best studied G-protein signaling pathways, is confined to the membrane discs of the outer segment; while energy production, metabolism, lipid and protein synthesis are confined to the inner segment. Distinct from the outer or inner segment, the ribbon synapse is where communication to downstream neurons in the retina is regulated. We study how various proteins are trafficked to, and organized within, these compartments using mouse or frog photoreceptors as our model systems. By gaining insight into the interplay between the regulated trafficking of different proteins and the development and health of photoreceptors the vision research community will be better positioned to combat blindness. Please contact us if you have questions about our current projects.

近期论文

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Laird, J. G., Pan, Y., Modestou, M., Yamaguchi, D. M., Song, H., Sokolov, M. & Baker, S. A. (2015). Identification of a VxP targeting signal in the flagellar Na⁺ /K⁺ -ATPase.. Traffic (Copenhagen, Denmark). DOI: 10.1111/tra.12332. Cao, Y., Sarria, I., Fehlhaber, K. E., Kamasawa, N., Orlandi, C., James, K. N., Hazen, J. L., Gardner, M. R., Farzan, M., Lee, A., Baker, S., Baldwin, K., Sampath, A. P. & Martemyanov, K. A. (2015). Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision.. Neuron, 87(6), 1248-60. DOI: 10.1016/j.neuron.2015.09.002. Pan, Y., Laird, J. G., Yamaguchi, D. M. & Baker, S. A. (2015). An N-Terminal ER Export Signal Facilitates the Plasma Membrane Targeting of HCN1 Channels in Photoreceptors.. Investigative ophthalmology & visual science, 56(6), 3514-21. DOI: 10.1167/iovs.15-16902. Pan, Y., Bhattarai, S., Modesto, M., Drack, A. V., Chetkovich, D. M. & Baker, S. A. (2014). TRIP8b is required for maximal expression of HCN1 in the mouse retina. PLoS One, 9(1), e850850. Pan, Y., Laird, J. G., Yamaguchi, D. M. & Baker, S. A. (2014). A di-arginine ER retention signal regulates trafficking of HCN1 channels from the early secretory pathway to the plasma membrane. Cellular and Molecular Life Sciences. DOI: 10.1007/s00018-014-1705-1. Pearring, J. N., Lieu, E. C., Winter, J. R., Baker, S. A. & Arshavsky, V. Y. (2014). R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain.. Mol Biol Cell, 25(17), 2644-9. DOI: 10.1091/mbc.E14-02-0747. Salinas, R. Y., Baker, S. A., Gospe, S. M. & Arshavsky, V. Y. (2013). A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segments. PloS one, 8(1), e54292. Baker, S. A., Kerov, V. (2013). Photoreceptor inner and outer segments. pp. 231-65. Curr Top Membr. Knoflach, D., Kerov, V., Satori, G. B., Obermair, G. J., Schmuckermair, C., Liu, X., Sothilingam, V., Garrido, M. G., Baker, S. A., Glosmann, M., Schicker, K., Seeliger, M., Lee, A. & Koschak, A. (2013). Cav1.4 IT mouse as model for vision impairment in human congenital stationary night blindness type 2. Channels (Austin), 7(6).