研究领域

Our lab works at the interface of engineering, surface science, and biology to develop novel drug delivery systems for the targeted delivery of therapeutics in the lungs. We explore the complex physicochemical interactions between these therapeutic delivery systems and the various cells and fluids native to the lungs. We are also investigating the formation of exhaled bioaerosols in the lungs and new ways to suppress the transmission of airborne pathogens that are carried in these bioaerosols. Our collaborations span the UI campus, with ongoing projects with researchers in Pharmacy, Engineering, Medicine, Public Health and Chemistry.

Novel pulmonary drug delivery systemstargeted therapies to treat infectious diseasesaerosol biointeractions in environmental exposures and drug delivery

近期论文

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A. Farnoud, J. Fiegel. Calf lung surfactant recovers surface functionality after exposure to aerosols containing polymeric particles. J. Aerosol Med. In Press. S. Sommerfeld Ross, M.L. Falsetta Wood, M.A. Apicella, J.M. Reinhardt, J. Fiegel. Quantification of confocal images of biofilms grown on irregular surfaces. J. Microbiol. Methods. 2014; 100: 111-120. A. Farnoud, J. Fiegel. Interaction of dipalmitoyl phosphatidylcholine monolayers with a particle-laden subphase. J. Phys. Chem. B. 2013; 117(40): 12124-12134. E.D. Oldham, S. Seelam, C.F. Lema, R.J. Aguilera, J. Fiegel, S.E. Rankin, B.L. Knutson, H.-J. Lehmler. Synthesis, surface properties and biocompatibility of 1,2,3-triazoles containing alkyl beta-D-xylopyranoside surfactants. Carbohydrate Chemistry. 2013; 379: 68-77. R. Hamed, J. Fiegel. Synthetic Tracheal Mucus with Native Rheological and Surface Tension Properties. J. Biomed. Mater. Res. Part A. 2014; 102(6): 1788-1798. A. Farnoud, J. Fiegel. Low concentrations of negatively charged sub-micron particles alter the microstructure of DPPC at the air-water interface. Colloid. Surface. A. 2012. 415(5): 320-327. S. Sommerfeld Ross, J. Fiegel. Nutrient dispersion enhances conventional antibiotic activity against Pseudomonas aeruginosa biofilms. Int. J. Antimicrob. Agents 2012. 40: 177-181. S. Sommerfeld Ross, J.M. Reinhardt, J. Fiegel. Enhanced analysis of bacteria susceptibility in connected biofilms. J. Microbiol. Methods 2012. 90(1): 9-14. E.D. Oldham, W. Xie, A.M. Farnoud, J. Fiegel, H.-J. Lehmler. Disruption of phosphatidylcholine monolayers and bilayers by perfluorobutanesulfonate. J. Phys. Chem. B 2012. 116: 9999-10007. J.S. Patton, J.D. Brain, L.A. Davies, J. Fiegel, M. Gumbleton, K.-J. Kim, M. Sakagami, R. Vanbever, C. Ehrhardt. The particle has landed - Characterizing the fate of inhaled pharmaceuticals. J. Aerosol Med. Pulm. Drug Deliv. 2010. 23(S2): S71-S87.